6VCJ

Crystal structure of hsDHFR in complex with NADP+, DAP, and R-naproxen

Summary for 6VCJ

Entry DOI	10.2210/pdb6vcj/pdb
Descriptor	Dihydrofolate reductase, PYRIMIDINE-2,4-DIAMINE, (2R)-2-(6-methoxynaphthalen-2-yl)propanoic acid, ... (6 entities in total)
Functional Keywords	nadp+, 2, 4-diaminopyridine, r-naproxen, inhibitor, complex, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	92251.81
Authors	Pedersen, L.C.,London, R.E.,Gabel, S.A.,Krahn, J.M.,DeRose, E.F. (deposition date: 2019-12-21, release date: 2020-10-28, Last modification date: 2023-10-11)
Primary citation	Duff Jr., M.R.,Gabel, S.A.,Pedersen, L.C.,DeRose, E.F.,Krahn, J.M.,Howell, E.E.,London, R.E. The Structural Basis for Nonsteroidal Anti-Inflammatory Drug Inhibition of Human Dihydrofolate Reductase. J.Med.Chem., 63:8314-8324, 2020 Cited by PubMed: 32658475 DOI: 10.1021/acs.jmedchem.0c00546 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.34 Å)

Structure validation