7QC2

Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline-tRNA ligase) from Plasmodium falciparum in complex with MAT334 and L-Proline

Summary for 7QC2

• Entry DOI: 10.2210/pdb7qc2/pdb
• Descriptor: Proline--tRNA ligase, PROLINE, ~{N}-(2,3-dihydro-1~{H}-inden-2-yl)-3-[[4-[[(2~{S})-pyrrolidin-2-yl]carbonylamino]piperidin-1-yl]carbonylamino]pyrazine-2-carboxamide, ... (5 entities in total)
• Functional Keywords: proline, aminoacyl-trna synthetase, ligase, protein biosynthesis
• Biological source: Plasmodium falciparum (isolate 3D7)
• Total number of polymer chains: 1
• Total formula weight: 59305.82

Authors

Johansson, C.,Tye, M.,Payne, N.C.,Mazitschek, R.,Oppermann, U.C.T. (deposition date: 2021-11-22, release date: 2022-05-04, Last modification date: 2024-01-31)

• Primary citation: Johansson, C.,Tye, M.,Payne, N.C.,Mazitschek, R.,Oppermann, U.C.T.; Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline-tRNA ligase) from Plasmodium falciparum in complex with MAT334 and L-Proline; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.28 Å)