6CVP
Human Aprataxin (Aptx) R199H bound to RNA-DNA, AMP and Zn product complex
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue AMP A 401 |
| Chain | Residue |
| A | GLY170 |
| A | HIS251 |
| A | PRO254 |
| A | SER255 |
| A | MET256 |
| A | HIS260 |
| A | HIS262 |
| A | HOH523 |
| A | HOH543 |
| D | G1 |
| D | HOH101 |
| A | LEU171 |
| A | SER174 |
| A | LYS192 |
| A | ASP193 |
| A | LYS194 |
| A | TYR195 |
| A | LYS197 |
| A | LEU203 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 402 |
| Chain | Residue |
| A | CYS319 |
| A | CYS322 |
| A | HIS335 |
| A | HIS339 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | binding site for residue AMP B 401 |
| Chain | Residue |
| B | LEU171 |
| B | SER174 |
| B | LYS192 |
| B | ASP193 |
| B | LYS194 |
| B | TYR195 |
| B | LYS197 |
| B | LEU203 |
| B | HIS251 |
| B | PRO254 |
| B | SER255 |
| B | MET256 |
| B | HIS260 |
| B | HIS262 |
| B | HOH503 |
| B | HOH542 |
| B | HOH610 |
| G | G1 |
| G | HOH106 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 402 |
| Chain | Residue |
| B | CYS319 |
| B | CYS322 |
| B | HIS335 |
| B | HIS339 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 403 |
| Chain | Residue |
| B | SER255 |
| B | HOH660 |
| B | HOH669 |
| B | HOH711 |
| G | HOH118 |
| G | HOH121 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 210 |
| Details | Domain: {"description":"HIT","evidences":[{"source":"PROSITE-ProRule","id":"PRU00464","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | Zinc finger: {"description":"C2H2-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17276982","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24362567","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Region: {"description":"Interaction with DNA substrate","evidences":[{"source":"PubMed","id":"24362567","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Histidine triad motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00464","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24362567","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Tele-AMP-histidine intermediate","evidences":[{"source":"PubMed","id":"24362567","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Site: {"description":"Interaction with DNA substrate","evidences":[{"source":"PubMed","id":"24362567","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
