Author results

4F4B
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STRUCTURE OF OSH4 WITH A CHOLESTEROL ANALOG
Descriptor:Protein KES1, (3beta,9beta,25R)-3-hydroxy-26-iodocholest-5-ene-16,22-dione
Authors:Koag, M.C., Monzingo, A.F., Cheun, Y., Lee, S.
Deposit date:2012-05-10
Release date:2013-05-15
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Synthesis and structure of 16,22-diketocholesterol bound to oxysterol-binding protein Osh4.
Steroids, 78, 2013
4FES
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STRUCTURE OF OSH4 IN COMPLEX WITH CHOLESTEROL ANALOGS
Descriptor:Protein KES1, (3S,8S,9S,10R,13S,14S,17R)-3-hydroxy-10,13-dimethyl-17-[(2S,6S)-6-methyl-3-oxooctan-2-yl]-1,2,3,4,7,8,9,10,11,12,13,14,15,17-tetradecahydro-16H-cyclopenta[a]phenanthren-16-one
Authors:Koag, M.C., Monzingo, A.F., Cheun, Y., Lee, S.
Deposit date:2012-05-30
Release date:2013-06-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Synthesis and structure of 16,22-diketocholesterol bound to oxysterol-binding protein Osh4.
Steroids, 78, 2013
4JCH
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OSH4 BOUND TO AN ELECTROPHILIC OXYSTEROL
Descriptor:Protein KES1, (3beta,9beta,22R,25R)-3-hydroxyfurost-5-en-27-yl propanoate
Authors:Koag, M.C., Kou, Y.I., Monzingo, A.F., Lee, S.
Deposit date:2013-02-21
Release date:2014-03-26
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of OSH4 bound to an electrophilic oxysterol
To be Published
4M2Y
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STRUCTURE OF HUMAN DNA POLYMERASE BETA COMPLEXED WITH 8-BRG AS THE TEMPLATE BASE IN A 1-NUCLEOTIDE GAPPED DNA
Descriptor:DNA polymerase beta, template DNA strand, up-primer, ...
Authors:Koag, M.C., Min, K., Monzingo, A.F., Lee, S.
Deposit date:2013-08-05
Release date:2014-01-22
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structural basis for promutagenicity of 8-halogenated Guanine.
J.Biol.Chem., 289, 2014
4M47
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STRUCTURE OF HUMAN DNA POLYMERASE COMPLEXED WITH 8-BRG IN THE TEMPLATE BASE PAIRED WITH INCOMING NON-HYDROLYZABLE GTP
Descriptor:DNA polymerase beta, a synthetic template, a synthetic upstream primer, ...
Authors:Koag, M.C., Min, K., Monzingo, A.F., Lee, S.
Deposit date:2013-08-06
Release date:2014-01-22
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structural basis for promutagenicity of 8-halogenated Guanine.
J.Biol.Chem., 289, 2014
4MF2
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STRUCTURE OF HUMAN DNA POLYMERASE BETA COMPLEXED WITH O6MG AS THE TEMPLATE BASE IN A 1-NUCLEOTIDE GAPPED DNA
Descriptor:DNA polymerase beta, synthetic template DNA, synthetic upstream primer, ...
Authors:Koag, M.C., Min, K., Monzingo, A.F., Lee, S.
Deposit date:2013-08-27
Release date:2014-04-16
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase beta.
J.Am.Chem.Soc., 136, 2014
4MF8
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STRUCTURE OF HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA CONTAINING A MISMATCHED TEMPLATE O6MG AND INCOMING CTP
Descriptor:DNA polymerase beta, template, primer, ...
Authors:Koag, M.C., Min, K., Monzingo, A.F., Lee, S.
Deposit date:2013-08-27
Release date:2014-08-27
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structures of human DNA polymerase beta inserting bases opposite templating O6MG
To be Published
4MFA
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STRUCTURE OF HUMAN DNA POLYMERASE BETA COMPLEXED WITH NICKED DNA CONTAINING A MISMATCHED TEMPLATE O6MG AND INCOMING TTP
Descriptor:DNA polymerase beta, template, up primer, ...
Authors:Koag, M.C., Min, K., Monzingo, A.F., Lee, S.
Deposit date:2013-08-27
Release date:2014-08-27
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structures of human DNA polymerase beta inserting bases opposite templating O6MG
To be Published
4MFC
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STRUCTURE OF HUMAN DNA POLYMERASE BETA COMPLEXED WITH O6MG IN THE TEMPLATE BASE PAIRED WITH INCOMING NON-HYDROLYZABLE CTP
Descriptor:DNA polymerase beta, template, up primer, ...
Authors:Koag, M.C., Min, K., Monzingo, A.F., Lee, S.
Deposit date:2013-08-27
Release date:2014-04-16
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase beta.
J.Am.Chem.Soc., 136, 2014
4MFF
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STRUCTURE OF HUMAN DNA POLYMERASE BETA COMPLEXED WITH O6MG IN THE TEMPLATE BASE PAIRED WITH INCOMING NON-HYDROLYZABLE TTP
Descriptor:DNA polymerase beta, template, up primer, ...
Authors:Koag, M.C., Min, K., Monzingo, A.F., Lee, S.
Deposit date:2013-08-27
Release date:2014-04-16
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Metal-dependent conformational activation explains highly promutagenic replication across O6-methylguanine by human DNA polymerase beta.
J.Am.Chem.Soc., 136, 2014
4O5C
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STRUCTURE OF HUMAN DNA POLYMERASE COMPLEXED WITH N7-MG AS THE TEMPLATE BASE IN A 1-NUCLEOTIDE GAPPED DNA
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*(FMG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ...
Authors:Koag, M.C., Lee, S.
Deposit date:2013-12-19
Release date:2014-07-02
Last modified:2015-05-27
Method:X-RAY DIFFRACTION (2.363 Å)
Cite:Transition-state destabilization reveals how human DNA polymerase beta proceeds across the chemically unstable lesion N7-methylguanine.
Nucleic Acids Res., 42, 2014
4O5E
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STRUCTURE OF HUMAN DNA POLYMERASE COMPLEXED WITH N7MG IN THE TEMPLATE BASE PAIRED WITH INCOMING NON-HYDROLYZABLE TTP
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*(FMG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ...
Authors:Koag, M.C., Lee, S.
Deposit date:2013-12-19
Release date:2014-07-02
Last modified:2015-05-27
Method:X-RAY DIFFRACTION (2.532 Å)
Cite:Transition-state destabilization reveals how human DNA polymerase beta proceeds across the chemically unstable lesion N7-methylguanine.
Nucleic Acids Res., 42, 2014
4O5K
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STRUCTURE OF HUMAN DNA POLYMERASE COMPLEXED WITH N7MG IN THE TEMPLATE BASE PAIRED WITH INCOMING NON-HYDROLYZABLE CTP
Descriptor:DNA (5'-D(*CP*CP*GP*AP*CP*(FMG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ...
Authors:Koag, M.C., Lee, S.
Deposit date:2013-12-19
Release date:2014-07-02
Last modified:2015-05-27
Method:X-RAY DIFFRACTION (2.058 Å)
Cite:Transition-state destabilization reveals how human DNA polymerase beta proceeds across the chemically unstable lesion N7-methylguanine.
Nucleic Acids Res., 42, 2014
4PGQ
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STRUCTURE OF HUMAN DNA POLYMERASE BETA COMPLEXED WITH G IN THE TEMPLATE BASE PAIRED WITH INCOMING NON-HYDROLYZABLE TTP
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*GP*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ...
Authors:Koag, M.C., Lee, S.
Deposit date:2014-05-02
Release date:2014-10-01
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase beta.
Nucleic Acids Res., 42, 2015
4PGX
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STRUCTURE OF HUMAN DNA POLYMERASE BETA COMPLEXED WITH G IN THE TEMPLATE BASE PAIRED WITH INCOMING NON-HYDROLYZABLE TTP AND MANGANESE
Descriptor:DNA (5'-D(*CP*CP*GP*AP*CP*GP*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ...
Authors:Koag, M.C., Lee, S.
Deposit date:2014-05-03
Release date:2014-09-24
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.077 Å)
Cite:The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase beta.
Nucleic Acids Res., 42, 2015
4PGY
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STRUCTURE OF HUMAN DNA POLYMERASE BETA COMPLEXED WITH A NICKED DNA CONTAINING A GT AT N-1 POSITION AND GC AT N POSITION
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), ...
Authors:Koag, M.C., Lee, S.
Deposit date:2014-05-03
Release date:2015-05-06
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:The spontaneous base substitution mechanisms of human DNA polymerase beta
To Be Published
4PH5
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STRUCTURE OF HUMAN DNA POLYMERASE BETA COMPLEXED WITH A NICKED DNA CONTAINING A AC AT N-1 POSITION AND GC AT N POSITION
Descriptor:DNA (5'-D(*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ...
Authors:Koag, M.C., Lee, S.
Deposit date:2014-05-04
Release date:2015-05-06
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The spontaneous base substitution mechanisms of human DNA polymerase beta
To Be Published
4PHA
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STRUCTURE OF HUMAN DNA POLYMERASE BETA COMPLEXED WITH A IN THE TEMPLATE BASE PAIRED WITH INCOMING NON-HYDROLYZABLE CTP
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*AP*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ...
Authors:Koag, M.C., Lee, S.
Deposit date:2014-05-05
Release date:2014-09-24
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase beta.
Nucleic Acids Res., 42, 2015
4PHD
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STRUCTURE OF HUMAN DNA POLYMERASE BETA COMPLEXED WITH A IN THE TEMPLATE BASE PAIRED WITH INCOMING NON-HYDROLYZABLE CTP AND MANGANESE
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*AP*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ...
Authors:Koag, M.C., Lee, S.
Deposit date:2014-05-06
Release date:2014-09-24
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase beta.
Nucleic Acids Res., 42, 2015
4PHE
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STRUCTURE OF HUMAN DNA POLYMERASE BETA COMPLEXED WITH T IN THE TEMPLATE BASE PAIRED WITH INCOMING NON-HYDROLYZABLE GTP
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*TP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ...
Authors:Koag, M.C., Lee, S.
Deposit date:2014-05-06
Release date:2015-05-06
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The spontaneous base substitution mechanisms of human DNA polymerase beta
To Be Published
4PHP
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STRUCTURE OF HUMAN DNA POLYMERASE BETA COMPLEXED WITH T IN THE TEMPLATE BASE PAIRED WITH INCOMING NON-HYDROLYZABLE GTP AND MANGANESE
Descriptor:DNA (5'-D(*CP*CP*GP*AP*CP*TP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ...
Authors:Koag, M.C., Lee, S.
Deposit date:2014-05-06
Release date:2015-05-06
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The spontaneous base substitution mechanisms of human DNA polymerase beta
To Be Published
4TUP
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STRUCTURE OF HUMAN DNA POLYMERASE BETA COMPLEXED WITH GG AS THE TEMPLATE (GG0B) IN A 1-NUCLEOTIDE GAPPED DNA
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*CP*AP*CP*GP*GP*CP*CP*CP*AP*TP*CP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*GP*AP*TP*GP*GP*GP*C)-3'), ...
Authors:Koag, M.C., Lee, S.
Deposit date:2014-06-24
Release date:2014-10-01
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for the Inefficient Nucleotide Incorporation Opposite Cisplatin-DNA Lesion by Human DNA Polymerase beta.
J.Biol.Chem., 289, 2014
4TUQ
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HUMAN DNA POLYMERASE BETA INSERTING DCMPNPP OPPOSITE GG TEMPLATE (GG0B).
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*CP*AP*CP*GP*GP*CP*CP*CP*AP*TP*CP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*GP*AP*TP*GP*GP*GP*C)-3'), ...
Authors:Koag, M.C., Lee, S.
Deposit date:2014-06-24
Release date:2014-10-01
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.367 Å)
Cite:Structural Basis for the Inefficient Nucleotide Incorporation Opposite Cisplatin-DNA Lesion by Human DNA Polymerase beta.
J.Biol.Chem., 289, 2014
4TUR
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HUMAN DNA POLYMERASE BETA INSERTING DCMPNPP OPPOSITE THE 5'G OF CISPLATIN CROSSLINKED GS (PT-GG2)
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*CP*AP*CP*GP*GP*CP*CP*CP*AP*TP*CP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*GP*AP*TP*GP*GP*GP*C)-3'), ...
Authors:Koag, M.C., Lee, S.
Deposit date:2014-06-24
Release date:2014-10-01
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.169 Å)
Cite:Structural Basis for the Inefficient Nucleotide Incorporation Opposite Cisplatin-DNA Lesion by Human DNA Polymerase beta.
J.Biol.Chem., 289, 2014
4TUS
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HUMAN DNA POLYMERASE BETA INSERTING DCMPNPP OPPOSITE THE 5'G OF CISPLATIN CROSSLINKED GS (PT-GG2) WITH MANGANESE IN THE ACTIVE SITE.
Descriptor:DNA polymerase beta, DNA (5'-D(*CP*CP*CP*AP*CP*GP*GP*CP*CP*CP*AP*TP*CP*AP*CP*C)-3'), DNA (5'-D(P*GP*GP*TP*GP*AP*TP*GP*GP*GP*C)-3'), ...
Authors:Koag, M.C., Lee, S.
Deposit date:2014-06-24
Release date:2014-10-01
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Structural Basis for the Inefficient Nucleotide Incorporation Opposite Cisplatin-DNA Lesion by Human DNA Polymerase beta.
J.Biol.Chem., 289, 2014
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