2RK2

DHFR R-67 complexed with NADP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004146	molecular_function	dihydrofolate reductase activity
A	0009410	biological_process	response to xenobiotic stimulus

Functional Information from PDB Data

site_id	AC1
Number of Residues	33
Details	BINDING SITE FOR RESIDUE NAP A 1

Chain	Residue
A	LYS32
A	TYR69
A	PRO70
A	ALA72
A	ALA73
A	HOH503
A	HOH504
A	HOH506
A	HOH507
A	HOH508
A	HOH509
A	SER34
A	HOH534
A	HOH543
A	HOH546
A	HOH558
A	HOH560
A	HOH565
A	HOH567
A	HOH568
A	HOH576
A	HOH577
A	GLY35
A	HOH579
A	HOH582
A	HOH583
A	HOH586
A	ALA36
A	LEU50
A	GLY64
A	SER65
A	GLN67
A	ILE68

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MRD A 500

Chain	Residue
A	ALA22
A	GLY25
A	ILE77
A	ASN78

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MRD A 501

Chain	Residue
A	GLY35
A	LEU50
A	HOH574

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MRD A 502

Chain	Residue
A	PHE24
A	GLY25
A	TRP45
A	HOH559

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:17473013, ECO:0000269|PubMed:18052202, ECO:0007744|PDB:2P4T, ECO:0007744|PDB:2RK1, ECO:0007744|PDB:2RK2

Chain	Residue	Details
A	LYS32
A	VAL66

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:18052202, ECO:0007744|PDB:2RK1

Chain	Residue	Details
A	ILE68

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1vie

Chain	Residue	Details
A	ILE68
A	LYS32
A	TYR69
A	GLN67

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site_id	MCSA1
Number of Residues	4
Details	M-CSA 752

Chain	Residue	Details
A	LYS32	electrostatic stabiliser
A	GLN67	electrostatic stabiliser
A	ILE68	electrostatic stabiliser
A	TYR69	electrostatic stabiliser

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