Author results

4CMP
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CRYSTAL STRUCTURE OF S. PYOGENES CAS9
Descriptor:CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, SULFATE ION, MAGNESIUM ION
Authors:Jinek, M., Jiang, F., Taylor, D.W., Sternberg, S.H., Kaya, E., Ma, E., Anders, C., Hauer, M., Zhou, K., Lin, S., Kaplan, M., Iavarone, A.T., Charpentier, E., Nogales, E., Doudna, J.A.
Deposit date:2014-01-16
Release date:2014-02-12
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation.
Science, 343, 2014
4CMQ
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CRYSTAL STRUCTURE OF MN-BOUND S.PYOGENES CAS9
Descriptor:CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MANGANESE (II) ION, SULFATE ION
Authors:Jinek, M., Jiang, F., Taylor, D.W., Sternberg, S.H., Kaya, E., Ma, E., Anders, C., Hauer, M., Zhou, K., Lin, S., Kaplan, M., Iavarone, A.T., Charpentier, E., Nogales, E., Doudna, J.A.
Deposit date:2014-01-17
Release date:2014-02-12
Last modified:2014-03-26
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Structures of Cas9 Endonucleases Reveal RNA- Mediated Conformational Activation
Science, 343, 2014
1W3B
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THE SUPERHELICAL TPR DOMAIN OF O-LINKED GLCNAC TRANSFERASE REVEALS STRUCTURAL SIMILARITIES TO IMPORTIN ALPHA.
Descriptor:UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110, CALCIUM ION
Authors:Jinek, M., Rehwinkel, J., Lazarus, B.D., Izaurralde, E., Hanover, J.A., Conti, E.
Deposit date:2004-07-14
Release date:2004-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The Superhelical Tpr-Repeat Domain of O-Linked Glcnac Transferase Exhibits Structural Similarities to Importin Alpha
Nat.Struct.Mol.Biol., 11, 2004
2J0A
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STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE
Descriptor:BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE, SULFATE ION, POTASSIUM ION
Authors:Jinek, M., Chen, Y.-W., Clausen, H., Cohen, S.M., Conti, E.
Deposit date:2006-08-01
Release date:2006-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Insights Into the Notch-Modifying Glycosyltransferase Fringe
Nat.Struct.Mol.Biol., 13, 2006
2J0B
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STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE IN COMPLEX WITH UDP AND MANGANESE
Descriptor:BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE MANIC FRINGE, SULFATE ION, POTASSIUM ION, ...
Authors:Jinek, M., Chen, Y.-W., Clausen, H., Cohen, S.M., Conti, E.
Deposit date:2006-08-01
Release date:2006-09-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Insights Into the Notch-Modifying Glycosyltransferase Fringe
Nat.Struct.Mol.Biol., 13, 2006
2VXG
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CRYSTAL STRUCTURE OF THE CONSERVED C-TERMINAL REGION OF GE-1
Descriptor:CG6181-PA, ISOFORM A
Authors:Jinek, M., Eulalio, A., Lingel, A., Helms, S., Conti, E., Izaurralde, E.
Deposit date:2008-07-04
Release date:2008-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The C-Terminal Region of Ge-1 Presents Conserved Structural Features Required for P-Body Localization.
RNA, 14, 2008
2X04
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CRYSTAL STRUCTURE OF THE PABC-TNRC6C COMPLEX
Descriptor:POLYADENYLATE-BINDING PROTEIN 1, TRINUCLEOTIDE REPEAT-CONTAINING GENE 6C PROTEIN, SULFATE ION
Authors:Jinek, M., Fabian, M.R., Coyle, S.M., Sonenberg, N., Doudna, J.A.
Deposit date:2009-12-04
Release date:2010-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Structural Insights Into the Human Gw182-Pabc Interaction in Microrna-Mediated Deadenylation
Nat.Struct.Mol.Biol., 17, 2010
2Y35
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CRYSTAL STRUCTURE OF XRN1-SUBSTRATE COMPLEX
Descriptor:LD22664P, DT11 (5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP)-3', MAGNESIUM ION
Authors:Jinek, M., Coyle, S.M., Doudna, J.A.
Deposit date:2010-12-18
Release date:2011-03-16
Last modified:2011-08-03
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Coupled 5' Nucleotide Recognition and Processivity in Xrn1-Mediated Mrna Decay.
Mol.Cell, 41, 2011
4C8Y
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CAS6 (TTHA0078) SUBSTRATE MIMIC COMPLEX
Descriptor:CAS6A, R1 REPEAT RNA SUBSTRATE MIMIC, SULFATE ION
Authors:Jinek, M., Niewoehner, O., Doudna, J.A.
Deposit date:2013-10-02
Release date:2013-11-06
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
Nucleic Acids Res., 42, 2014
4C8Z
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CAS6 (TTHA0078) PRODUCT COMPLEX
Descriptor:CAS6A, R1 REPEAT RNA CLEAVAGE PRODUCT, SULFATE ION, ...
Authors:Jinek, M., Niewoehner, O., Doudna, J.A.
Deposit date:2013-10-02
Release date:2013-11-06
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (2.503 Å)
Cite:Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
Nucleic Acids Res., 42, 2014
4C97
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CAS6 (TTHA0078) H37A MUTANT
Descriptor:CAS6A, SULFATE ION
Authors:Jinek, M., Niewoehner, O., Doudna, J.A.
Deposit date:2013-10-02
Release date:2013-11-06
Last modified:2014-07-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
Nucleic Acids Res., 42, 2014
4C98
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THERMUS THERMOPHILUS CAS6 (TTHB231)
Descriptor:CAS6B, ZINC ION
Authors:Jinek, M., Niewoehner, O., Doudna, J.A.
Deposit date:2013-10-02
Release date:2013-11-06
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
Nucleic Acids Res., 42, 2014
4C9D
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CAS6 (TTHB231) PRODUCT COMPLEX
Descriptor:CAS6B, R3 REPEAT RNA CLEAVAGE PRODUCT
Authors:Jinek, M., Niewoehner, O., Doudna, J.A.
Deposit date:2013-10-02
Release date:2013-11-06
Last modified:2017-03-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases.
Nucleic Acids Res., 42, 2014
6F9S
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CRYSTAL STRUCTURE OF THE C-TERMINAL RECA DOMAIN OF DDX6 IN COMPLEX WITH A CONSERVED PEPTIDE FROM LSM14
Descriptor:Probable ATP-dependent RNA helicase DDX6, Cytokinesis, Apoptosis, ...
Authors:Jinek, M., Brandmann, T.
Deposit date:2017-12-15
Release date:2018-03-21
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes.
EMBO J., 37, 2018
6FDL
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CRYSTAL STRUCTURE OF THE NYN DOMAIN OF HUMAN MARF1
Descriptor:Meiosis regulator and mRNA stability factor 1
Authors:Jinek, M., Brandmann, T.
Deposit date:2017-12-26
Release date:2018-11-07
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs.
Nucleic Acids Res., 46, 2018
6I1K
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CRYSTAL STRUCTURE OF CATALYTICALLY INACTIVE FNCAS12A IN COMPLEX WITH A CRRNA GUIDE AND A DSDNA TARGET
Descriptor:CRISPR-associated endonuclease Cas12a, crRNA (40-MER), DNA target strand (38-MER), ...
Authors:Jinek, M., Swarts, D.C.
Deposit date:2018-10-29
Release date:2019-01-23
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a.
Mol. Cell, 73, 2019
6I1L
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CRYSTAL STRUCTURE OF FNCAS12A IN COMPLEX WITH A CRRNA GUIDE AND SSDNA TARGET
Descriptor:CRISPR-associated endonuclease Cas12a, crRNA (40-MER), ssDNA target strand, ...
Authors:Jinek, M., Swarts, D.C.
Deposit date:2018-10-29
Release date:2019-01-23
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a.
Mol. Cell, 73, 2019
5FQ5
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CRYSTAL STRUCTURE OF CAS9-SGRNA-DNA COMPLEX SOLVED BY NATIVE SAD PHASING
Descriptor:SGRNA, CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, TARGET DNA STRAND PROXIMAL FRAGMENT, ...
Authors:Olieric, V., Weinert, T., Finke, A., Anders, C., Jinek, M., Wang, M.
Deposit date:2015-12-07
Release date:2016-03-23
Method:X-RAY DIFFRACTION (2.136 Å)
Cite:Data-Collection Strategy for Challenging Native Sad Phasing.
Acta Crystallogr.,Sect.D, 72, 2016
6F9N
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CRYSTAL STRUCTURE OF THE HUMAN CPSF160-WDR33 COMPLEX
Descriptor:Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33
Authors:Clerici, M., Jinek, M.
Deposit date:2017-12-14
Release date:2018-01-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex.
Elife, 6, 2017
6FBS
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CRYO-EM STRUCTURE OF THE HUMAN CPSF160-WDR33-CPSF30 COMPLEX BOUND TO THE PAS AAUAAA MOTIF AT 3.1 ANGSTROM RESOLUTION
Descriptor:Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33, Cleavage and polyadenylation specificity factor subunit 4, ...
Authors:Clerici, M., Faini, M., Jinek, M.
Deposit date:2017-12-19
Release date:2018-01-31
Last modified:2018-02-21
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex.
Nat. Struct. Mol. Biol., 25, 2018
6FUW
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CRYO-EM STRUCTURE OF THE HUMAN CPSF160-WDR33-CPSF30 COMPLEX BOUND TO THE PAS AAUAAA MOTIF AT 3.1 ANGSTROM RESOLUTION
Descriptor:Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33, Cleavage and polyadenylation specificity factor subunit 4, ...
Authors:Clerici, M., Faini, M., Jinek, M.
Deposit date:2018-02-28
Release date:2018-03-21
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex.
Nat. Struct. Mol. Biol., 25, 2018
2XLI
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CRYSTAL STRUCTURE OF THE CSY4-CRRNA COMPLEX, MONOCLINIC FORM
Descriptor:CSY4 ENDORIBONUCLEASE, 5'-R(*CP*UP*GP*CP*CP*GP*UP*AP*UP*AP*GP*GP*CP*A*DG*C)-3'
Authors:Haurwitz, R.E., Jinek, M., Wiedenheft, B., Zhou, K., Doudna, J.A.
Deposit date:2010-07-20
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Sequence- and Structure-Specific RNA Processing by a Crispr Endonuclease.
Science, 329, 2010
2XLJ
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CRYSTAL STRUCTURE OF THE CSY4-CRRNA COMPLEX, HEXAGONAL FORM
Descriptor:CSY4 ENDORIBONUCLEASE, 5'-R(*CP*UP*GP*CP*CP*GP*UP*AP*UP*AP*GP*GP*CP*A*DG*C)-3'
Authors:Haurwitz, R.E., Jinek, M., Wiedenheft, B., Zhou, K., Doudna, J.A.
Deposit date:2010-07-20
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Sequence- and Structure-Specific RNA Processing by a Crispr Endonuclease.
Science, 329, 2010
2XLK
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CRYSTAL STRUCTURE OF THE CSY4-CRRNA COMPLEX, ORTHORHOMBIC FORM
Descriptor:CSY4 ENDORIBONUCLEASE, 5'-R(*CP*UP*GP*CP*CP*GP*UP*AP*UP*AP*GP*GP*CP*A*DG*C)-3'
Authors:Haurwitz, R.E., Jinek, M., Wiedenheft, B., Zhou, K., Doudna, J.A.
Deposit date:2010-07-21
Release date:2010-09-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.805 Å)
Cite:Sequence- and Structure-Specific RNA Processing by a Crispr Endonuclease.
Science, 329, 2010
2Y8W
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STRUCTURE OF CRISPR ENDORIBONUCLEASE CSE3 BOUND TO 20 NT RNA
Descriptor:CSE3, 5'-R(*UP*CP*CP*CP*CP*AP*CP*GP*CP*GP*UP*GP*UP*GP *GP*GP*DGP*AP*UP*G)-3'
Authors:Sashital, D.G., Jinek, M., Doudna, J.A.
Deposit date:2011-02-11
Release date:2011-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:An RNA-Induced Conformational Change Required for Crispr RNA Cleavage by the Endoribonuclease Cse3.
Nat.Struct.Mol.Biol., 18, 2011
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