Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE DHF A 0 |
| Chain | Residue |
| A | GLN67 |
| A | HOH605 |
| A | HOH608 |
| A | ILE68 |
| A | TYR69 |
| A | HOH547 |
| A | HOH550 |
| A | HOH575 |
| A | HOH581 |
| A | HOH596 |
| A | HOH603 |
| site_id | AC2 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE NAP A 1 |
| Chain | Residue |
| A | LYS32 |
| A | SER34 |
| A | GLY35 |
| A | ALA36 |
| A | LEU50 |
| A | GLY64 |
| A | SER65 |
| A | GLN67 |
| A | ILE68 |
| A | TYR69 |
| A | PRO70 |
| A | ALA72 |
| A | ALA73 |
| A | HOH503 |
| A | HOH504 |
| A | HOH506 |
| A | HOH508 |
| A | HOH509 |
| A | HOH510 |
| A | HOH527 |
| A | HOH538 |
| A | HOH547 |
| A | HOH550 |
| A | HOH565 |
| A | HOH567 |
| A | HOH575 |
| A | HOH578 |
| A | HOH581 |
| A | HOH590 |
| A | HOH591 |
| A | HOH592 |
| A | HOH596 |
| A | HOH597 |
| A | HOH605 |
| A | HOH608 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE MRD A 500 |
| Chain | Residue |
| A | ALA22 |
| A | GLY25 |
| A | ARG76 |
| A | ILE77 |
| A | ASN78 |
| A | HOH559 |
| A | HOH580 |
| A | HOH595 |
| A | HOH600 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MRD A 501 |
| Chain | Residue |
| A | GLY35 |
| A | ASN49 |
| A | LEU50 |
| A | PRO52 |
| A | HOH570 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MRD A 502 |
| Chain | Residue |
| A | PHE24 |
| A | GLY25 |
| A | TRP45 |
| A | HOH600 |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | LYS32 | |
| A | VAL66 | |
| Chain | Residue | Details |
| A | ILE68 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1vie |
| Chain | Residue | Details |
| A | ILE68 | |
| A | LYS32 | |
| A | TYR69 | |
| A | GLN67 | |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 752 |
| Chain | Residue | Details |
| A | LYS32 | electrostatic stabiliser |
| A | GLN67 | electrostatic stabiliser |
| A | ILE68 | electrostatic stabiliser |
| A | TYR69 | electrostatic stabiliser |
