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3EVS
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BU of 3evs by Molmil
Crystal structure of the GDF-5:BMP receptor IB complex.
Descriptor: Bone morphogenetic protein receptor type-1B, Growth/differentiation factor 5
Authors:Kotzsch, A, Mueller, T.D.
Deposit date:2008-10-13
Release date:2009-03-10
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity.
Embo J., 28, 2009
2QJB
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BU of 2qjb by Molmil
Crystal structure analysis of BMP-2 in complex with BMPR-IA variant IA/IB
Descriptor: Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA, CHLORIDE ION
Authors:Kotzsch, A, Mueller, T.D.
Deposit date:2007-07-06
Release date:2008-01-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome.
J.Biol.Chem., 283, 2008
2QJA
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BU of 2qja by Molmil
Crystal structure analysis of BMP-2 in complex with BMPR-IA variant B12
Descriptor: Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA
Authors:Kotzsch, A, Mueller, T.D.
Deposit date:2007-07-06
Release date:2008-01-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome.
J.Biol.Chem., 283, 2008
2QJ9
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BU of 2qj9 by Molmil
Crystal structure analysis of BMP-2 in complex with BMPR-IA variant B1
Descriptor: Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA
Authors:Kotzsch, A, Mueller, T.D.
Deposit date:2007-07-06
Release date:2008-01-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome.
J.Biol.Chem., 283, 2008
3KVH
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BU of 3kvh by Molmil
Crystal structure of human protein syndesmos (NUDT16-like protein)
Descriptor: CHLORIDE ION, GLYCEROL, Protein syndesmos
Authors:Tresaugues, L, Siponen, M.I, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kallas, A, Karlberg, T, Kotenyova, T, Kotzsch, A, Kraulis, P, Moche, M, Nielsen, T.K, Nyman, T, Persson, C, Roos, A.K, Schuler, H, Schutz, P, Thorsell, A.G, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Nordlund, P, Structural Genomics Consortium (SGC)
Deposit date:2009-11-30
Release date:2010-01-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of human protein syndesmos (NUDT16L1)
To be Published
3QT2
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BU of 3qt2 by Molmil
Structure of a cytokine ligand-receptor complex
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Interleukin-5, Interleukin-5 receptor subunit alpha, ...
Authors:Mueller, T.D, Patino, E, Kotzsch, A, Saremba, S, Nickel, J, Schmitz, W, Sebald, W.
Deposit date:2011-02-22
Release date:2012-02-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure Analysis of the IL-5 Ligand-Receptor Complex Reveals a Wrench-like Architecture for IL-5Ralpha.
Structure, 19, 2011
2K3G
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BU of 2k3g by Molmil
NMR structure analysis of a BMP receptor
Descriptor: Bone morphogenetic protein receptor type-1A
Authors:Klages, J, Kotzsch, A, Mueller, T, Kessler, H.
Deposit date:2008-05-07
Release date:2008-12-16
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:The solution structure of BMPR-IA reveals a local disorder-to-order transition upon BMP-2 binding.
Biochemistry, 47, 2008
3IQ2
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BU of 3iq2 by Molmil
Human sorting nexin 7, phox homology (PX) domain
Descriptor: GLYCEROL, SULFATE ION, Sorting nexin-7
Authors:Karlberg, T, Wisniewska, M, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kallas, A, Kotenyova, T, Kotzsch, A, Kraulis, P, Nielsen, T.K, Moche, M, Nordlund, P, Nyman, T, Persson, C, Roos, A.K, Schutz, P, Siponen, M.I, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Schuler, H, Structural Genomics Consortium (SGC)
Deposit date:2009-08-19
Release date:2009-09-08
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Human Sorting Nexin 7, Phox Homology (Px) Domain
To be Published
3K2I
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BU of 3k2i by Molmil
Human Acyl-coenzyme A thioesterase 4
Descriptor: Acyl-coenzyme A thioesterase 4, CHLORIDE ION, NICKEL (II) ION
Authors:Siponen, M.I, Moche, M, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kallas, A, Karlberg, T, Kraulis, P, Kotenyova, T, Kotzsch, A, Markova, N, Nielsen, T.K, Nordlund, P, Nyman, T, Persson, C, Roos, A.K, Schutz, P, Svensson, L, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Wahlberg, E, Weigelt, J, Welin, M, Wisniewska, M, Schuler, H, Structural Genomics Consortium (SGC)
Deposit date:2009-09-30
Release date:2009-10-20
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Human Acyl-coenzyme A thioesterase 4
To be Published
3IHY
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BU of 3ihy by Molmil
Human PIK3C3 crystal structure
Descriptor: Phosphatidylinositol 3-kinase catalytic subunit type 3
Authors:Siponen, M.I, Tresaugues, L, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kotenyova, T, Kotzsch, A, Kragh Nielsen, T, Moche, M, Nyman, T, Persson, C, Roos, A.K, Sagemark, J, Schueler, H, Schutz, P, Thorsell, A.G, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Nordlund, P, Structural Genomics Consortium (SGC)
Deposit date:2009-07-31
Release date:2009-10-13
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Human PIK3C3 crystal structure
TO BE PUBLISHED
3IHL
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BU of 3ihl by Molmil
Human CTPS2 crystal structure
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CTP synthase 2, PHOSPHATE ION
Authors:Moche, M, Siponen, M.I, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kotenyova, T, Kotzsch, A, Kragh Nielsen, T, Nyman, T, Persson, C, Roos, A.K, Sagemark, J, Schueler, H, Schutz, P, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Nordlund, P, Structural Genomics Consortium (SGC)
Deposit date:2009-07-30
Release date:2009-10-13
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Human CTPS2 crystal structure
To be Published
3HKV
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BU of 3hkv by Molmil
Human poly(ADP-ribose) polymerase 10, catalytic fragment in complex with an inhibitor 3-aminobenzamide
Descriptor: 3-aminobenzamide, PHOSPHATE ION, Poly [ADP-ribose] polymerase 10, ...
Authors:Karlberg, T, Moche, M, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kotenyova, T, Kotzsch, A, Nielsen, T.K, Nordlund, P, Nyman, T, Persson, C, Roos, A.K, Sagemark, J, Schutz, P, Siponen, M.I, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Schuler, H, Structural Genomics Consortium (SGC)
Deposit date:2009-05-26
Release date:2009-06-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Human Poly(Adp-Ribose) Polymerase 10, Catalytic Fragment in Complex with an Inhibitor 3-Aminobenzamide
To be Published
3I35
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BU of 3i35 by Molmil
Human SH3 domain of protein LASP1
Descriptor: LIM and SH3 domain protein 1
Authors:Siponen, M.I, Roos, A.K, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kotenyova, T, Kotzsch, A, Kragh Nielsen, T, Moche, M, Nyman, T, Persson, C, Sagemark, J, Schueler, H, Schutz, P, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Nordlund, P, Structural Genomics Consortium (SGC)
Deposit date:2009-06-30
Release date:2009-09-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Human SH3 domain of protein LASP1
TO BE PUBLISHED
3IHJ
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BU of 3ihj by Molmil
Human alanine aminotransferase 2 in complex with PLP
Descriptor: Alanine aminotransferase 2, PHOSPHATE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Wisniewska, M, Siponen, M.I, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Karlberg, T, Kotenyova, T, Kotzsch, A, Moche, M, Nielsen, T.K, Nordlund, P, Nyman, T, Persson, C, Roos, A.K, Schutz, P, Svensson, L, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Schuler, H, Structural Genomics Consortium (SGC)
Deposit date:2009-07-30
Release date:2009-08-18
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Human glutamate pyruvate transaminase 2
To be Published
3KJD
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BU of 3kjd by Molmil
Human poly(ADP-ribose) polymerase 2, catalytic fragment in complex with an inhibitor ABT-888
Descriptor: (2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium, GLYCEROL, Poly [ADP-ribose] polymerase 2
Authors:Karlberg, T, Schutz, P, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kallas, A, Kotenyova, T, Kotzsch, A, Kraulis, P, Nielsen, T.K, Moche, M, Nordlund, P, Nyman, T, Persson, C, Roos, A.K, Siponen, M.I, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Schuler, H, Structural Genomics Consortium (SGC)
Deposit date:2009-11-03
Release date:2009-11-17
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888.
Biochemistry, 49, 2010
3KCZ
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BU of 3kcz by Molmil
Human poly(ADP-ribose) polymerase 2, catalytic fragment in complex with an inhibitor 3-aminobenzamide
Descriptor: 3-aminobenzamide, GLYCEROL, Poly [ADP-ribose] polymerase 2
Authors:Karlberg, T, Schutz, P, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kallas, A, Kotenyova, T, Kotzsch, A, Kraulis, P, Nielsen, T.K, Moche, M, Nordlund, P, Nyman, T, Persson, C, Roos, A.K, Siponen, M.I, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Schuler, H, Structural Genomics Consortium (SGC)
Deposit date:2009-10-22
Release date:2009-11-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888.
Biochemistry, 49, 2010
3KR8
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BU of 3kr8 by Molmil
Human tankyrase 2 - catalytic PARP domain in complex with an inhibitor XAV939
Descriptor: 2-[4-(trifluoromethyl)phenyl]-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-4-ol, GLYCEROL, SULFATE ION, ...
Authors:Karlberg, T, Schutz, P, Arrowsmith, C.H, Berglund, H, Bountra, C, Collins, R, Edwards, A.M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Johansson, A, Johansson, I, Kallas, A, Kotenyova, T, Kotzsch, A, Kraulis, P, Nielsen, T.K, Moche, M, Nordlund, P, Nyman, T, Persson, C, Siponen, M.I, Thorsell, A.G, Tresaugues, L, Van Den Berg, S, Weigelt, J, Welin, M, Wisniewska, M, Schuler, H, Structural Genomics Consortium (SGC)
Deposit date:2009-11-18
Release date:2009-12-15
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the interaction between tankyrase-2 and a potent Wnt-signaling inhibitor.
J.Med.Chem., 53, 2010
1WAQ
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BU of 1waq by Molmil
Crystal structure of human Growth and Differentiation Factor 5 (GDF-5)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, GROWTH/DIFFERENTIATION FACTOR 5
Authors:Mueller, T.D, Nickel, J, Sebald, W.
Deposit date:2004-10-27
Release date:2005-05-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:A Single Residue of Gdf-5 Defines Binding Specificity to Bmp Receptor Ib.
J.Mol.Biol., 349, 2005
3B5K
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BU of 3b5k by Molmil
Crystal structure of murine interleukin-5
Descriptor: Interleukin-5
Authors:Mueller, T.D, Patino, E.
Deposit date:2007-10-26
Release date:2008-11-04
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of murine interleukin-5
To be Published
2AQJ
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BU of 2aqj by Molmil
The structure of tryptophan 7-halogenase (PrnA) suggests a mechanism for regioselective chlorination
Descriptor: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, TRYPTOPHAN, ...
Authors:Dong, C, Flecks, S, Unversucht, S, Haupt, C, Van Pee, K.-H, Naismith, J.H, Scottish Structural Proteomics Facility (SSPF)
Deposit date:2005-08-18
Release date:2005-10-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination.
Science, 309, 2005
2AR8
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BU of 2ar8 by Molmil
The structure of tryptophan 7-halogenase (PrnA)suggests a mechanism for regioselective chlorination
Descriptor: 7-CHLOROTRYPTOPHAN, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Dong, C, Flecks, S, Unversucht, S, Haupt, C, Van Pee, K.H, Naismith, J.H, Scottish Structural Proteomics Facility (SSPF)
Deposit date:2005-08-19
Release date:2005-10-04
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination.
Science, 309, 2005
3QB4
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BU of 3qb4 by Molmil
Crystal structure of a TGF-beta ligand-receptor complex
Descriptor: Bone morphogenetic protein receptor type-1A, Growth/differentiation factor 5
Authors:Mueller, T.D, Nickel, J, Sebald, W.
Deposit date:2011-01-12
Release date:2012-03-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:GDF-5 can act as a context-dependent BMP-2 antagonist.
Bmc Biol., 13, 2015
2H64
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BU of 2h64 by Molmil
Crystal structure of a ternary ligand-receptor complex of BMP-2
Descriptor: Acvr2b protein, Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA
Authors:Mueller, T.D, Sebald, W, Weber, D.
Deposit date:2006-05-30
Release date:2007-04-10
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.
Bmc Struct.Biol., 7, 2007
2H62
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BU of 2h62 by Molmil
Crystal structure of a ternary ligand-receptor complex of BMP-2
Descriptor: Acvr2b protein, Bone morphogenetic protein 2, Bone morphogenetic protein receptor type IA
Authors:Mueller, T.D.
Deposit date:2006-05-30
Release date:2007-04-10
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor.
Bmc Struct.Biol., 7, 2007
3BK3
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BU of 3bk3 by Molmil
Crystal structure of the complex of BMP-2 and the first Von Willebrand domain type C of Crossveinless-2
Descriptor: Bone morphogenetic protein 2, Crossveinless 2
Authors:Mueller, T.D, Sebald, W, Zhang, J.-L.
Deposit date:2007-12-05
Release date:2008-05-27
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure analysis reveals how the Chordin family member crossveinless 2 blocks BMP-2 receptor binding
Dev.Cell, 14, 2008

 

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