7MD7

Crystal structure of the Thermus thermophilus 70S ribosome in complex with triphenylphosphonium analog of chloramphenicol CAM-C4-TPP and protein Y (YfiA) at 2.80A resolution

This is a non-PDB format compatible entry.

Summary for 7MD7

• Entry DOI: 10.2210/pdb7md7/pdb
• Descriptor: 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (60 entities in total)
• Functional Keywords: chloramphenicol, antibiotic, 70s ribosome, translation inhibitor, peptidyl transferase center, nascent peptide exit tunnel, ribosome
• Biological source: Escherichia coli (strain K12); More
• Total number of polymer chains: 106
• Total formula weight: 4428454.05

Authors

Chen, C.-W.,Pavlova, J.A.,Lukianov, D.A.,Tereshchenkov, A.G.,Makarov, G.I.,Khairullina, Z.Z.,Tashlitsky, V.N.,Paleskava, A.,Konevega, A.L.,Bogdanov, A.A.,Osterman, I.A.,Sumbatyan, N.V.,Polikanov, Y.S. (deposition date: 2021-04-03, release date: 2021-04-21, Last modification date: 2023-11-15)

• Primary citation: Chen, C.W.,Pavlova, J.A.,Lukianov, D.A.,Tereshchenkov, A.G.,Makarov, G.I.,Khairullina, Z.Z.,Tashlitsky, V.N.,Paleskava, A.,Konevega, A.L.,Bogdanov, A.A.,Osterman, I.A.,Sumbatyan, N.V.,Polikanov, Y.S.; Binding and Action of Triphenylphosphonium Analog of Chloramphenicol upon the Bacterial Ribosome.; Antibiotics, 10:-, 2021; PubMed: 33916420; DOI: 10.3390/antibiotics10040390

Experimental method

X-RAY DIFFRACTION (2.8 Å)