7T8B

Octameric Human Twinkle Helicase Clinical Variant W315L

Summary for 7T8B

Entry DOI	10.2210/pdb7t8b/pdb
EMDB information	25743
Descriptor	Twinkle mtDNA helicase (1 entity in total)
Functional Keywords	helicase, walker a, walker b, dna binding, dna binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	8
Total formula weight	627755.38
Authors	Riccio, A.A.,Bouvette, J.,Krahn, J.,Borgnia, M.J.,Copeland, W.C. (deposition date: 2021-12-16, release date: 2022-07-27, Last modification date: 2024-02-28)
Primary citation	Riccio, A.A.,Bouvette, J.,Perera, L.,Longley, M.J.,Krahn, J.M.,Williams, J.G.,Dutcher, R.,Borgnia, M.J.,Copeland, W.C. Structural insight and characterization of human Twinkle helicase in mitochondrial disease. Proc.Natl.Acad.Sci.USA, 119:e2207459119-e2207459119, 2022 Cited by PubMed: 35914129 DOI: 10.1073/pnas.2207459119 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.8 Å)

Structure validation