6CVS
Human Aprataxin (Aptx) L248M bound to DNA, AMP and Zn product
Summary for 6CVS
Entry DOI | 10.2210/pdb6cvs/pdb |
Related | 4NDH |
Descriptor | Aprataxin, DNA (5'-D(P*GP*TP*TP*CP*TP*AP*GP*AP*AP*C)-3'), ADENOSINE MONOPHOSPHATE, ... (6 entities in total) |
Functional Keywords | protein-dna complex, dna repair, 5'-dna end processing, histidine triad domain, hit domain, zinc-finger, 5'-dna end recognition, hydrolase, hydrolase-dna-rna complex, hydrolase-dna complex, hydrolase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 55713.18 |
Authors | Schellenberg, M.J.,Tumbale, P.S.,Williams, R.S. (deposition date: 2018-03-28, release date: 2018-07-04, Last modification date: 2023-10-04) |
Primary citation | Tumbale, P.,Schellenberg, M.J.,Mueller, G.A.,Fairweather, E.,Watson, M.,Little, J.N.,Krahn, J.,Waddell, I.,London, R.E.,Williams, R.S. Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease. EMBO J., 37:-, 2018 Cited by PubMed: 29934293DOI: 10.15252/embj.201798875 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.11 Å) |
Structure validation
Download full validation report