8CW9
Prefusion-stabilized hMPV fusion protein bound to ADI-61026 and MPE8 Fabs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, E, F (A, E, F) | Fusion glycoprotein F0 | polymer | 551 | 60453.9 | 3 | UniProt (H6X1Z0) Pfam (PF00523) | Human metapneumovirus | Fusion glycoprotein F1,Fusion glycoprotein F2 |
| 2 | B, M, O (B, M, O) | MPE8 light chain | polymer | 216 | 22772.1 | 3 | Homo sapiens | ||
| 3 | C, H, I (C, H, I) | ADI-61026 heavy | polymer | 228 | 24699.9 | 3 | Homo sapiens | ||
| 4 | D, K, L (D, K, L) | ADI-61026 light | polymer | 214 | 22912.4 | 3 | Homo sapiens | ||
| 5 | G, J, N (G, J, N) | MPE8 heavy chain | polymer | 454 | 49433.5 | 3 | Homo sapiens | ||
| 6 | P, Q, R (A, E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) |
Sequence modifications
A, E, F: 1 - 490 (UniProt: H6X1Z0)
| PDB | External Database | Details |
|---|---|---|
| Arg 100 | Gln 100 | engineered mutation |
| Arg 101 | Ser 101 | engineered mutation |
| Cys 110 | Leu 110 | engineered mutation |
| Cys 127 | Thr 127 | engineered mutation |
| Cys 140 | Ala 140 | engineered mutation |
| Cys 147 | Ala 147 | engineered mutation |
| Cys 153 | Asn 153 | engineered mutation |
| Pro 185 | Ala 185 | engineered mutation |
| Lys 219 | Leu 219 | engineered mutation |
| Ile 231 | Val 231 | engineered mutation |
| Cys 322 | Asn 322 | engineered mutation |
| Cys 365 | Thr 365 | engineered mutation |
| Gln 453 | Glu 453 | engineered mutation |
| Cys 463 | Val 463 | engineered mutation |
| Gly 491 | - | expression tag |
| Gly 492 | - | expression tag |
| Gly 493 | - | expression tag |
| Ser 494 | - | expression tag |
| Gly 495 | - | expression tag |
| Tyr 496 | - | expression tag |
| Ile 497 | - | expression tag |
| Pro 498 | - | expression tag |
| Glu 499 | - | expression tag |
| Ala 500 | - | expression tag |
| Pro 501 | - | expression tag |
| Arg 502 | - | expression tag |
| Asp 503 | - | expression tag |
| Gly 504 | - | expression tag |
| Gln 505 | - | expression tag |
| Ala 506 | - | expression tag |
| Tyr 507 | - | expression tag |
| Val 508 | - | expression tag |
| Arg 509 | - | expression tag |
| Lys 510 | - | expression tag |
| Asp 511 | - | expression tag |
| Gly 512 | - | expression tag |
| Glu 513 | - | expression tag |
| Trp 514 | - | expression tag |
| Val 515 | - | expression tag |
| Leu 516 | - | expression tag |
| Leu 517 | - | expression tag |
| Ser 518 | - | expression tag |
| Thr 519 | - | expression tag |
| Phe 520 | - | expression tag |
| Leu 521 | - | expression tag |
| Gly 522 | - | expression tag |
| Arg 523 | - | expression tag |
| Ser 524 | - | expression tag |
| Leu 525 | - | expression tag |
| Glu 526 | - | expression tag |
| Val 527 | - | expression tag |
| Leu 528 | - | expression tag |
| Phe 529 | - | expression tag |
| Gln 530 | - | expression tag |
| Gly 531 | - | expression tag |
| Pro 532 | - | expression tag |
| Gly 533 | - | expression tag |
| His 534 | - | expression tag |
| His 535 | - | expression tag |
| His 536 | - | expression tag |
| His 537 | - | expression tag |
| His 538 | - | expression tag |
| His 539 | - | expression tag |
| His 540 | - | expression tag |
| His 541 | - | expression tag |
| Ser 542 | - | expression tag |
| Ala 543 | - | expression tag |
| Trp 544 | - | expression tag |
| Ser 545 | - | expression tag |
| His 546 | - | expression tag |
| Pro 547 | - | expression tag |
| Gln 548 | - | expression tag |
| Phe 549 | - | expression tag |
| Glu 550 | - | expression tag |
| Lys 551 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 15 |
| Total formula weight | 540815.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 663.6 | |
| All* | Total formula weight | 541479.0 |
