Author results

6HUE
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PARKINS65N
Descriptor:E3 ubiquitin-protein ligase parkin, ZINC ION, SULFATE ION, ...
Authors:McWilliams, T.G., Barini, E., Pohjolan-Pirhonen, R., Brooks, S.P., Singh, F., Burel, S., Balk, K., Kumar, A., Montava-Garriga, L., Prescott, A.R., Hassoun, S.M., Mouton-Liger, F., Ball, G., Hills, R., Knebel, A., Ulusoy, A., Di Monte, D.A., Tamjar, J., Antico, O., Fears, K., Smith, L., Brambilla, R., Palin, E., Valori, M., Eerola-Rautio, J., Tienari, P., Corti, O., Dunnett, S.B., Ganley, I.G., Suomalainen, A., Muqit, M.M.K.
Deposit date:2018-10-07
Release date:2018-10-17
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Phosphorylation of Parkin at serine 65 is essential for its activationin vivo.
Open Biol, 8, 2018
5C1Z
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PARKIN (UBLR0RBR)
Descriptor:E3 ubiquitin-protein ligase parkin, ZINC ION, SULFATE ION, ...
Authors:kumar, A., Aguirre, J.D., Condos, T.E.C., Martinez-Torres, R.J., Chaugule, V.K., Toth, R., Sundaramoorthy, R., Mercier, P., Knebel, A., Spratt, D.E., Barber, K.R., Shaw, G.S., Walden, H.
Deposit date:2015-06-15
Release date:2015-07-29
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
Embo J., 34, 2015
5C23
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PARKIN (S65DUBLR0RBR)
Descriptor:E3 ubiquitin-protein ligase parkin, ZINC ION, GLYCEROL, ...
Authors:Kumar, A., Aguirre, J.D., Condos, T.E.C., Martinez-Torres, R.J., Chaugule, V.K., Toth, R., Sundaramoorthy, R., Mercier, P., Knebel, A., Spratt, D.E., Barber, K.R., Shaw, G.S., Walden, H.
Deposit date:2015-06-15
Release date:2015-07-29
Last modified:2015-10-28
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Disruption of the autoinhibited state primes the E3 ligase parkin for activation and catalysis.
Embo J., 34, 2015
5N2W
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WT-PARKIN AND PUB COMPLEX
Descriptor:E3 ubiquitin-protein ligase parkin,E3 ubiquitin-protein ligase parkin, Polyubiquitin-B, ZINC ION, ...
Authors:Kumar, A., Chaugule, V.K., Johnson, C., Toth, R., Sundaramoorthy, R., Knebel, A., Walden, H.
Deposit date:2017-02-08
Release date:2017-04-19
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
Nat. Struct. Mol. Biol., 24, 2017
5N38
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S65DPARKIN AND PUB COMPLEX
Descriptor:E3 ubiquitin-protein ligase parkin,E3 ubiquitin-protein ligase parkin, Polyubiquitin-B, DI(HYDROXYETHYL)ETHER, ...
Authors:Kumar, A., Chaugule, V.K., Johnson, C., Toth, R., Sundaramoorthy, R., Knebel, A., Walden, H.
Deposit date:2017-02-08
Release date:2017-04-19
Last modified:2018-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Parkin-phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity.
Nat. Struct. Mol. Biol., 24, 2017
4WIP
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DIX DOMAIN OF HUMAN DVL2
Descriptor:Segment polarity protein dishevelled homolog DVL-2, PENTAETHYLENE GLYCOL
Authors:Fiedler, M., Bienz, M., Madrzak, J., Chin, J.W.
Deposit date:2014-09-26
Release date:2015-05-13
Method:X-RAY DIFFRACTION (2.691 Å)
Cite:Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerization.
Nat Commun, 6, 2015
5K9P
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SER20 PHOSPHORYLATED UBIQUITIN
Descriptor:Polyubiquitin-B
Authors:Huguenin-Dezot, N., Chin, J.W.
Deposit date:2016-06-01
Release date:2016-07-20
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity.
Cell Rep, 16, 2016
5MN9
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CRYSTAL STRUCTURE OF MINDY-1 TMIU IN COMPLEX WITH K48-DIUB
Descriptor:Ubiquitin-40S ribosomal protein S27a, Ubiquitin carboxyl-terminal hydrolase MINDY-1
Authors:Kristariyanto, Y.A., Abdul Rehman, S.A., Kulathu, Y.
Deposit date:2016-12-13
Release date:2017-01-25
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:A single MIU motif of MINDY-1 recognizes K48-linked polyubiquitin chains.
EMBO Rep., 18, 2017
5O6C
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CRYSTAL STRUCTURE OF A THREONINE-SELECTIVE RCR E3 LIGASE
Descriptor:E3 ubiquitin-protein ligase MYCBP2, ZINC ION
Authors:Pao, K.-C., Rafie, K.Z., van Aalten, D., Virdee, S.
Deposit date:2017-06-06
Release date:2018-04-18
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.
Nature, 556, 2018
6N13
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UBCH7-UB COMPLEX WITH R0RBR PARKIN AND PHOSPHOUBIQUITIN
Descriptor:E3 ubiquitin-protein ligase parkin, ubiquitin, Ubiquitin-conjugating enzyme E2 L3, ...
Authors:Condos, T.E.C., Dunkerley, K.M., Freeman, E.A., Barber, K.R., Aguirre, J.D., Chaugule, V.K., Xiao, Y., Konermann, L., Walden, H., Shaw, G.S.
Deposit date:2018-11-08
Release date:2018-11-28
Last modified:2018-12-12
Method:SOLUTION NMR
Cite:Synergistic recruitment of UbcH7~Ub and phosphorylated Ubl domain triggers parkin activation.
EMBO J., 37, 2018