6CVS

Human Aprataxin (Aptx) L248M bound to DNA, AMP and Zn product

Summary for 6CVS

• Entry DOI: 10.2210/pdb6cvs/pdb
• Related: 4NDH
• Descriptor: Aprataxin, DNA (5'-D(P*GP*TP*TP*CP*TP*AP*GP*AP*AP*C)-3'), ADENOSINE MONOPHOSPHATE, ... (6 entities in total)
• Functional Keywords: protein-dna complex, dna repair, 5'-dna end processing, histidine triad domain, hit domain, zinc-finger, 5'-dna end recognition, hydrolase, hydrolase-dna-rna complex, hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 55713.18

Authors

Schellenberg, M.J.,Tumbale, P.S.,Williams, R.S. (deposition date: 2018-03-28, release date: 2018-07-04, Last modification date: 2023-10-04)

• Primary citation: Tumbale, P.,Schellenberg, M.J.,Mueller, G.A.,Fairweather, E.,Watson, M.,Little, J.N.,Krahn, J.,Waddell, I.,London, R.E.,Williams, R.S.; Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease.; EMBO J., 37:-, 2018; PubMed: 29934293; DOI: 10.15252/embj.201798875

Experimental method

X-RAY DIFFRACTION (2.11 Å)