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1OKY
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STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH STAUROSPORINE
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1, GLYCEROL, SULFATE ION, ...
Authors:Komander, D., Kular, G.S., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2003-08-01
Release date:2004-07-29
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for Ucn-01 (7-Hydroxystaurosporine) Specificity and Pdk1 (3-Phosphoinositide-Dependent Protein Kinase-1) Inhibition
Biochem.J., 375, 2003
1OKZ
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STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH UCN-01
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1, GLYCEROL, SULFATE ION, ...
Authors:Komander, D., Kular, G.S., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2003-08-01
Release date:2004-07-29
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structural Basis for Ucn-01 (7-Hydroxystaurosporine) Specificity and Pdk1 (3-Phosphoinositide-Dependent Protein Kinase-1) Inhibition
Biochem.J., 375, 2003
1UU3
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STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH LY333531
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, SULFATE ION, ...
Authors:Komander, D., Kular, G.S., Schuttelkopf, A.W., Deak, M., Prakash, K.R., Bain, J., Elliot, M., Garrido-Franco, M., Kozikowski, A.P., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2003-12-15
Release date:2004-03-04
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004
1UU7
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STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-2
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, 3-(1H-INDOL-3-YL)-4-(1-{2-[(2S)-1-METHYLPYRROLIDINYL]ETHYL}-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, ...
Authors:Komander, D., Kular, G.S., Schuttelkopf, A.W., Deak, M., Prakash, K.R., Bain, J., Elliot, M., Garrido-Franco, M., Kozikowski, A.P., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2003-12-16
Release date:2004-03-04
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004
1UU8
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STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-1
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, SULFATE ION, ...
Authors:Komander, D., Kular, G.S., Schuttelkopf, A.W., Deak, M., Prakash, K.R., Bain, J., Elliot, M., Garrido-Franco, M., Kozikowski, A.P., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2003-12-16
Release date:2004-03-04
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004
1UU9
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STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-3
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, SULFATE ION, ...
Authors:Komander, D., Kular, G.S., Schuttelkopf, A.W., Deak, M., Prakash, K.R., Bain, J., Elliot, M., Garrido-Franco, M., Kozikowski, A.P., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2003-12-16
Release date:2004-03-04
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004
1UVR
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STRUCTURE OF HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH BIM-8
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, SULFATE ION, ...
Authors:Komander, D., Garrido-Franco, M., Kular, G.S., Schuttelkopf, A.W., Deak, M., Prakash, K.R., Bain, J., Elliot, M., Kozikowski, A.P., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2004-01-22
Release date:2004-03-04
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004
2BIY
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STRUCTURE OF PDK1-S241A MUTANT KINASE DOMAIN
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, SULFATE ION, ...
Authors:Komander, D., Kular, G.S., Deak, M., Alessi, D.R., van Aalten, D.M.F.
Deposit date:2005-01-26
Release date:2005-02-23
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding.
J. Biol. Chem., 280, 2005
1W1D
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CRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAIN BOUND TO INOSITOL (1,3,4,5)-TETRAKISPHOSPHATE
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, GOLD ION, ...
Authors:Komander, D., Deak, M., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2004-06-21
Release date:2004-11-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural Insights Into the Regulation of Pdk1 by Phosphoinositides and Inositol Phosphates
Embo J., 23, 2004
1W1G
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CRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAIN BOUND TO DIC4-PHOSPHATIDYLINOSITOL (3,4,5)-TRISPHOSPHATE
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, (2R)-3-{[(S)-{[(2S,3R,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-(1-HYDROXYBUTOXY)PROPYL BUTYRATE
Authors:Komander, D., Deak, M., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2004-06-21
Release date:2004-11-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural Insights Into the Regulation of Pdk1 by Phosphoinositides and Inositol Phosphates
Embo J., 23, 2004
1W1H
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CRYSTAL STRUCTURE OF THE PDK1 PLECKSTRIN HOMOLOGY (PH) DOMAIN
Descriptor:3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, GLYCEROL, SULFATE ION
Authors:Komander, D., Deak, M., Alessi, D.R., Van Aalten, D.M.F.
Deposit date:2004-06-21
Release date:2004-11-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural Insights Into the Regulation of Pdk1 by Phosphoinositides and Inositol Phosphates
Embo J., 23, 2004