6CVP
Human Aprataxin (Aptx) R199H bound to RNA-DNA, AMP and Zn product complex
Summary for 6CVP
Entry DOI | 10.2210/pdb6cvp/pdb |
Related | 4NDF |
Descriptor | Aprataxin, DNA/RNA (5'-R(P*G)-D(P*TP*TP*AP*TP*GP*AP*TP*TP*C)-3'), DNA (5'-D(*GP*AP*AP*TP*CP*AP*TP*AP*AP*C)-3'), ... (7 entities in total) |
Functional Keywords | protein-dna complex, dna repair, 5'-dna end processing, histidine triad domain, hit domain, zinc-finger, 5'-dna end recognition, hydrolase, hydrolase-dna-rna complex, hydrolase/dna/rna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 55535.76 |
Authors | Schellenberg, M.J.,Williams, R.S.,Tumbale, P.S. (deposition date: 2018-03-28, release date: 2018-07-04, Last modification date: 2023-10-04) |
Primary citation | Tumbale, P.,Schellenberg, M.J.,Mueller, G.A.,Fairweather, E.,Watson, M.,Little, J.N.,Krahn, J.,Waddell, I.,London, R.E.,Williams, R.S. Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease. EMBO J., 37:-, 2018 Cited by PubMed: 29934293DOI: 10.15252/embj.201798875 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.999 Å) |
Structure validation
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