3SZQ
 
 | | Structure of an S. pombe APTX/DNA/AMP/Zn complex | | Descriptor: | 5'-D(*CP*CP*CP*TP*G)-3', 5'-D(*TP*AP*TP*CP*GP*GP*AP*AP*TP*CP*AP*GP*GP*G)-3', ADENOSINE MONOPHOSPHATE, ... | | Authors: | Tumbale, P, Krahn, J, Williams, R.S. | | Deposit date: | 2011-07-19 | | Release date: | 2011-10-12 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2.353 Å) | | Cite: | Structure of an aprataxin-DNA complex with insights into AOA1 neurodegenerative disease.
Nat.Struct.Mol.Biol., 18, 2011
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7N3Y
 | | Crystal Structure of Saccharomyces cerevisiae Apn2 Catalytic Domain E59Q/D222N Mutant in Complex with DNA | | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, CITRIC ACID, ... | | Authors: | Wojtaszek, J.L, Krahn, J, Wallace, B.D, Williams, R.S. | | Deposit date: | 2021-06-02 | | Release date: | 2022-09-28 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.73 Å) | | Cite: | Molecular basis for processing of topoisomerase 1-triggered DNA damage by Apn2/APE2.
Cell Rep, 41, 2022
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4J5S
 | | TARG1 (C6orf130), Terminal ADP-ribose Glycohydrolase 1 ADP-ribose complex | | Descriptor: | 1,2-ETHANEDIOL, 1,3,2-DIOXABOROLAN-2-OL, BORATE ION, ... | | Authors: | Schellenberg, M.J, Appel, C.D, Krahn, J, Williams, R.S. | | Deposit date: | 2013-02-09 | | Release date: | 2013-03-27 | | Last modified: | 2013-07-03 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease.
Embo J., 32, 2013
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4J5Q
 | | TARG1 (C6orf130), Terminal ADP-ribose Glycohydrolase 1, apo structure | | Descriptor: | O-acetyl-ADP-ribose deacetylase 1 | | Authors: | Schellenberg, M.J, Appel, C.D, Krahn, J, Williams, R.S. | | Deposit date: | 2013-02-09 | | Release date: | 2013-03-27 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease.
Embo J., 32, 2013
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4J5R
 | | TARG1 (C6orf130), Terminal ADP-ribose Glycohydrolase 1 bound to ADP-HPD | | Descriptor: | 1,2-ETHANEDIOL, 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, CHLORIDE ION, ... | | Authors: | Schellenberg, M.J, Appel, C.D, Krahn, J, Williams, R.S. | | Deposit date: | 2013-02-09 | | Release date: | 2013-03-27 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease.
Embo J., 32, 2013
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1O57
 | | CRYSTAL STRUCTURE OF THE PURINE OPERON REPRESSOR OF BACILLUS SUBTILIS | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HEXAETHYLENE GLYCOL, NONAETHYLENE GLYCOL, ... | | Authors: | Sinha, S.C, Krahn, J, Shin, B.S, Tomchick, D.R, Zalkin, H, Smith, J.L. | | Deposit date: | 2003-04-20 | | Release date: | 2003-08-26 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The Purine Repressor of Bacillus Subtilis: A Novel Combination of Domains Adapted for Transcription Regulation
J.Bacteriol., 185, 2003
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6CVT
 | | Human Aprataxin (Aptx) V263G bound to RNA-DNA, AMP and Zn product complex | | Descriptor: | ADENOSINE MONOPHOSPHATE, Aprataxin, DNA (5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3'), ... | | Authors: | Schellenberg, M.J, Tumbale, P.S, Williams, R.S. | | Deposit date: | 2018-03-28 | | Release date: | 2018-07-04 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.941 Å) | | Cite: | Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
EMBO J., 37, 2018
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7T8B
 | | Octameric Human Twinkle Helicase Clinical Variant W315L | | Descriptor: | Twinkle mtDNA helicase | | Authors: | Riccio, A.A, Bouvette, J, Krahn, J, Borgnia, M.J, Copeland, W.C. | | Deposit date: | 2021-12-16 | | Release date: | 2022-07-27 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structural insight and characterization of human Twinkle helicase in mitochondrial disease.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7T8C
 | | Heptameric Human Twinkle Helicase Clinical Variant W315L | | Descriptor: | Twinkle mtDNA helicase | | Authors: | Riccio, A.A, Bouvette, J, Krahn, J, Borgnia, M.J, Copeland, W.C. | | Deposit date: | 2021-12-16 | | Release date: | 2022-07-27 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Structural insight and characterization of human Twinkle helicase in mitochondrial disease.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7N3Z
 | | Crystal Structure of Saccharomyces cerevisiae Apn2 Catalytic Domain | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DNA-(apurinic or apyrimidinic site) endonuclease 2, ... | | Authors: | Wojtaszek, J.L, Wallace, B.D, Williams, R.S. | | Deposit date: | 2021-06-02 | | Release date: | 2022-09-28 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Molecular basis for processing of topoisomerase 1-triggered DNA damage by Apn2/APE2.
Cell Rep, 41, 2022
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6CVP
 | | Human Aprataxin (Aptx) R199H bound to RNA-DNA, AMP and Zn product complex | | Descriptor: | ADENOSINE MONOPHOSPHATE, Aprataxin, DNA (5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3'), ... | | Authors: | Schellenberg, M.J, Williams, R.S, Tumbale, P.S. | | Deposit date: | 2018-03-28 | | Release date: | 2018-07-04 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.999 Å) | | Cite: | Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
EMBO J., 37, 2018
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6CVS
 | | Human Aprataxin (Aptx) L248M bound to DNA, AMP and Zn product | | Descriptor: | ADENOSINE MONOPHOSPHATE, Aprataxin, BETA-MERCAPTOETHANOL, ... | | Authors: | Schellenberg, M.J, Tumbale, P.S, Williams, R.S. | | Deposit date: | 2018-03-28 | | Release date: | 2018-07-04 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.11 Å) | | Cite: | Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
EMBO J., 37, 2018
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6CVQ
 | | Human Aprataxin (Aptx) H201Q bound to RNA-DNA, AMP and Zn product complex | | Descriptor: | ADENOSINE MONOPHOSPHATE, Aprataxin, BETA-MERCAPTOETHANOL, ... | | Authors: | Schellenberg, M.J, Tumbale, P.S, Williams, R.S. | | Deposit date: | 2018-03-28 | | Release date: | 2018-07-04 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
EMBO J., 37, 2018
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6CVR
 | | Human Aprataxin (Aptx) S242N bound to RNA-DNA, AMP and Zn product complex | | Descriptor: | ADENOSINE MONOPHOSPHATE, Aprataxin, DNA (5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3'), ... | | Authors: | Schellenberg, M.J, Tumbale, P.S, Williams, R.S. | | Deposit date: | 2018-03-28 | | Release date: | 2018-07-04 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
EMBO J., 37, 2018
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6CVO
 | | Human Aprataxin (Aptx) bound to nicked RNA-DNA, AMP and Zn product complex | | Descriptor: | ADENOSINE MONOPHOSPHATE, Aprataxin, BETA-MERCAPTOETHANOL, ... | | Authors: | Schellenberg, M.J, Tumbale, P.P, Williams, R.S. | | Deposit date: | 2018-03-28 | | Release date: | 2018-08-29 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.
EMBO J., 37, 2018
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7SWL
 | | CryoEM structure of the N-terminal-deleted Rix7 AAA-ATPase | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Kocaman, S, Stanley, R.E, Lo, Y.H, Krahn, J, Dandey, V.P, Sobhany, M, Petrovich, M, Williams, J.G, Deterding, L.J, Borgnia, M.J, Etigunta, S. | | Deposit date: | 2021-11-20 | | Release date: | 2022-03-02 | | Last modified: | 2023-03-15 | | Method: | ELECTRON MICROSCOPY (2.88 Å) | | Cite: | Communication network within the essential AAA-ATPase Rix7 drives ribosome assembly.
Pnas Nexus, 1, 2022
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7T0V
 | | CryoEM structure of the crosslinked Rix7 AAA-ATPase | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Kocaman, S, Stanley, R.E, Lo, Y.H, Krahn, J, Dandey, V.P, Sobhany, M, Petrovich, M, Williams, J.G, Deterding, L.J, Borgnia, M.J, Etigunta, S. | | Deposit date: | 2021-11-30 | | Release date: | 2022-03-02 | | Last modified: | 2023-03-15 | | Method: | ELECTRON MICROSCOPY (3.67 Å) | | Cite: | Communication network within the essential AAA-ATPase Rix7 drives ribosome assembly.
Pnas Nexus, 1, 2022
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