6CVS
Human Aprataxin (Aptx) L248M bound to DNA, AMP and Zn product
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Aprataxin | polymer | 182 | 21277.8 | 2 | UniProt (Q7Z2E3) Pfam (PF11969) Pfam (PF16278) In PDB | Homo sapiens (Human) | Forkhead-associated domain histidine triad-like protein,FHA-HIT |
| 2 | D, E, G, H | DNA (5'-D(P*GP*TP*TP*CP*TP*AP*GP*AP*AP*C)-3') | polymer | 10 | 3044.0 | 4 | Homo sapiens | ||
| 3 | A, B | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 2 | Chemie (AMP) | |||
| 4 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | A, B | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 2 | Chemie (BME) | |||
| 6 | water | water | 18.0 | 498 | Chemie (HOH) |
Sequence modifications
A, B: 165 - 342 (UniProt: Q7Z2E3)
| PDB | External Database | Details |
|---|---|---|
| Gly 161 | - | expression tag |
| Ser 162 | - | expression tag |
| His 163 | - | expression tag |
| Met 164 | - | expression tag |
| Met 248 | Leu 262 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 54731.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 981.5 | |
| All* | Total formula weight | 55713.2 |
