7T8B

Octameric Human Twinkle Helicase Clinical Variant W315L

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Twinkle mtDNA helicase	polymer	695	78469.4	8	UniProt (Q96RR1) Pfam (PF13481) In PDB	Homo sapiens (human)	Progressive external ophthalmoplegia 1 protein,T7 gp4-like protein with intramitochondrial nucleoid localization,T7-like mitochondrial DNA helicase,Twinkle protein,mitochondrial

Sequence modifications

A, B, C, D, E, F, G, H: 1 - 684 (UniProt: Q96RR1)

PDB	External Database	Details
Leu 315	Trp 315	variant
Ala 685	-	expression tag
Ala 686	-	expression tag
Ala 687	-	expression tag
Leu 688	-	expression tag
Glu 689	-	expression tag
His 690	-	expression tag
His 691	-	expression tag
His 692	-	expression tag
His 693	-	expression tag
His 694	-	expression tag
His 695	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	627755.4
All*	Total formula weight	627755.4

*Water molecules are not included.