7SJ0
 
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8CW9
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7TJQ
 | | SAN27-14 bound to a antigenic site V on prefusion-stabilized hMPV F | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, MPE8 Fab heavy chain, ... | | Authors: | Hsieh, C.-L, McLellan, J.S, Rush, S.A. | | Deposit date: | 2022-01-16 | | Release date: | 2022-09-14 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.13 Å) | | Cite: | Characterization of prefusion-F-specific antibodies elicited by natural infection with human metapneumovirus.
Cell Rep, 40, 2022
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8TMA
 | | Antibody N3-1 bound to RBD in the up conformation | | Descriptor: | N3-1 Fab heavy chain, N3-1 Fab light chain, Spike glycoprotein | | Authors: | Hsieh, C.-L, McLellan, J.S. | | Deposit date: | 2023-07-29 | | Release date: | 2024-01-17 | | Last modified: | 2025-05-14 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | SARS-COV-2 Omicron variants conformationally escape a rare quaternary antibody binding mode.
Commun Biol, 6, 2023
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8TM1
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7SEJ
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8U1G
 | | Prefusion-stabilized SARS-CoV-2 S2 subunit | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S2 | | Authors: | Hsieh, C.-L, McLellan, J.S. | | Deposit date: | 2023-08-31 | | Release date: | 2024-01-24 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge.
Nat Commun, 15, 2024
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7LVW
 | | Structure of RSV F in Complex with VHH Cl184 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, F-VHH-Cl184, ... | | Authors: | Hsieh, C.-L, McLellan, J.S. | | Deposit date: | 2021-02-26 | | Release date: | 2021-03-24 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | A vulnerable, membrane-proximal site in human respiratory syncytial virus F revealed by a prefusion-specific single-domain antibody.
J.Virol., 95, 2021
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7LVU
 | | Structure of RSV F-directed VHH Cl184 | | Descriptor: | F-VHH-Cl184 | | Authors: | Hsieh, C.-L, McLellan, J.S. | | Deposit date: | 2021-02-26 | | Release date: | 2021-03-24 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | A vulnerable, membrane-proximal site in human respiratory syncytial virus F revealed by a prefusion-specific single-domain antibody.
J.Virol., 95, 2021
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6XKL
 | | SARS-CoV-2 HexaPro S One RBD up | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | | Authors: | Wrapp, D, Hsieh, C.-L, Goldsmith, J.A, McLellan, J.S. | | Deposit date: | 2020-06-26 | | Release date: | 2020-07-15 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Structure-based design of prefusion-stabilized SARS-CoV-2 spikes.
Science, 369, 2020
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9F21
 | | Crystal structure of Borrelia burgdorferi CspZ-YACS | | Descriptor: | Complement regulator-acquiring surface protein 2 (CRASP-2), SULFATE ION | | Authors: | Brangulis, K, Malfetano, J, Marcinkiewicz, A.L, Wang, A, Chen, Y.-L, Yang, X, Lee, W, Bottazzi, M.-E, Pal, U, Hsieh, C.-L, Chen, W.-H, Lin, Y.-P. | | Deposit date: | 2024-04-20 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Mechanistic insights into the structure-based design of a CspZ-targeting Lyme disease vaccine.
Nat Commun, 16, 2025
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9F1V
 | | Crystal structure of Borrelia burgdorferi CspZ-YA | | Descriptor: | Complement regulator-acquiring surface protein 2 (CRASP-2) | | Authors: | Brangulis, K, Malfetano, J, Marcinkiewicz, A.L, Wang, A, Chen, Y.-L, Yang, X, Lee, W, Bottazzi, M.-E, Pal, U, Hsieh, C.-L, Chen, W.-H, Lin, Y.-P. | | Deposit date: | 2024-04-20 | | Release date: | 2025-04-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Mechanistic insights into the structure-based design of a CspZ-targeting Lyme disease vaccine.
Nat Commun, 16, 2025
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7TL0
 | | Cryo-EM structure of hMPV preF bound by Fabs MPE8 and SAN32-2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, ... | | Authors: | Rush, S.A, Hsieh, C.-L, McLellan, J.S. | | Deposit date: | 2022-01-17 | | Release date: | 2022-09-14 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | Characterization of prefusion-F-specific antibodies elicited by natural infection with human metapneumovirus.
Cell Rep, 40, 2022
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7SEM
 | | Structure-based design of prefusion-stabilized human metapneumovirus fusion proteins | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, MPE8 Fab heavy chain, ... | | Authors: | Rush, S.A, Hsieh, C.-L, McLellan, J.S. | | Deposit date: | 2021-09-30 | | Release date: | 2022-02-16 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structure-based design of prefusion-stabilized human metapneumovirus fusion proteins.
Nat Commun, 13, 2022
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