7QC2
Crystal Structure of Prolyl-tRNA synthetase (ProRS, Proline-tRNA ligase) from Plasmodium falciparum in complex with MAT334 and L-Proline
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Proline--tRNA ligase | polymer | 504 | 58526.9 | 1 | UniProt (Q8I5R7) Pfam (PF00587) Pfam (PF03129) Pfam (PF09180) | Plasmodium falciparum (isolate 3D7) | Prolyl-tRNA synthetase,ProRS |
| 2 | B (A) | PROLINE | non-polymer | 115.1 | 1 | Chemie (PRO) | |||
| 3 | C (A) | ~{N}-(2,3-dihydro-1~{H}-inden-2-yl)-3-[[4-[[(2~{S})-pyrrolidin-2-yl]carbonylamino]piperidin-1-yl]carbonylamino]pyrazine-2-carboxamide | non-polymer | 477.6 | 1 | Chemie (AJT) | |||
| 4 | D, E, F (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 5 | G (A) | water | water | 18.0 | 45 | Chemie (HOH) |
Sequence modifications
A: 249 - 746 (UniProt: Q8I5R7)
| PDB | External Database | Details |
|---|---|---|
| Ser 243 | - | expression tag |
| Asp 244 | - | expression tag |
| Asn 245 | - | expression tag |
| Ala 246 | - | expression tag |
| Ile 247 | - | expression tag |
| Ala 248 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 58526.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 778.9 | |
| All* | Total formula weight | 59305.8 |
