6VCJ
Crystal structure of hsDHFR in complex with NADP+, DAP, and R-naproxen
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Dihydrofolate reductase | polymer | 188 | 21537.8 | 4 | UniProt (P00374) Pfam (PF00186) | Homo sapiens (Human) | |
| 2 | E, I, M, Q (A, B, C, D) | PYRIMIDINE-2,4-DIAMINE | non-polymer | 110.1 | 4 | Chemie (LG3) PubChem (67431) | |||
| 3 | F, J, N, R (A, B, C, D) | (2R)-2-(6-methoxynaphthalen-2-yl)propanoic acid | non-polymer | 230.3 | 4 | Chemie (NPX) PubChem (1302) PubChem (156391) PubChem (169118) | |||
| 4 | G, K, O, S (A, B, C, D) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) PubChem (5885) PubChem (46936685) PubChem (71717786) PubChem (4412) PubChem (90473931) PubChem (91972139) PubChem (145946263) PubChem (153311489) PubChem (174001641) PubChem (165382010) | |||
| 5 | H, L, P, T (A, B, C, D) | FOLIC ACID | non-polymer | 441.4 | 4 | Chemie (FOL) | |||
| 6 | U, V, W, X (A, B, C, D) | water | water | 18.0 | 76 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 0 - 186 (UniProt: P00374)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 86151.1 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 6100.7 | |
| All* | Total formula weight | 92251.8 |
