7T8B

Octameric Human Twinkle Helicase Clinical Variant W315L

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002020	molecular_function	protease binding
A	0003678	molecular_function	DNA helicase activity
A	0003697	molecular_function	single-stranded DNA binding
A	0004386	molecular_function	helicase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005759	cellular_component	mitochondrial matrix
A	0006260	biological_process	DNA replication
A	0006264	biological_process	mitochondrial DNA replication
A	0006268	biological_process	DNA unwinding involved in DNA replication
A	0006390	biological_process	mitochondrial transcription
A	0008289	molecular_function	lipid binding
A	0016787	molecular_function	hydrolase activity
A	0016853	molecular_function	isomerase activity
A	0016887	molecular_function	ATP hydrolysis activity
A	0034214	biological_process	protein hexamerization
A	0042645	cellular_component	mitochondrial nucleoid
A	0042802	molecular_function	identical protein binding
A	0043139	molecular_function	5'-3' DNA helicase activity
A	0071333	biological_process	cellular response to glucose stimulus
B	0002020	molecular_function	protease binding
B	0003678	molecular_function	DNA helicase activity
B	0003697	molecular_function	single-stranded DNA binding
B	0004386	molecular_function	helicase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005759	cellular_component	mitochondrial matrix
B	0006260	biological_process	DNA replication
B	0006264	biological_process	mitochondrial DNA replication
B	0006268	biological_process	DNA unwinding involved in DNA replication
B	0006390	biological_process	mitochondrial transcription
B	0008289	molecular_function	lipid binding
B	0016787	molecular_function	hydrolase activity
B	0016853	molecular_function	isomerase activity
B	0016887	molecular_function	ATP hydrolysis activity
B	0034214	biological_process	protein hexamerization
B	0042645	cellular_component	mitochondrial nucleoid
B	0042802	molecular_function	identical protein binding
B	0043139	molecular_function	5'-3' DNA helicase activity
B	0071333	biological_process	cellular response to glucose stimulus
C	0002020	molecular_function	protease binding
C	0003678	molecular_function	DNA helicase activity
C	0003697	molecular_function	single-stranded DNA binding
C	0004386	molecular_function	helicase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005759	cellular_component	mitochondrial matrix
C	0006260	biological_process	DNA replication
C	0006264	biological_process	mitochondrial DNA replication
C	0006268	biological_process	DNA unwinding involved in DNA replication
C	0006390	biological_process	mitochondrial transcription
C	0008289	molecular_function	lipid binding
C	0016787	molecular_function	hydrolase activity
C	0016853	molecular_function	isomerase activity
C	0016887	molecular_function	ATP hydrolysis activity
C	0034214	biological_process	protein hexamerization
C	0042645	cellular_component	mitochondrial nucleoid
C	0042802	molecular_function	identical protein binding
C	0043139	molecular_function	5'-3' DNA helicase activity
C	0071333	biological_process	cellular response to glucose stimulus
D	0002020	molecular_function	protease binding
D	0003678	molecular_function	DNA helicase activity
D	0003697	molecular_function	single-stranded DNA binding
D	0004386	molecular_function	helicase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005759	cellular_component	mitochondrial matrix
D	0006260	biological_process	DNA replication
D	0006264	biological_process	mitochondrial DNA replication
D	0006268	biological_process	DNA unwinding involved in DNA replication
D	0006390	biological_process	mitochondrial transcription
D	0008289	molecular_function	lipid binding
D	0016787	molecular_function	hydrolase activity
D	0016853	molecular_function	isomerase activity
D	0016887	molecular_function	ATP hydrolysis activity
D	0034214	biological_process	protein hexamerization
D	0042645	cellular_component	mitochondrial nucleoid
D	0042802	molecular_function	identical protein binding
D	0043139	molecular_function	5'-3' DNA helicase activity
D	0071333	biological_process	cellular response to glucose stimulus
E	0002020	molecular_function	protease binding
E	0003678	molecular_function	DNA helicase activity
E	0003697	molecular_function	single-stranded DNA binding
E	0004386	molecular_function	helicase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005759	cellular_component	mitochondrial matrix
E	0006260	biological_process	DNA replication
E	0006264	biological_process	mitochondrial DNA replication
E	0006268	biological_process	DNA unwinding involved in DNA replication
E	0006390	biological_process	mitochondrial transcription
E	0008289	molecular_function	lipid binding
E	0016787	molecular_function	hydrolase activity
E	0016853	molecular_function	isomerase activity
E	0016887	molecular_function	ATP hydrolysis activity
E	0034214	biological_process	protein hexamerization
E	0042645	cellular_component	mitochondrial nucleoid
E	0042802	molecular_function	identical protein binding
E	0043139	molecular_function	5'-3' DNA helicase activity
E	0071333	biological_process	cellular response to glucose stimulus
F	0002020	molecular_function	protease binding
F	0003678	molecular_function	DNA helicase activity
F	0003697	molecular_function	single-stranded DNA binding
F	0004386	molecular_function	helicase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005759	cellular_component	mitochondrial matrix
F	0006260	biological_process	DNA replication
F	0006264	biological_process	mitochondrial DNA replication
F	0006268	biological_process	DNA unwinding involved in DNA replication
F	0006390	biological_process	mitochondrial transcription
F	0008289	molecular_function	lipid binding
F	0016787	molecular_function	hydrolase activity
F	0016853	molecular_function	isomerase activity
F	0016887	molecular_function	ATP hydrolysis activity
F	0034214	biological_process	protein hexamerization
F	0042645	cellular_component	mitochondrial nucleoid
F	0042802	molecular_function	identical protein binding
F	0043139	molecular_function	5'-3' DNA helicase activity
F	0071333	biological_process	cellular response to glucose stimulus
G	0002020	molecular_function	protease binding
G	0003678	molecular_function	DNA helicase activity
G	0003697	molecular_function	single-stranded DNA binding
G	0004386	molecular_function	helicase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0005759	cellular_component	mitochondrial matrix
G	0006260	biological_process	DNA replication
G	0006264	biological_process	mitochondrial DNA replication
G	0006268	biological_process	DNA unwinding involved in DNA replication
G	0006390	biological_process	mitochondrial transcription
G	0008289	molecular_function	lipid binding
G	0016787	molecular_function	hydrolase activity
G	0016853	molecular_function	isomerase activity
G	0016887	molecular_function	ATP hydrolysis activity
G	0034214	biological_process	protein hexamerization
G	0042645	cellular_component	mitochondrial nucleoid
G	0042802	molecular_function	identical protein binding
G	0043139	molecular_function	5'-3' DNA helicase activity
G	0071333	biological_process	cellular response to glucose stimulus
H	0002020	molecular_function	protease binding
H	0003678	molecular_function	DNA helicase activity
H	0003697	molecular_function	single-stranded DNA binding
H	0004386	molecular_function	helicase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0005759	cellular_component	mitochondrial matrix
H	0006260	biological_process	DNA replication
H	0006264	biological_process	mitochondrial DNA replication
H	0006268	biological_process	DNA unwinding involved in DNA replication
H	0006390	biological_process	mitochondrial transcription
H	0008289	molecular_function	lipid binding
H	0016787	molecular_function	hydrolase activity
H	0016853	molecular_function	isomerase activity
H	0016887	molecular_function	ATP hydrolysis activity
H	0034214	biological_process	protein hexamerization
H	0042645	cellular_component	mitochondrial nucleoid
H	0042802	molecular_function	identical protein binding
H	0043139	molecular_function	5'-3' DNA helicase activity
H	0071333	biological_process	cellular response to glucose stimulus

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00596

Chain	Residue	Details
A	GLY415
B	GLY415
C	GLY415
D	GLY415
E	GLY415
F	GLY415
G	GLY415
H	GLY415

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