3KJD
Human poly(ADP-ribose) polymerase 2, catalytic fragment in complex with an inhibitor ABT-888
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 78P A 1 |
| Chain | Residue |
| A | HOH161 |
| A | HOH183 |
| A | HIS428 |
| A | GLY429 |
| A | TYR462 |
| A | SER470 |
| A | TYR473 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 580 |
| Chain | Residue |
| A | ASN472 |
| A | CYS474 |
| A | PHE475 |
| A | ALA476 |
| A | PHE577 |
| A | ASP396 |
| A | ALA471 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 78P B 1 |
| Chain | Residue |
| B | HOH5 |
| B | HIS428 |
| B | GLY429 |
| B | TYR462 |
| B | SER470 |
| B | TYR473 |
| B | HOH584 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 2 |
| Chain | Residue |
| B | ASP396 |
| B | TYR397 |
| B | ALA471 |
| B | ASN472 |
| B | PHE475 |
| B | ALA476 |
| B | HOH659 |
| B | HOH710 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For poly [ADP-ribose] polymerase activity","evidences":[{"source":"PubMed","id":"26704974","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"30104678","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32028527","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"32028527","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6TX3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a26 |
| Chain | Residue | Details |
| A | TYR473 | |
| A | GLU558 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a26 |
| Chain | Residue | Details |
| B | TYR473 | |
| B | GLU558 |
