3KJD

Human poly(ADP-ribose) polymerase 2, catalytic fragment in complex with an inhibitor ABT-888

Summary for 3KJD

• Entry DOI: 10.2210/pdb3kjd/pdb
• Related: 3KCZ
• Descriptor: Poly [ADP-ribose] polymerase 2, (2R)-2-(7-carbamoyl-1H-benzimidazol-2-yl)-2-methylpyrrolidinium, GLYCEROL, ... (4 entities in total)
• Functional Keywords: transferase, enzyme-inhibitor complex, catalytic fragment, structural genomics, structural genomics consortium, sgc, glycosyltransferase, nad, nucleus, dna-binding
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q9UGN5
• Total number of polymer chains: 2
• Total formula weight: 84328.62

Authors

Karlberg, T.,Schutz, P.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Kallas, A.,Kotenyova, T.,Kotzsch, A.,Kraulis, P.,Nielsen, T.K.,Moche, M.,Nordlund, P.,Nyman, T.,Persson, C.,Roos, A.K.,Siponen, M.I.,Thorsell, A.G.,Tresaugues, L.,Van Den Berg, S.,Weigelt, J.,Welin, M.,Wisniewska, M.,Schuler, H.,Structural Genomics Consortium (SGC) (deposition date: 2009-11-03, release date: 2009-11-17, Last modification date: 2023-11-01)

• Primary citation: Karlberg, T.,Hammarstrom, M.,Schutz, P.,Svensson, L.,Schuler, H.; Crystal structure of the catalytic domain of human PARP2 in complex with PARP inhibitor ABT-888.; Biochemistry, 49:1056-1058, 2010; PubMed: 20092359; DOI: 10.1021/bi902079y

Experimental method

X-RAY DIFFRACTION (1.95 Å)