2RK1
DHFR R67 Complexed with NADP and dihydrofolate
Summary for 2RK1
| Entry DOI | 10.2210/pdb2rk1/pdb |
| Related | 2P4T 2RH2 |
| Descriptor | Dihydrofolate reductase type 2, DIHYDROFOLIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
| Functional Keywords | oxidoreductase, nadp, dihydrofolate, asymmetric ligand binding, antibiotic resistance, methotrexate resistance, one-carbon metabolism, plasmid, trimethoprim resistance |
| Biological source | Escherichia coli |
| Total number of polymer chains | 1 |
| Total formula weight | 8273.87 |
| Authors | Krahn, J.M.,London, R.E. (deposition date: 2007-10-16, release date: 2008-06-03, Last modification date: 2023-08-30) |
| Primary citation | Krahn, J.M.,Jackson, M.R.,DeRose, E.F.,Howell, E.E.,London, R.E. Crystal structure of a type II dihydrofolate reductase catalytic ternary complex. Biochemistry, 46:14878-14888, 2007 Cited by PubMed: 18052202DOI: 10.1021/bi701532r PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.26 Å) |
Structure validation
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