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6EO1
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BU of 6eo1 by Molmil
The electron crystallography structure of the cAMP-bound potassium channel MloK1 (PCO-refined)
Descriptor: Cyclic nucleotide-gated potassium channel mll3241, POTASSIUM ION
Authors:Kowal, J, Biyani, N, Chami, M, Scherer, S, Rzepiela, A, Baumgartner, P, Upadhyay, V, Nimigean, C, Stahlberg, H.
Deposit date:2017-10-08
Release date:2017-12-27
Last modified:2024-05-15
Method:ELECTRON CRYSTALLOGRAPHY (4.5 Å)
Cite:High-Resolution Cryoelectron Microscopy Structure of the Cyclic Nucleotide-Modulated Potassium Channel MloK1 in a Lipid Bilayer.
Structure, 26, 2018
4CHW
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BU of 4chw by Molmil
The electron crystallography structure of the cAMP-free potassium channel MloK1
Descriptor: CYCLIC NUCLEOTIDE-GATED POTASSIUM CHANNEL MLL3241, POTASSIUM ION
Authors:Kowal, J, Chami, M, Baumgartner, P, Arheit, M, Chiu, P.L, Rangl, M, Scheuring, S, Schroeder, G.F, Nimigean, C.M, Stahlberg, H.
Deposit date:2013-12-04
Release date:2014-01-15
Last modified:2024-05-08
Method:ELECTRON CRYSTALLOGRAPHY (7 Å)
Cite:Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1.
Nat Commun, 5, 2014
4CHV
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BU of 4chv by Molmil
The electron crystallography structure of the cAMP-bound potassium channel MloK1
Descriptor: CYCLIC NUCLEOTIDE-GATED POTASSIUM CHANNEL MLL3241, POTASSIUM ION
Authors:Kowal, J, Chami, M, Baumgartner, P, Arheit, M, Chiu, P.L, Rangl, M, Scheuring, S, Schroeder, G.F, Nimigean, C.M, Stahlberg, H.
Deposit date:2013-12-04
Release date:2014-01-15
Last modified:2024-05-08
Method:ELECTRON CRYSTALLOGRAPHY (7 Å)
Cite:Ligand-Induced Structural Changes in the Cyclic Nucleotide-Modulated Potassium Channel Mlok1
Nat.Commun., 5, 2014
7NEZ
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BU of 7nez by Molmil
Structure of topotecan-bound ABCG2
Descriptor: (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, ...
Authors:Kowal, J, Locher, K, Ni, D, Stahlberg, H.
Deposit date:2021-02-05
Release date:2021-04-21
Last modified:2021-05-12
Method:ELECTRON MICROSCOPY (3.39 Å)
Cite:Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2.
J.Mol.Biol., 433, 2021
7NFD
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BU of 7nfd by Molmil
Structure of mitoxantrone-bound ABCG2
Descriptor: 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, ...
Authors:Kowal, J, Locher, K, Ni, D, Stahlberg, H.
Deposit date:2021-02-06
Release date:2021-04-21
Last modified:2021-05-12
Method:ELECTRON MICROSCOPY (3.51 Å)
Cite:Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2.
J.Mol.Biol., 433, 2021
7NEQ
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BU of 7neq by Molmil
Structure of tariquidar-bound ABCG2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ...
Authors:Kowal, J, Locher, K.
Deposit date:2021-02-04
Release date:2021-04-21
Last modified:2021-05-12
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2.
J.Mol.Biol., 433, 2021
6EZN
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BU of 6ezn by Molmil
Cryo-EM structure of the yeast oligosaccharyltransferase (OST) complex
Descriptor: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Wild, R, Kowal, J, Eyring, J, Ngwa, E.M, Aebi, M, Locher, K.P.
Deposit date:2017-11-16
Release date:2018-01-17
Last modified:2022-12-07
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Molecular basis for glycan recognition and reaction priming of eukaryotic oligosaccharyltransferase.
Nat Commun, 13, 2022
6I9D
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BU of 6i9d by Molmil
MloK1 consensus structure from single particle analysis of 2D crystals
Descriptor: Cyclic nucleotide-gated potassium channel mll3241, POTASSIUM ION
Authors:Righetto, R, Biyani, N, Kowal, J, Chami, M, Stahlberg, H.
Deposit date:2018-11-23
Release date:2019-04-24
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Retrieving high-resolution information from disordered 2D crystals by single-particle cryo-EM.
Nat Commun, 10, 2019
6IAX
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BU of 6iax by Molmil
MloK1 model from single particle analysis of 2D crystals, class 1 (extended conformation)
Descriptor: Cyclic nucleotide-gated potassium channel mll3241, POTASSIUM ION
Authors:Righetto, R, Biyani, N, Kowal, J, Chami, M, Stahlberg, H.
Deposit date:2018-11-27
Release date:2019-04-24
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (5.2 Å)
Cite:Retrieving high-resolution information from disordered 2D crystals by single-particle cryo-EM.
Nat Commun, 10, 2019
6ETI
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BU of 6eti by Molmil
Structure of inhibitor-bound ABCG2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3(Fab) heavy chain variable domain, 5D3(Fab) light chain variable domain, ...
Authors:Jackson, S.M, Manolaridis, I, Kowal, J, Zechner, M, Altmann, K.H, Locher, K.P.
Deposit date:2017-10-26
Release date:2018-04-11
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of small-molecule inhibition of human multidrug transporter ABCG2.
Nat. Struct. Mol. Biol., 25, 2018
7PHP
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BU of 7php by Molmil
Structure of Multidrug and Toxin Compound Extrusion (MATE) transporter NorM by NabFab-fiducial assisted cryo-EM
Descriptor: Anti-Fab nanobody, Multidrug resistance protein NorM, NabFab HC, ...
Authors:Bloch, J.S, Mukherjee, S, Kowal, J, Niederer, M, Pardon, E, Steyaert, J, Kossiakoff, A.A, Locher, K.P.
Deposit date:2021-08-18
Release date:2021-09-01
Last modified:2021-12-01
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
7PIJ
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BU of 7pij by Molmil
Structure of Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM
Descriptor: Anti-Fab nanobody, DMTNb16_4, Divalent metal cation transporter MntH, ...
Authors:Bloch, J.S, Mukherjee, S, Kowal, J, Kossiakoff, A.A, Locher, K.P.
Deposit date:2021-08-20
Release date:2021-09-01
Last modified:2021-12-01
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
7PHQ
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BU of 7phq by Molmil
Structure of homo-dimeric Staphylococcus capitis divalent metal ion transporter (DMT) by NabFab-fiducial assisted cryo-EM
Descriptor: Anti-Fab nanobody, DMT-Nb16_4, Divalent metal cation transporter MntH, ...
Authors:Bloch, J.S, Mukherjee, S, Kowal, J, Kossiakoff, A.A, Locher, K.P.
Deposit date:2021-08-18
Release date:2021-09-01
Last modified:2021-12-01
Method:ELECTRON MICROSCOPY (8.45 Å)
Cite:Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins.
Proc.Natl.Acad.Sci.USA, 118, 2021
7OCI
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BU of 7oci by Molmil
Cryo-EM structure of yeast Ost6p containing oligosaccharyltransferase complex
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Wild, R, Neuhaus, J.D, Eyring, J, Irobalieva, R.N, Kowal, J, Lin, C.W, Locher, K.P, Aebi, M.
Deposit date:2021-04-27
Release date:2022-02-16
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Functional analysis of Ost3p and Ost6p containing yeast oligosaccharyltransferases.
Glycobiology, 31, 2021
5NJG
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BU of 5njg by Molmil
Structure of an ABC transporter: part of the structure that could be built de novo
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3-Fab heavy chain, 5D3-Fab light chain, ...
Authors:Taylor, N.M.I, Manolaridis, I, Jackson, S.M, Kowal, J, Stahlberg, H, Locher, K.P.
Deposit date:2017-03-28
Release date:2017-06-07
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:Structure of the human multidrug transporter ABCG2.
Nature, 546, 2017
7OJ8
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BU of 7oj8 by Molmil
ABCG2 E1S turnover-2 state
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL, ...
Authors:Ni, D, Yu, Q, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P.
Deposit date:2021-05-14
Release date:2021-07-21
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism.
Nat Commun, 12, 2021
7OJH
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BU of 7ojh by Molmil
ABCG2 topotecan turnover-1 state
Descriptor: (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, ...
Authors:Yu, Q, Ni, D, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P.
Deposit date:2021-05-15
Release date:2021-07-21
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism.
Nat Commun, 12, 2021
7OJI
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BU of 7oji by Molmil
ABCG2 topotecan turnover-2 state
Descriptor: (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, ...
Authors:Yu, Q, Ni, D, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P.
Deposit date:2021-05-16
Release date:2021-07-21
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism.
Nat Commun, 12, 2021
7OZ1
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BU of 7oz1 by Molmil
Cryo-EM structure of ABCG1 E242Q mutant with ATP and cholesteryl hemisuccinate bound
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL HEMISUCCINATE, ...
Authors:Skarda, L, Kowal, J, Locher, K.P.
Deposit date:2021-06-25
Release date:2021-09-22
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structure of the Human Cholesterol Transporter ABCG1.
J.Mol.Biol., 433, 2021
5NJ3
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BU of 5nj3 by Molmil
Structure of an ABC transporter: complete structure
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5D3-Fab heavy chain, 5D3-Fab light chain, ...
Authors:Taylor, N.M.I, Manolaridis, I, Jackson, S.M, Kowal, J, Stahlberg, H, Locher, K.P.
Deposit date:2017-03-28
Release date:2017-06-07
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.78 Å)
Cite:Structure of the human multidrug transporter ABCG2.
Nature, 546, 2017
2N5E
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BU of 2n5e by Molmil
The 3D solution structure of discoidal high-density lipoprotein particles
Descriptor: Apolipoprotein A-I
Authors:Bibow, S, Polyhach, Y, Eichmann, C, Chi, C.N, Kowal, J, Stahlberg, H, Jeschke, G, Guentert, P, Riek, R.
Deposit date:2015-07-15
Release date:2016-12-21
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Solution structure of discoidal high-density lipoprotein particles with a shortened apolipoprotein A-I.
Nat.Struct.Mol.Biol., 24, 2017
8PG0
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BU of 8pg0 by Molmil
Human OATP1B3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, CHOLESTEROL, ...
Authors:Ciuta, A.-D, Nosol, K, Kowal, J, Mukherjee, S, Ramirez, A.S, Stieger, B, Kossiakoff, A.A, Locher, K.P.
Deposit date:2023-06-17
Release date:2023-09-27
Method:ELECTRON MICROSCOPY (2.97 Å)
Cite:Structure of human drug transporters OATP1B1 and OATP1B3.
Nat Commun, 14, 2023
8PHW
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BU of 8phw by Molmil
Human OATP1B1
Descriptor: CHOLESTEROL HEMISUCCINATE, Fab18 (heavy chain, variable region), ...
Authors:Ciuta, A.-D, Nosol, K, Kowal, J, Mukherjee, S, Ramirez, A.S, Stieger, B, Kossiakoff, A.A, Locher, K.P.
Deposit date:2023-06-20
Release date:2023-09-27
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure of human drug transporters OATP1B1 and OATP1B3.
Nat Commun, 14, 2023
8PM6
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BU of 8pm6 by Molmil
Human bile salt export pump (BSEP) in complex with inhibitor GBM in nanodiscs
Descriptor: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, Bile salt export pump, CHOLESTEROL
Authors:Liu, H, Irobalieva, R.N, Kowal, J, Ni, D, Nosol, K, Bang-Sorensen, R, Lancien, L, Stahlberg, H, Stieger, B, Locher, K.P.
Deposit date:2023-06-28
Release date:2023-11-22
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP.
Nat Commun, 14, 2023
8PMJ
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BU of 8pmj by Molmil
Vanadate-trapped BSEP in nanodiscs
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Bile salt export pump, ...
Authors:Liu, H, Irobalieva, R.N, Kowal, J, Ni, D, Nosol, K, Bang-Sorensen, R, Lancien, L, Stahlberg, H, Stieger, B, Locher, K.P.
Deposit date:2023-06-28
Release date:2023-11-29
Method:ELECTRON MICROSCOPY (2.81 Å)
Cite:Structural basis of bile salt extrusion and small-molecule inhibition in human BSEP.
Nat Commun, 14, 2023

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