2RK2
DHFR R-67 complexed with NADP
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE NAP A 1 |
| Chain | Residue |
| A | LYS32 |
| A | TYR69 |
| A | PRO70 |
| A | ALA72 |
| A | ALA73 |
| A | HOH503 |
| A | HOH504 |
| A | HOH506 |
| A | HOH507 |
| A | HOH508 |
| A | HOH509 |
| A | SER34 |
| A | HOH534 |
| A | HOH543 |
| A | HOH546 |
| A | HOH558 |
| A | HOH560 |
| A | HOH565 |
| A | HOH567 |
| A | HOH568 |
| A | HOH576 |
| A | HOH577 |
| A | GLY35 |
| A | HOH579 |
| A | HOH582 |
| A | HOH583 |
| A | HOH586 |
| A | ALA36 |
| A | LEU50 |
| A | GLY64 |
| A | SER65 |
| A | GLN67 |
| A | ILE68 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MRD A 500 |
| Chain | Residue |
| A | ALA22 |
| A | GLY25 |
| A | ILE77 |
| A | ASN78 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MRD A 501 |
| Chain | Residue |
| A | GLY35 |
| A | LEU50 |
| A | HOH574 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MRD A 502 |
| Chain | Residue |
| A | PHE24 |
| A | GLY25 |
| A | TRP45 |
| A | HOH559 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17473013","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18052202","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2P4T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2RK1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2RK2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18052202","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2RK1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1vie |
| Chain | Residue | Details |
| A | ILE68 | |
| A | LYS32 | |
| A | TYR69 | |
| A | GLN67 |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 752 |
| Chain | Residue | Details |
| A | LYS32 | electrostatic stabiliser |
| A | GLN67 | electrostatic stabiliser |
| A | ILE68 | electrostatic stabiliser |
| A | TYR69 | electrostatic stabiliser |
