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2FLS
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CRYSTAL STRUCTURE OF HUMAN GLUTAREDOXIN 2 COMPLEXED WITH GLUTATHIONE
分子名称:Glutaredoxin-2, GLUTATHIONE
著者Johansson, C., Smee, C., Kavanagh, K.L., Debreczeni, J., von Delft, F., Gileadi, O., Arrowsmith, C., Weigelt, J., Edwards, A., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
登録日2006-01-06
公開日2006-01-24
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Crystal structure of Human Glutaredoxin 2 complexed with glutathione
To be Published
2GS3
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CRYSTAL STRUCTURE OF THE SELENOCYSTEINE TO GLYCINE MUTANT OF HUMAN GLUTATHIONE PEROXIDASE 4(GPX4)
分子名称:Phospholipid hydroperoxide glutathione peroxidase, CHLORIDE ION
著者Johansson, C., Kavanagh, K.L., Rojkova, A., Gileadi, O., von Delft, F., Arrowsmith, C., Weigelt, J., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
登録日2006-04-25
公開日2006-05-09
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 4(GPX4)
To be Published
2HT9
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THE STRUCTURE OF DIMERIC HUMAN GLUTAREDOXIN 2
分子名称:Glutaredoxin-2, 12-mer peptide, GLUTATHIONE, ...
著者Johansson, C., Smee, C., Kavanagh, K.L., Debreczeni, J., von Delft, F., Gileadi, O., Arrowsmith, C., Weigelt, J., Edwards, A., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
登録日2006-07-25
公開日2006-08-29
最終更新日2012-12-05
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria
J.Biol.Chem., 282, 2007
6I8B
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CRYSTAL STRUCTURE OF SPINDLIN1 IN COMPLEX WITH THE INHIBITOR VINSPININ
分子名称:Spindlin-1, 2-[4-[2-[[2-[3-[2-azanyl-5-(cyclopropylmethoxy)-3,3-dimethyl-indol-6-yl]oxypropyl]-1,3-dihydroisoindol-5-yl]oxy]ethyl]-1,2,3-triazol-1-yl]-1-[4-(2-pyrrolidin-1-ylethyl)piperidin-1-yl]ethanone, DIMETHYL SULFOXIDE, ...
著者Johansson, C., Fagan, V., Brennan, P.E., Sorrell, F.J., Krojer, T., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U.C.T.
登録日2018-11-19
公開日2018-12-05
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Crystal structure of Spindlin1 in complex with the inhibitor VinSpinIn
To Be Published
6I8L
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CRYSTAL STRUCTURE OF SPINDLIN1 IN COMPLEX WITH THE INHIBITOR TD001851A
分子名称:Spindlin-1, (4S)-2-METHYL-2,4-PENTANEDIOL, (4R)-2-METHYLPENTANE-2,4-DIOL, ...
著者Johansson, C., Fagan, V., Brennan, P.E., Sorrell, F.J., Krojer, T., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U.C.T.
登録日2018-11-20
公開日2018-12-05
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Crystal structure of Spindlin1 in complex with the inhibitor TD001851a
To Be Published
1BOC
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THE SOLUTION STRUCTURES OF MUTANT CALBINDIN D9K'S, AS DETERMINED BY NMR, SHOW THAT THE CALCIUM BINDING SITE CAN ADOPT DIFFERENT FOLDS
分子名称:CALBINDIN D9K
著者Johansson, C., Ullner, M., Drakenberg, T.
登録日1993-04-23
公開日1993-10-31
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献The solution structures of mutant calbindin D9k's, as determined by NMR, show that the calcium-binding site can adopt different folds.
Biochemistry, 32, 1993
1BOD
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THE SOLUTION STRUCTURES OF MUTANT CALBINDIN D9K'S, AS DETERMINED BY NMR, SHOW THAT THE CALCIUM BINDING SITE CAN ADOPT DIFFERENT FOLDS
分子名称:CALBINDIN D9K
著者Johansson, C., Ullner, M., Drakenberg, T.
登録日1993-04-23
公開日1993-10-31
最終更新日2013-05-01
実験手法SOLUTION NMR
主引用文献The solution structures of mutant calbindin D9k's, as determined by NMR, show that the calcium-binding site can adopt different folds.
Biochemistry, 32, 1993
1RKJ
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SOLUTION STRUCTURE OF THE COMPLEX FORMED BY THE TWO N-TERMINAL RNA-BINDING DOMAINS OF NUCLEOLIN AND A PRE-RRNA TARGET
分子名称:5'-R(*GP*GP*AP*UP*GP*CP*CP*UP*CP*CP*CP*GP*AP*GP*UP*GP*CP*AP*UP*CP*C)-3', Nucleolin
著者Johansson, C., Finger, L.D., Trantirek, L., Mueller, T.D., Kim, S., Laird-Offringa, I.A., Feigon, J.
登録日2003-11-21
公開日2004-04-27
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Solution structure of the complex formed by the two N-terminal RNA-binding domains of nucleolin and a pre-rRNA target.
J.Mol.Biol., 337, 2004
4UF0
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CRYSTAL STRUCTURE OF JMJC DOMAIN OF HUMAN HISTONE DEMETHYLASE UTY IN COMPLEX WITH EPITHERAPUETIC COMPOUND 2-(((2-((2-(DIMETHYLAMINO)ETHYL) (ETHYL)AMINO)-2-OXOETHYL)AMINO)METHYL)ISONICOTINIC ACID.
分子名称:HISTONE DEMETHYLASE UTY, FE (II) ION, 2-{[(2-{[(E)-2-(dimethylamino)ethenyl](ethyl)amino}-2-oxoethyl)amino]methyl}pyridine-4-carboxylic acid, ...
著者Srikannathasan, V., Johansson, C., Gileadi, C., Tobias, K., Kopec, J., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U.
登録日2014-12-22
公開日2015-01-14
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
5A1F
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PLU1 IN COMPLEX WITH N-OXALYLGLYCINE.
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, N-OXALYLGLYCINE, ...
著者Srikannathasan, V., Johansson, C., Strain-Damerell, C., Gileadi, C., Szykowska, A., Kupinska, K., Kopec, J., Krojer, T., Steuber, H., von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.
登録日2015-04-29
公開日2015-05-06
最終更新日2016-06-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
5A3P
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN PLU1 (JARID1B).
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, MANGANESE (II) ION, ...
著者Nowak, R., Srikannathasan, V., Johansson, C., Gileadi, C., Tallant, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.
登録日2015-06-02
公開日2015-06-10
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.008 Å)
主引用文献Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
5A3T
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CRYSTAL STRUCTURE OF HUMAN PLU-1 (JARID1B) IN COMPLEX WITH KDM5-C49 (2-(((2-((2-(DIMETHYLAMINO)ETHYL)(ETHYL)AMINO)-2-OXOETHYL)AMINO)METHYL) ISONICOTINIC ACID).
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Srikannathasan, V., Johansson, C., Gileadi, C., Kopec, J., Strain-Damerell, C., Kupinska, K., BurgessBrown, N.A., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.
登録日2015-06-02
公開日2015-06-17
最終更新日2016-06-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
5A3W
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CRYSTAL STRUCTURE OF HUMAN PLU-1 (JARID1B) IN COMPLEX WITH PYRIDINE-2, 6-DICARBOXYLIC ACID (PDCA)
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, SODIUM ION, ...
著者Srikannathasan, V., Johansson, C., Gileadi, C., Kopec, J., Strain-Damerell, C., Kupinska, K., Burgess-Brown, N.A., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.
登録日2015-06-03
公開日2015-06-17
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
5FPU
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CRYSTAL STRUCTURE OF HUMAN JARID1B IN COMPLEX WITH GSKJ1
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, 3-[[2-pyridin-2-yl-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino]propanoic acid, ...
著者Srikannathasan, V., Nowak, R., Johansson, C., Gileadi, C., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U.
登録日2015-12-03
公開日2016-01-13
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.24 Å)
主引用文献Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
5FUN
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CRYSTAL STRUCTURE OF HUMAN JARID1B IN COMPLEX WITH GSK467
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, 2-[(1-benzyl-1H-pyrazol-4-yl)oxy]pyrido[3,4-d]pyrimidin-4(3H)-one, ...
著者Srikannathasan, V., Johansson, C., Gileadi, C., Kopec, J., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Brennan, P., Oppermann, U.
登録日2016-01-28
公開日2016-04-13
最終更新日2016-06-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
5FUP
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CRYSTAL STRUCTURE OF HUMAN JARID1B IN COMPLEX WITH 2-OXOGLUTARATE.
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, MANGANESE (II) ION, ...
著者Nowak, R., Srikannathasan, V., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., Talon, R., von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.
登録日2016-01-28
公開日2016-03-23
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
5FV3
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CRYSTAL STRUCTURE OF HUMAN JARID1B CONSTRUCT C2 IN COMPLEX WITH N- OXALYLGLYCINE.
分子名称:LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, DIMETHYL SULFOXIDE, ...
著者Nowak, R., Srikannathasan, V., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., Talon, R., von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Oppermann, U.
登録日2016-02-02
公開日2016-02-17
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
5FWJ
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CRYSTAL STRUCTURE OF HUMAN JARID1C IN COMPLEX WITH KDM5-C49
分子名称:HISTONE DEMETHYLASE JARID1C, MAGNESIUM ION, ZINC ION, ...
著者Srikannathasan, V., Szykowska, A., Strain-Damerell, C., Kopec, J., Nowak, R., Gileadi, C., Johansson, C., Kupinska, K., Burgess-Brown, N.A., Shrestha, L., Dong, W., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Huber, K., Oppermann, U.
登録日2016-02-17
公開日2016-04-13
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.
Nat.Chem.Biol., 12, 2016
2WUL
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CRYSTAL STRUCTURE OF THE HUMAN GLUTAREDOXIN 5 WITH BOUND GLUTATHIONE IN AN FES CLUSTER
分子名称:GLUTAREDOXIN RELATED PROTEIN 5, GLUTATHIONE, FE2/S2 (INORGANIC) CLUSTER, ...
著者Roos, A.K., Johansson, C., Guo, K., Yue, W.W., Pike, A.C.W., Cooper, C.D.O., Pilka, E.S., Kavanagh, K.L., Chaikuad, A., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
登録日2009-10-06
公開日2009-10-20
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The Crystal Structure of Human Glrx5: Iron Sulphur Cluster Coordination, Tetrameric Assembly and Monomer Activity.
Biochem.J., 433, 2011
6QPL
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CRYSTAL STRUCTURE OF SPINDLIN1 IN COMPLEX WITH THE INHIBITOR MS31
分子名称:Spindlin-1, (4S)-2-METHYL-2,4-PENTANEDIOL, DIMETHYL SULFOXIDE, ...
著者Johansson, C., Krojer, T., Xiong, Y., Jin, J., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U.C.T.
登録日2019-02-14
公開日2019-07-17
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1).
J.Med.Chem., 2019
1ZSY
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THE STRUCTURE OF HUMAN MITOCHONDRIAL 2-ENOYL THIOESTER REDUCTASE (CGI-63)
分子名称:MITOCHONDRIAL 2-ENOYL THIOESTER REDUCTASE, SULFATE ION, GLYCEROL
著者Lukacik, P., Shafqat, N., Kavanagh, K.L., Johansson, C., Smee, C., Edwards, A., Arrowsmith, C., Sundstrom, M., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC)
登録日2005-05-25
公開日2005-06-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献The structure of human mitochondrial 2-enoyl thioester reductase (CGI-63)
To be Published
2C46
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CRYSTAL STRUCTURE OF THE HUMAN RNA GUANYLYLTRANSFERASE AND 5'- PHOSPHATASE
分子名称:MRNA CAPPING ENZYME
著者Debreczeni, J., Johansson, C., Longman, E., Gileadi, O., SavitskySmee, P., Smee, C., Bunkoczi, G., Ugochukwu, E., von Delft, F., Sundstrom, M., Weigelt, J., Arrowsmith, C., Edwards, A., Knapp, S.
登録日2005-10-15
公開日2005-11-01
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal Structure of the Human RNA Guanylyltransferase and 5'-Phosphatase
To be Published
2F5Y
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CRYSTAL STRUCTURE OF THE PDZ DOMAIN FROM HUMAN RGS-3
分子名称:regulator of G-protein signalling 3 isoform 1, SULFATE ION
著者Ugochukwu, E., Berridge, G., Johansson, C., Smee, C., Savitsky, P., Burgess, N., Colebrook, S., Yang, X., Elkins, J., Doyle, D., Turnbull, A., Papagrigoriou, E., Debreczeni, J., Bunkoczi, G., Gorrec, F., von Delft, F., Arrowsmith, C., Sundstrom, M., Weigelt, J., Edwards, A., Structural Genomics Consortium (SGC)
登録日2005-11-28
公開日2005-12-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Crystal Structure of the PDZ Domain from Human RGS-3
To be Published
2FV8
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THE CRYSTAL STRUCTURE OF RHOB IN THE GDP-BOUND STATE
分子名称:Rho-related GTP-binding protein RhoB, GUANOSINE-5'-DIPHOSPHATE
著者Turnbull, A.P., Soundararajan, M., Smee, C., Johansson, C., Schoch, G., Gorrec, F., Bray, J., Papagrigoriou, E., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Doyle, D., Structural Genomics Consortium (SGC)
登録日2006-01-30
公開日2006-02-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The crystal structure of RhoB in the GDP-bound state
To be Published
2IIK
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CRYSTAL STRUCTURE OF HUMAN PEROXISOMAL ACETYL-COA ACYL TRANSFERASE 1 (ACAA1)
分子名称:3-ketoacyl-CoA thiolase, peroxisomal
著者Papagrigoriou, E., Johansson, C., Smee, C., Kavanagh, K., Pike, A.C.W., Sundstrom, M., Weigelt, J., Edwards, A., Arrowsmith, C.H., Gileadi, O., Gorrec, F., Umeano, C., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC)
登録日2006-09-28
公開日2006-10-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Crystal Structure of human peroxisomal acetyl-CoA acyl transferase 1 (ACAA1)
TO BE PUBLISHED