Author results

1ECB
  • Download 1ecb
  • View 1ecb
Molmil generated image of 1ecb
ESCHERICHIA COLI GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE (PRPP) AMIDOTRANSFERASE COMPLEXED WITH 2 GMP, 1 MG PER SUBUNIT
Descriptor:GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE, MAGNESIUM ION, GUANOSINE-5'-MONOPHOSPHATE
Authors:Krahn, J.M., Smith, J.L.
Deposit date:1997-07-15
Release date:1998-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Coupled formation of an amidotransferase interdomain ammonia channel and a phosphoribosyltransferase active site.
Biochemistry, 36, 1997
1ECC
  • Download 1ecc
  • View 1ecc
Molmil generated image of 1ecc
ESCHERICHIA COLI GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE (PRPP) AMIDOTRANSFERASE COMPLEXED WITH MN-CPRPP AND 5-OXO-NORLEUCINE
Descriptor:GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE, MANGANESE (II) ION, 5-OXO-L-NORLEUCINE, ...
Authors:Krahn, J.M., Smith, J.L.
Deposit date:1997-07-09
Release date:1998-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Coupled formation of an amidotransferase interdomain ammonia channel and a phosphoribosyltransferase active site.
Biochemistry, 36, 1997
1MQ2
  • Download 1mq2
  • View 1mq2
Molmil generated image of 1mq2
HUMAN DNA POLYMERASE BETA COMPLEXED WITH GAPPED DNA CONTAINING AN 8-OXO-7,8-DIHYDRO-GUANINE AND DAMP
Descriptor:5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(2DA))-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Krahn, J.M., Beard, W.A., Miller, H., Grollman, A.P., Wilson, S.H.
Deposit date:2002-09-13
Release date:2003-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of DNA Polymerase beta with the Mutagenic DNA Lesion 8-oxodeoxyguanine Reveals Structural Insights into its Coding Potential
Structure, 11, 2003
1MQ3
  • Download 1mq3
  • View 1mq3
Molmil generated image of 1mq3
HUMAN DNA POLYMERASE BETA COMPLEXED WITH GAPPED DNA CONTAINING AN 8-OXO-7,8-DIHYDRO-GUANINE TEMPLATE PAIRED WITH DCTP
Descriptor:5'-D(*CP*CP*GP*AP*CP*(8OG)P*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Krahn, J.M., Beard, W.A., Miller, H., Grollman, A.P., Wilson, S.H.
Deposit date:2002-09-13
Release date:2003-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of DNA Polymerase beta with the Mutagenic DNA Lesion 8-oxodeoxyguanine Reveals Structural Insights into its Coding Potential
Structure, 11, 2003
1TV9
  • Download 1tv9
  • View 1tv9
Molmil generated image of 1tv9
HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA CONTAINING A MISMATCHED TEMPLATE ADENINE AND INCOMING CYTIDINE
Descriptor:5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Krahn, J.M., Beard, W.M., Wilson, S.H.
Deposit date:2004-06-29
Release date:2004-11-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:STRUCTURAL INSIGHTS INTO DNA POLYMERASE BETA DETERRENTS FOR MISINCORPORATION SUPPORT OF AN INDUCED-FIT MECHANISM FOR FIDELITY
Structure, 12, 2004
1TVA
  • Download 1tva
  • View 1tva
Molmil generated image of 1tva
HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA CONTAINING A MISMATCHED TEMPLATE THYMIDINE AND INCOMING CYTIDINE
Descriptor:5'-D(*CP*CP*GP*AP*CP*TP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ...
Authors:Krahn, J.M., Beard, W.A., Wilson, S.H.
Deposit date:2004-06-29
Release date:2004-11-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural insights into DNA polymerase Beta deterrents for misincorporation support an induced-fit mechanism for fidelity
Structure, 12, 2004
2RH2
  • Download 2rh2
  • View 2rh2
Molmil generated image of 2rh2
HIGH RESOLUTION DHFR R-67
Descriptor:Dihydrofolate reductase type 2, (4R)-2-METHYLPENTANE-2,4-DIOL
Authors:Krahn, J.M., London, R.E.
Deposit date:2007-10-05
Release date:2008-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (0.96 Å)
Cite:Crystal Structure of a Type II Dihydrofolate Reductase Catalytic Ternary Complex
Biochemistry, 46, 2007
2RK1
  • Download 2rk1
  • View 2rk1
Molmil generated image of 2rk1
DHFR R67 COMPLEXED WITH NADP AND DIHYDROFOLATE
Descriptor:Dihydrofolate reductase type 2, DIHYDROFOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Krahn, J.M., London, R.E.
Deposit date:2007-10-16
Release date:2008-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Crystal structure of a type II dihydrofolate reductase catalytic ternary complex.
Biochemistry, 46, 2007
2RK2
  • Download 2rk2
  • View 2rk2
Molmil generated image of 2rk2
DHFR R-67 COMPLEXED WITH NADP
Descriptor:Dihydrofolate reductase type 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (4R)-2-METHYLPENTANE-2,4-DIOL
Authors:Krahn, J.M., London, R.E.
Deposit date:2007-10-16
Release date:2008-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of a type II dihydrofolate reductase catalytic ternary complex.
Biochemistry, 46, 2007
1ECF
  • Download 1ecf
  • View 1ecf
Molmil generated image of 1ecf
ESCHERICHIA COLI GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE (PRPP) AMIDOTRANSFERASE
Descriptor:GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE, PIPERAZINE-N,N'-BIS(2-ETHANESULFONIC ACID)
Authors:Krahn, J.M.
Deposit date:1996-04-23
Release date:1996-11-08
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of glutamine phosphoribosylpyrophosphate amidotransferase from Escherichia coli.
Protein Sci., 7, 1998
1ECG
  • Download 1ecg
  • View 1ecg
Molmil generated image of 1ecg
DON INACTIVATED ESCHERICHIA COLI GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE (PRPP) AMIDOTRANSFERASE
Descriptor:GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE, 5-OXO-L-NORLEUCINE, PIPERAZINE-N,N'-BIS(2-ETHANESULFONIC ACID)
Authors:Krahn, J.M.
Deposit date:1996-04-23
Release date:1996-11-08
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and function of the glutamine phosphoribosylpyrophosphate amidotransferase glutamine site and communication with the phosphoribosylpyrophosphate site.
J.Biol.Chem., 271, 1996
1XSL
  • Download 1xsl
  • View 1xsl
Molmil generated image of 1xsl
CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE LAMBDA IN COMPLEX WITH A ONE NUCLEOTIDE DNA GAP
Descriptor:5'-D(*CP*GP*GP*CP*AP*GP*CP*GP*CP*AP*C)-3', 5'-D(*GP*TP*GP*CP*GP*C)-3', 5'-D(P*GP*CP*CP*G)-3', ...
Authors:Garcia-Diaz, M., Bebenek, K., Krahn, J.M., Kunkel, T.A., Pedersen, L.C.
Deposit date:2004-10-19
Release date:2005-01-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A closed conformation for the Pol lambda catalytic cycle.
Nat.Struct.Mol.Biol., 12, 2005
1XSN
  • Download 1xsn
  • View 1xsn
Molmil generated image of 1xsn
CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE LAMBDA IN COMPLEX WITH A ONE NUCLEOTIDE DNA GAP AND DDTTP
Descriptor:5'-D(*CP*GP*GP*CP*AP*AP*TP*AP*CP*TP*G)-3', 5'-D(*CP*AP*GP*TP*AP*(2DT))-3', 5'-D(P*GP*CP*CP*G)-3', ...
Authors:Garcia-Diaz, M., Bebenek, K., Krahn, J.M., Kunkel, T.A., Pedersen, L.C.
Deposit date:2004-10-19
Release date:2005-01-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A closed conformation for the Pol lambda catalytic cycle.
Nat.Struct.Mol.Biol., 12, 2005
1XSP
  • Download 1xsp
  • View 1xsp
Molmil generated image of 1xsp
CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE LAMBDA IN COMPLEX WITH NICKED DNA AND PYROPHOSPHATE
Descriptor:5'-D(*CP*GP*GP*CP*CP*GP*TP*AP*CP*TP*G)-3', 5'-D(*CP*AP*GP*TP*AP*CP*G)-3', 5'-D(P*GP*CP*CP*G)-3', ...
Authors:Garcia-Diaz, M., Bebenek, K., Krahn, J.M., Kunkel, T.A., Pedersen, L.C.
Deposit date:2004-10-19
Release date:2005-01-18
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A closed conformation for the Pol lambda catalytic cycle.
Nat.Struct.Mol.Biol., 12, 2005
3HW8
  • Download 3hw8
  • View 3hw8
Molmil generated image of 3hw8
TERNARY COMPLEX OF DNA POLYMERASE LAMBDA OF A TWO NUCLEOTIDE GAPPED DNA SUBSTRATE WITH A C IN THE SCRUNCH SITE
Descriptor:DNA polymerase lambda, 5'-D(*CP*GP*GP*CP*CP*AP*AP*TP*AP*CP*TP*G)-3', 5'-D(*CP*AP*GP*TP*AP*T)-3', ...
Authors:Garcia-Diaz, M., Bebenek, K., Larrea, A.A., Havener, J.M., Perera, L., Krahn, J.M., Pedersen, L.C., Ramsden, D.A., Kunkel, T.A.
Deposit date:2009-06-17
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Scrunching Durning DNA Repair Synthesis
To be Published
3HX0
  • Download 3hx0
  • View 3hx0
Molmil generated image of 3hx0
TERNARY COMPLEX OF L277A, H511A, R514 MUTANT POL LAMBDA BOUND TO A 2 NUCLEOTIDE GAPPED DNA SUBSTRATE WITH A SCRUNCHED DA
Descriptor:DNA polymerase lambda, 5'-D(*CP*GP*GP*CP*AP*AP*AP*TP*AP*CP*TP*G)-3', 5'-D(*CP*AP*GP*TP*AP*T)-3', ...
Authors:Garcia-Diaz, M., Bebenek, K., Larrea, A.A., Havener, J.M., Perera, L., Krahn, J.M., Pedersen, L.C., Ramsden, D.A., Kunkel, T.A.
Deposit date:2009-06-19
Release date:2009-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Scrunching During DNA Repair Synthesis
To be Published
4DD8
  • Download 4dd8
  • View 4dd8
Molmil generated image of 4dd8
ADAM-8 METALLOPROTEINASE DOMAIN WITH BOUND BATIMASTAT
Descriptor:Disintegrin and metalloproteinase domain-containing protein 8, 4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE, CALCIUM ION, ...
Authors:Hall, T., Shieh, H.S., Day, J.E., Caspers, N., Chrencik, J.E., Williams, J.M., Pegg, L.E., Pauley, A.M., Moon, A.F., Krahn, J.M., Fischer, D.H., Kiefer, J.R., Tomasselli, A.G., Zack, M.D.
Deposit date:2012-01-18
Release date:2012-06-06
Last modified:2012-06-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of human ADAM-8 catalytic domain complexed with batimastat.
Acta Crystallogr.,Sect.F, 68, 2012
1ECJ
  • Download 1ecj
  • View 1ecj
Molmil generated image of 1ecj
ESCHERICHIA COLI GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE (PRPP) AMIDOTRANSFERASE COMPLEXED WITH 2 AMP PER TETRAMER
Descriptor:GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE, ADENOSINE MONOPHOSPHATE
Authors:Muchmore, C.R., Krahn, J.M., Smith, J.L.
Deposit date:1997-07-16
Release date:1998-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of glutamine phosphoribosylpyrophosphate amidotransferase from Escherichia coli.
Protein Sci., 7, 1998
1OMX
  • Download 1omx
  • View 1omx
Molmil generated image of 1omx
CRYSTAL STRUCTURE OF MOUSE ALPHA-1,4-N-ACETYLHEXOSAMINYLTRANSFERASE (EXTL2)
Descriptor:Alpha-1,4-N-acetylhexosaminyltransferase EXTL2, 1,2-ETHANEDIOL
Authors:Pedersen, L.C., Dong, J., Taniguchi, F., Kitagawa, H., Krahn, J.M., Pedersen, L.G., Sugahara, K., Negishi, M.
Deposit date:2003-02-26
Release date:2003-04-22
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of an alpha-1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis
J.Biol.Chem., 278, 2003
1OMZ
  • Download 1omz
  • View 1omz
Molmil generated image of 1omz
CRYSTAL STRUCTURE OF MOUSE ALPHA-1,4-N-ACETYLHEXOSAMINYLTRANSFERASE (EXTL2) IN COMPLEX WITH UDPGALNAC
Descriptor:Alpha-1,4-N-acetylhexosaminyltransferase EXTL2, MANGANESE (II) ION, URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE, ...
Authors:Pedersen, L.C., Dong, J., Taniguchi, F., Kitagawa, H., Krahn, J.M., Pedersen, L.G., Sugahara, K., Negishi, M.
Deposit date:2003-02-26
Release date:2003-04-22
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of an alpha-1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis
J.Biol.Chem., 278, 2003
1ON6
  • Download 1on6
  • View 1on6
Molmil generated image of 1on6
CRYSTAL STRUCTURE OF MOUSE ALPHA-1,4-N-ACETYLHEXOSAMINOTRANSFERASE (EXTL2) IN COMPLEX WITH UDPGLCNAC
Descriptor:Alpha-1,4-N-acetylhexosaminyltransferase EXTL2, MANGANESE (II) ION, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, ...
Authors:Pedersen, L.C., Dong, J., Taniguchi, F., Kitagawa, H., Krahn, J.M., Pedersen, L.G., Sugahara, K., Negishi, M.
Deposit date:2003-02-27
Release date:2003-04-22
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of an alpha-1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis
J.Biol.Chem., 278, 2003
1ON8
  • Download 1on8
  • View 1on8
Molmil generated image of 1on8
CRYSTAL STRUCTURE OF MOUSE ALPHA-1,4-N-ACETYLHEXOSAMINYLTRANSFERASE (EXTL2) WITH UDP AND GLCUAB(1-3)GALB(1-O)-NAPHTHALENELMETHANOL AN ACCEPTOR SUBSTRATE ANALOG
Descriptor:Alpha-1,4-N-acetylhexosaminyltransferase EXTL2, BETA-D-GLUCOPYRANURONIC ACID, BETA-D-GALACTOSE, ...
Authors:Pedersen, L.C., Dong, J., Taniguchi, F., Kitagawa, H., Krahn, J.M., Pedersen, L.G., Sugahara, K., Negishi, M.
Deposit date:2003-02-27
Release date:2003-04-22
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of an alpha-1,4-N-acetylhexosaminyltransferase (EXTL2), a member of the exostosin gene family involved in heparan sulfate biosynthesis
J.Biol.Chem., 278, 2003
1RZT
  • Download 1rzt
  • View 1rzt
Molmil generated image of 1rzt
CRYSTAL STRUCTURE OF DNA POLYMERASE LAMBDA COMPLEXED WITH A TWO NUCLEOTIDE GAP DNA MOLECULE
Descriptor:5'-D(*CP*GP*GP*CP*AP*AP*CP*GP*CP*AP*C)-3', 5'-D(*GP*TP*GP*CP*G)-3', 5'-D(P*GP*CP*CP*G)-3', ...
Authors:Pedersen, L.C., Garcia-Diaz, M., Bebenek, K., Krahn, J.M., Blanco, L., Kunkel, T.A.
Deposit date:2003-12-29
Release date:2004-03-02
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A structural solution for the DNA polymerase lambda-dependent repair of DNA gaps with minimal homology.
Mol.Cell, 13, 2004
1S5S
  • Download 1s5s
  • View 1s5s
Molmil generated image of 1s5s
PORCINE TRYPSIN COMPLEXED WITH GUANIDINE-3-PROPANOL INHIBITOR
Descriptor:Trypsin, CALCIUM ION, GUANIDINE-3-PROPANOL, ...
Authors:Transue, T.R., Krahn, J.M., Gabel, S.A., DeRose, E.F., London, R.E.
Deposit date:2004-01-21
Release date:2004-03-16
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:X-ray and NMR characterization of covalent complexes of trypsin, borate, and alcohols.
Biochemistry, 43, 2004
1S6F
  • Download 1s6f
  • View 1s6f
Molmil generated image of 1s6f
PORCINE TRYPSIN COVALENT COMPLEX WITH BORATE AND GUANIDINE-3 INHIBITOR
Descriptor:Trypsin, CALCIUM ION, SULFATE ION, ...
Authors:Transue, T.R., Krahn, J.M., Gabel, S.A., Derose, E.F., London, R.E.
Deposit date:2004-01-23
Release date:2004-03-16
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-ray and NMR characterization of covalent complexes of trypsin, borate, and alcohols.
Biochemistry, 43, 2004