7NEQ

Structure of tariquidar-bound ABCG2

Summary for 7NEQ

• Entry DOI: 10.2210/pdb7neq/pdb
• EMDB information: 12290
• Descriptor: ATP-binding cassette sub-family G member 2, 5D3(Fab) light chain variable domain, 5D3(Fab) heavy chain variable domain, ... (8 entities in total)
• Functional Keywords: abcg2, tariquidar, substrate, abc transporter, anticancer drugs, cavity 1, cryo-em, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 242531.96

Authors

Kowal, J.,Locher, K. (deposition date: 2021-02-04, release date: 2021-04-21, Last modification date: 2021-05-12)

• Primary citation: Kowal, J.,Ni, D.,Jackson, S.M.,Manolaridis, I.,Stahlberg, H.,Locher, K.P.; Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2.; J.Mol.Biol., 433:166980-166980, 2021; PubMed: 33838147; DOI: 10.1016/j.jmb.2021.166980

Experimental method

ELECTRON MICROSCOPY (3.12 Å)