2RK2
DHFR R-67 complexed with NADP
Summary for 2RK2
Entry DOI | 10.2210/pdb2rk2/pdb |
Related | 2P4T 2RH2 |
Descriptor | Dihydrofolate reductase type 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (4R)-2-METHYLPENTANE-2,4-DIOL, ... (4 entities in total) |
Functional Keywords | oxidoreductase, nadp, asymmetric ligand binding, antibiotic resistance, methotrexate resistance, one-carbon metabolism, trimethoprim resistance |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 7830.45 |
Authors | Krahn, J.M.,London, R.E. (deposition date: 2007-10-16, release date: 2008-06-03, Last modification date: 2023-08-30) |
Primary citation | Krahn, J.M.,Jackson, M.R.,DeRose, E.F.,Howell, E.E.,London, R.E. Crystal structure of a type II dihydrofolate reductase catalytic ternary complex. Biochemistry, 46:14878-14888, 2007 Cited by PubMed: 18052202DOI: 10.1021/bi701532r PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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