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3L0U
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THE CRYSTAL STRUCTURE OF UNMODIFIED TRNAPHE FROM ESCHERICHIA COLI
Descriptor:Unmodified tRNAPhe, MAGNESIUM ION, POTASSIUM ION
Authors:Byrne, R.T., Konevega, A.L., Rodnina, M.V., Antson, A.A.
Deposit date:2009-12-10
Release date:2010-03-16
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (3 Å)
Cite:The crystal structure of unmodified tRNAPhe from Escherichia coli
Nucleic Acids Res., 38, 2010
4W2F
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH AMICOUMACIN, MRNA AND THREE DEACYLATED TRNAS IN THE A, P AND E SITES
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Polikanov, Y.S., Osterman, I.A., Szal, T., Tashlitsky, V.N., Serebryakova, M.V., Kusochek, P., Bulkley, D., Malanicheva, I.A., Efimenko, T.A., Efremenkova, O.V., Konevega, A.L., Shaw, K.J., Bogdanov, A.A., Rodnina, M.V., Dontsova, O.A., Mankin, A.S., Steitz, T.A., Sergiev, P.V.
Deposit date:2014-09-12
Release date:2014-10-15
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Mol.Cell, 56, 2014
4W2G
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PACTAMYCIN (SOAKED), MRNA AND THREE DEACYLATED TRNAS IN THE A, P AND E SITES
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Polikanov, Y.S., Osterman, I.A., Szal, T., Tashlitsky, V.N., Serebryakova, M.V., Kusochek, P., Bulkley, D., Malanicheva, I.A., Efimenko, T.A., Efremenkova, O.V., Konevega, A.L., Shaw, K.J., Bogdanov, A.A., Rodnina, M.V., Dontsova, O.A., Mankin, A.S., Steitz, T.A., Sergiev, P.V.
Deposit date:2014-09-12
Release date:2014-10-15
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Mol.Cell, 56, 2014
4W2H
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PACTAMYCIN (CO-CRYSTALLIZED), MRNA AND DEACYLATED TRNA IN THE P SITE
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Polikanov, Y.S., Osterman, I.A., Szal, T., Tashlitsky, V.N., Serebryakova, M.V., Kusochek, P., Bulkley, D., Malanicheva, I.A., Efimenko, T.A., Efremenkova, O.V., Konevega, A.L., Shaw, K.J., Bogdanov, A.A., Rodnina, M.V., Dontsova, O.A., Mankin, A.S., Steitz, T.A., Sergiev, P.V.
Deposit date:2014-09-12
Release date:2014-10-15
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Mol.Cell, 56, 2014
4YCO
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E. COLI DIHYDROURIDINE SYNTHASE C (DUSC) IN COMPLEX WITH TRNAPHE
Descriptor:tRNA-dihydrouridine synthase C, tRNAphe, FLAVIN MONONUCLEOTIDE, ...
Authors:Byrne, R.T., Jenkins, H.T., Peters, D.T., Whelan, F., Stowell, J., Aziz, N., Kasatsky, P., Rodnina, M.V., Koonin, E.V., Konevega, A.L., Antson, A.A.
Deposit date:2015-02-20
Release date:2015-04-22
Last modified:2015-05-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Major reorientation of tRNA substrates defines specificity of dihydrouridine synthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
4YCP
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E. COLI DIHYDROURIDINE SYNTHASE C (DUSC) IN COMPLEX WITH TRNATRP
Descriptor:tRNA-dihydrouridine synthase C, tRNATrp, FLAVIN MONONUCLEOTIDE, ...
Authors:Byrne, R.T., Jenkins, H.T., Peters, D.T., Whelan, F., Stowell, J., Aziz, N., Kasatsky, P., Rodnina, M.V., Koonin, E.V., Konevega, A.L., Antson, A.A.
Deposit date:2015-02-20
Release date:2015-04-22
Last modified:2015-05-20
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Major reorientation of tRNA substrates defines specificity of dihydrouridine synthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
5AFI
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2.9A STRUCTURE OF E. COLI RIBOSOME-EF-TU COMPLEX BY CS-CORRECTED CRYO-EM
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Fischer, N., Neumann, P., Konevega, A.L., Bock, L.V., Ficner, R., Rodnina, M.V., Stark, H.
Deposit date:2015-01-22
Release date:2015-03-11
Last modified:2017-08-09
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure of the E. coli ribosome-EF-Tu complex at <3 A resolution by Cs-corrected cryo-EM.
NATURE, 520, 2015
5LZA
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STRUCTURE OF THE 70S RIBOSOME WITH SECIS-MRNA AND P-SITE TRNA (INITIAL COMPLEX, IC)
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Fischer, N., Neumann, P., Bock, L.V., Maracci, C., Wang, Z., Paleskava, A., Konevega, A.L., Schroeder, G.F., Grubmueller, H., Ficner, R., Rodnina, M.V., Stark, H.
Deposit date:2016-09-29
Release date:2016-11-23
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:The pathway to GTPase activation of elongation factor SelB on the ribosome.
Nature, 540, 2016
5LZB
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STRUCTURE OF SELB-SEC-TRNASEC BOUND TO THE 70S RIBOSOME IN THE INITIAL BINDING STATE (IB)
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Fischer, N., Neumann, P., Bock, L.V., Maracci, C., Wang, Z., Paleskava, A., Konevega, A.L., Schroeder, G.F., Grubmueller, H., Ficner, R., Rodnina, M.V., Stark, H.
Deposit date:2016-09-29
Release date:2016-11-23
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (5.3 Å)
Cite:The pathway to GTPase activation of elongation factor SelB on the ribosome.
Nature, 540, 2016
5LZC
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STRUCTURE OF SELB-SEC-TRNASEC BOUND TO THE 70S RIBOSOME IN THE CODON READING STATE (CR)
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Fischer, N., Neumann, P., Bock, L.V., Maracci, C., Wang, Z., Paleskava, A., Konevega, A.L., Schroeder, G.F., Grubmueller, H., Ficner, R., Rodnina, M.V., Stark, H.
Deposit date:2016-09-29
Release date:2016-11-23
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:The pathway to GTPase activation of elongation factor SelB on the ribosome.
Nature, 540, 2016
5LZD
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STRUCTURE OF SELB-SEC-TRNASEC BOUND TO THE 70S RIBOSOME IN THE GTPASE ACTIVATED STATE (GA)
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Fischer, N., Neumann, P., Bock, L.V., Maracci, C., Wang, Z., Paleskava, A., Konevega, A.L., Schroeder, G.F., Grubmueller, H., Ficner, R., Rodnina, M.V., Stark, H.
Deposit date:2016-09-29
Release date:2016-11-23
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:The pathway to GTPase activation of elongation factor SelB on the ribosome.
Nature, 540, 2016
5LZE
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STRUCTURE OF THE 70S RIBOSOME WITH SEC-TRNASEC IN THE CLASSICAL PRE-TRANSLOCATION STATE (C)
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Fischer, N., Neumann, P., Bock, L.V., Maracci, C., Wang, Z., Paleskava, A., Konevega, A.L., Schroeder, G.F., Grubmueller, H., Ficner, R., Rodnina, M.V., Stark, H.
Deposit date:2016-09-29
Release date:2016-11-23
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:The pathway to GTPase activation of elongation factor SelB on the ribosome.
Nature, 540, 2016
5LZF
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STRUCTURE OF THE 70S RIBOSOME WITH FMETSEC-TRNASEC IN THE HYBRID PRE-TRANSLOCATION STATE (H)
Descriptor:16S ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Fischer, N., Neumann, P., Bock, L.V., Maracci, C., Wang, Z., Paleskava, A., Konevega, A.L., Schroeder, G.F., Grubmueller, H., Ficner, R., Rodnina, M.V., Stark, H.
Deposit date:2016-09-29
Release date:2016-11-23
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:The pathway to GTPase activation of elongation factor SelB on the ribosome.
Nature, 540, 2016
5VP2
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH MADUMYCIN II AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.8A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Osterman, I.A., Khabibullina, N.F., Komarova, E.S., Kasatsky, P., Kartsev, V.G., Bogdanov, A.A., Dontsova, O.A., Konevega, A.L., Sergiev, P.V., Polikanov, Y.S.
Deposit date:2017-05-04
Release date:2017-06-28
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state.
Nucleic Acids Res., 45, 2017
5W4K
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH KLEBSAZOLICIN AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.7A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Metelev, M., Osterman, I.A., Ghilarov, D., Khabibullina, N.F., Yakimov, A., Shabalin, K., Utkina, I., Travin, D.Y., Komarova, E.S., Serebryakova, M., Artamonova, T., Khodorkovskii, M., Konevega, A.L., Sergiev, P.V., Severinov, K., Polikanov, Y.S.
Deposit date:2017-06-12
Release date:2017-08-30
Last modified:2018-06-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel.
Nat. Chem. Biol., 13, 2017
6CFJ
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH HISTIDYL-CAM AND BOUND TO MRNA AND A-, P-, AND E-SITE TRNAS AT 2.8A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Tereshchenkov, A.G., Dobosz-Bartoszek, M., Osterman, I.A., Marks, J., Sergeeva, V.A., Kasatsky, P., Komarova, E.S., Stavrianidi, A.N., Rodin, I.A., Konevega, A.L., Sergiev, P.V., Sumbatyan, N.V., Mankin, A.S., Bogdanov, A.A., Polikanov, Y.S.
Deposit date:2018-02-15
Release date:2018-03-07
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Binding and Action of Amino Acid Analogs of Chloramphenicol upon the Bacterial Ribosome.
J. Mol. Biol., 430, 2018
6CFK
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH D-HISTIDYL-CAM AND BOUND TO PROTEIN Y (YFIA) AT 2.7A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Tereshchenkov, A.G., Dobosz-Bartoszek, M., Osterman, I.A., Marks, J., Sergeeva, V.A., Kasatsky, P., Komarova, E.S., Stavrianidi, A.N., Rodin, I.A., Konevega, A.L., Sergiev, P.V., Sumbatyan, N.V., Mankin, A.S., Bogdanov, A.A., Polikanov, Y.S.
Deposit date:2018-02-15
Release date:2018-03-07
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Binding and Action of Amino Acid Analogs of Chloramphenicol upon the Bacterial Ribosome.
J. Mol. Biol., 430, 2018
6CFL
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH LYSYL-CAM AND BOUND TO PROTEIN Y (YFIA) AT 2.6A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Tereshchenkov, A.G., Dobosz-Bartoszek, M., Osterman, I.A., Marks, J., Sergeeva, V.A., Kasatsky, P., Komarova, E.S., Stavrianidi, A.N., Rodin, I.A., Konevega, A.L., Sergiev, P.V., Sumbatyan, N.V., Mankin, A.S., Bogdanov, A.A., Polikanov, Y.S.
Deposit date:2018-02-15
Release date:2018-03-07
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Binding and Action of Amino Acid Analogs of Chloramphenicol upon the Bacterial Ribosome.
J. Mol. Biol., 430, 2018
4BF9
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CRYSTAL STRUCTURE OF E. COLI DIHYDROURIDINE SYNTHASE C (DUSC) (SELENOMETHIONINE DERIVATIVE)
Descriptor:TRNA-DIHYDROURIDINE SYNTHASE C, FLAVIN MONONUCLEOTIDE
Authors:Byrne, R.T., Whelan, F., Konevega, A., Aziz, N., Rodnina, M., Antson, A.A.
Deposit date:2013-03-16
Release date:2013-11-06
Last modified:2015-05-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Major Reorientation of tRNA Substrates Defines Specificity of Dihydrouridine Synthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
4BFA
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CRYSTAL STRUCTURE OF E. COLI DIHYDROURIDINE SYNTHASE C (DUSC)
Descriptor:TRNA-DIHYDROURIDINE SYNTHASE C, FLAVIN MONONUCLEOTIDE, 1,2-ETHANEDIOL, ...
Authors:Byrne, R.T., Whelan, F., Konevega, A., Aziz, N., Rodnina, M., Antson, A.A.
Deposit date:2013-03-16
Release date:2013-11-06
Last modified:2015-05-27
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Major Reorientation of tRNA Substrates Defines Specificity of Dihydrouridine Synthases.
Proc.Natl.Acad.Sci.USA, 112, 2015
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