8CW9

Prefusion-stabilized hMPV fusion protein bound to ADI-61026 and MPE8 Fabs

Summary for 8CW9

Entry DOI	10.2210/pdb8cw9/pdb
EMDB information	27024
Descriptor	Fusion glycoprotein F0, MPE8 light chain, ADI-61026 heavy, ... (6 entities in total)
Functional Keywords	site 0 neutralizing antibody, prefusion-stabilized hmpv f protein, viral protein, viral protein-immune system complex, viral protein/immune system
Biological source	Human metapneumovirus More
Total number of polymer chains	15
Total formula weight	541479.03
Authors	Hsieh, C.-L.,McLellan, J.S. (deposition date: 2022-05-18, release date: 2022-08-10, Last modification date: 2023-02-22)
Primary citation	Rappazzo, C.G.,Hsieh, C.L.,Rush, S.A.,Esterman, E.S.,Delgado, T.,Geoghegan, J.C.,Wec, A.Z.,Sakharkar, M.,Mas, V.,McLellan, J.S.,Walker, L.M. Potently neutralizing and protective anti-human metapneumovirus antibodies target diverse sites on the fusion glycoprotein. Immunity, 55:1710-1724.e8, 2022 Cited by PubMed: 35944529 DOI: 10.1016/j.immuni.2022.07.003 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.46 Å)

Structure validation