Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
2CTI
DownloadVisualize
BU of 2cti by Molmil
DETERMINATION OF THE COMPLETE THREE-DIMENSIONAL STRUCTURE OF THE TRYPSIN INHIBITOR FROM SQUASH SEEDS IN AQUEOUS SOLUTION BY NUCLEAR MAGNETIC RESONANCE AND A COMBINATION OF DISTANCE GEOMETRY AND DYNAMICAL SIMULATED ANNEALING
Descriptor: TRYPSIN INHIBITOR
Authors:Holak, T.A, Gondol, D, Otlewski, J, Wilusz, T.
Deposit date:1990-08-28
Release date:1992-01-15
Last modified:2024-10-30
Method:SOLUTION NMR
Cite:Determination of the complete three-dimensional structure of the trypsin inhibitor from squash seeds in aqueous solution by nuclear magnetic resonance and a combination of distance geometry and dynamical simulated annealing.
J.Mol.Biol., 210, 1989
1CTI
DownloadVisualize
BU of 1cti by Molmil
DETERMINATION OF THE COMPLETE THREE-DIMENSIONAL STRUCTURE OF THE TRYPSIN INHIBITOR FROM SQUASH SEEDS IN AQUEOUS SOLUTION BY NUCLEAR MAGNETIC RESONANCE AND A COMBINATION OF DISTANCE GEOMETRY AND DYNAMICAL SIMULATED ANNEALING
Descriptor: TRYPSIN INHIBITOR
Authors:Holak, T.A, Gondol, D, Otlewski, J, Wilusz, T.
Deposit date:1990-08-28
Release date:1992-01-15
Last modified:2024-11-20
Method:SOLUTION NMR
Cite:Determination of the complete three-dimensional structure of the trypsin inhibitor from squash seeds in aqueous solution by nuclear magnetic resonance and a combination of distance geometry and dynamical simulated annealing.
J.Mol.Biol., 210, 1989
3CTI
DownloadVisualize
BU of 3cti by Molmil
RELAXATION MATRIX REFINEMENT OF THE SOLUTION STRUCTURE OF SQUASH TRYPSIN INHIBITOR
Descriptor: TRYPSIN INHIBITOR
Authors:Nilges, M, Habazettl, J, Bruenger, A.T, Holak, T.A.
Deposit date:1991-03-27
Release date:1992-04-15
Last modified:2024-10-23
Method:SOLUTION NMR
Cite:Relaxation matrix refinement of the solution structure of squash trypsin inhibitor.
J.Mol.Biol., 219, 1991
3JU0
DownloadVisualize
BU of 3ju0 by Molmil
Structure of the arm-type binding domain of HAI7 integrase
Descriptor: Phage integrase
Authors:Szwagierczak, A, Antonenka, U, Popowicz, G.M, Sitar, T, Holak, T.A, Rakin, A.
Deposit date:2009-09-14
Release date:2009-10-06
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of the arm-type binding domains of HPI and HAI7 integrases
J.Biol.Chem., 284, 2009
1KSR
DownloadVisualize
BU of 1ksr by Molmil
THE REPEATING SEGMENTS OF THE F-ACTIN CROSS-LINKING GELATION FACTOR (ABP-120) HAVE AN IMMUNOGLOBULIN FOLD, NMR, 20 STRUCTURES
Descriptor: GELATION FACTOR
Authors:Fucini, P, Renner, C, Herberhold, C, Noegel, A.A, Holak, T.A.
Deposit date:1997-02-07
Release date:1997-08-20
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:The repeating segments of the F-actin cross-linking gelation factor (ABP-120) have an immunoglobulin-like fold.
Nat.Struct.Biol., 4, 1997
2ABZ
DownloadVisualize
BU of 2abz by Molmil
Crystal structure of C19A/C43A mutant of leech carboxypeptidase inhibitor in complex with bovine carboxypeptidase A
Descriptor: Carboxypeptidase A1, Metallocarboxypeptidase inhibitor, ZINC ION
Authors:Arolas, J.L, Popowicz, G.M, Bronsoms, S, Aviles, F.X, Huber, R, Holak, T.A, Ventura, S.
Deposit date:2005-07-18
Release date:2006-01-31
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Study of a major intermediate in the oxidative folding of leech carboxypeptidase inhibitor: contribution of the fourth disulfide bond
J.Mol.Biol., 352, 2005
7NLD
DownloadVisualize
BU of 7nld by Molmil
Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor
Descriptor: N-(2-((2'-chloro-3'-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-methoxy-[1,1'-biphenyl]-4-yl)(methyl)amino)ethyl)methanesulfonamide, Programmed cell death 1 ligand 1
Authors:Sala, D, Magiera-Mularz, K, Muszak, D, Surmiak, E, Grudnik, P, Holak, T.A.
Deposit date:2021-02-22
Release date:2021-08-11
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Terphenyl-Based Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein-Protein Interaction.
J.Med.Chem., 64, 2021
6YCR
DownloadVisualize
BU of 6ycr by Molmil
Structure of human PD-L1 in complex with inhibitor
Descriptor: FFIVIRDRVFR(CCS)G(NH2), Programmed cell death 1 ligand 1
Authors:Magiera-Mularz, K, Grudnik, P, Kuska, K, Holak, T.A, Dubin, G.
Deposit date:2020-03-18
Release date:2021-02-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Macrocyclic Peptide Inhibitor of PD-1/PD-L1 Immune Checkpoint
Adv. Ther., 2020
4PYU
DownloadVisualize
BU of 4pyu by Molmil
The conserved ubiquitin-like protein hub1 plays a critical role in splicing in human cells
Descriptor: U4/U6.U5 tri-snRNP-associated protein 1, Ubiquitin-like protein 5
Authors:Ammon, T, Mishra, S.K, Kowalska, K, Popowicz, G.M, Holak, T.A, Jentsch, S.
Deposit date:2014-03-28
Release date:2014-07-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells.
J Mol Cell Biol, 6, 2014
1ZFI
DownloadVisualize
BU of 1zfi by Molmil
Solution structure of the leech carboxypeptidase inhibitor
Descriptor: Metallocarboxypeptidase inhibitor
Authors:Arolas, J.L, D'Silva, L, Popowicz, G.M, Aviles, F.X, Holak, T.A, Ventura, S.
Deposit date:2005-04-20
Release date:2005-09-13
Last modified:2024-10-16
Method:SOLUTION NMR
Cite:NMR structural characterization and computational predictions of the major intermediate in oxidative folding of leech carboxypeptidase inhibitor
STRUCTURE, 13, 2005
1ZFL
DownloadVisualize
BU of 1zfl by Molmil
Solution structure of III-A, the major intermediate in the oxidative folding of leech carboxypeptidase inhibitor
Descriptor: Metallocarboxypeptidase inhibitor
Authors:Arolas, J.L, D'Silva, L, Popowicz, G.M, Aviles, F.X, Holak, T.A, Ventura, S.
Deposit date:2005-04-20
Release date:2005-09-13
Last modified:2024-11-20
Method:SOLUTION NMR
Cite:NMR structural characterization and computational predictions of the major intermediate in oxidative folding of leech carboxypeptidase inhibitor
STRUCTURE, 13, 2005
4MDQ
DownloadVisualize
BU of 4mdq by Molmil
Structure of a novel submicromolar MDM2 inhibitor
Descriptor: 3-[(1R)-2-(benzylamino)-1-{[(2S)-1-(hydroxyamino)-4-methyl-1-oxopentan-2-yl]amino}-2-oxoethyl]-6-chloro-N-hydroxy-1H-indole-2-carboxamide, E3 ubiquitin-protein ligase Mdm2
Authors:Bista, M, Popowicz, G, Holak, T.A.
Deposit date:2013-08-23
Release date:2013-11-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.119 Å)
Cite:Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction.
Structure, 21, 2013
4MDN
DownloadVisualize
BU of 4mdn by Molmil
Structure of a novel submicromolar MDM2 inhibitor
Descriptor: 3-{(1S)-2-(tert-butylamino)-1-[{4-[(4-chlorobenzyl)oxy]benzyl}(formyl)amino]-2-oxoethyl}-6-chloro-1H-indole-2-carboxylic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION
Authors:Bista, M, Popowicz, G, Holak, T.A.
Deposit date:2013-08-23
Release date:2013-11-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.905 Å)
Cite:Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction.
Structure, 21, 2013
3DAC
DownloadVisualize
BU of 3dac by Molmil
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
Descriptor: Cellular tumor antigen p53, Mdm4 protein
Authors:Popowicz, G.M, Czarna, A, Holak, T.A.
Deposit date:2008-05-29
Release date:2008-09-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.
Cell Cycle, 7, 2008
3DAB
DownloadVisualize
BU of 3dab by Molmil
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
Descriptor: Cellular tumor antigen p53, Mdm4 protein
Authors:Popowicz, G.M, Czarna, A, Holak, T.A.
Deposit date:2008-05-29
Release date:2008-09-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.
Cell Cycle, 7, 2008
3FDO
DownloadVisualize
BU of 3fdo by Molmil
Structure of human MDMX in complex with high affinity peptide
Descriptor: MAGNESIUM ION, Protein Mdm4, Synthetic high affinity peptide
Authors:Czarna, A.L, Popowicz, G.M, Holak, T.A.
Deposit date:2008-11-26
Release date:2008-12-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx.
Cell Cycle, 8, 2009
1WLH
DownloadVisualize
BU of 1wlh by Molmil
Molecular structure of the rod domain of Dictyostelium filamin
Descriptor: Gelation factor
Authors:Popowicz, G.M, Mueller, R, Noegel, A.A, Schleicher, M, Huber, R, Holak, T.A.
Deposit date:2004-06-27
Release date:2004-10-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular structure of the rod domain of dictyostelium filamin
J.Mol.Biol., 342, 2004
1WQJ
DownloadVisualize
BU of 1wqj by Molmil
Structural Basis for the Regulation of Insulin-Like Growth Factors (IGFs) by IGF Binding Proteins (IGFBPs)
Descriptor: Insulin-like growth factor IB, Insulin-like growth factor binding protein 4
Authors:Siwanowicz, I, Popowicz, G.M, Wisniewska, M, Huber, R, Kuenkele, K.P, Lang, K, Engh, R.A, Holak, T.A.
Deposit date:2004-09-29
Release date:2005-03-01
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis for the regulation of insulin-like growth factors by IGF binding proteins
Structure, 13, 2005
3G03
DownloadVisualize
BU of 3g03 by Molmil
Structure of human MDM2 in complex with high affinity peptide
Descriptor: E3 ubiquitin-protein ligase Mdm2, High affinity synthetic peptide
Authors:Czarna, A.L, Popowicz, G.M, Holak, T.A.
Deposit date:2009-01-27
Release date:2009-04-14
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx.
Cell Cycle, 8, 2009
3JTZ
DownloadVisualize
BU of 3jtz by Molmil
Structure of the arm-type binding domain of HPI integrase
Descriptor: Integrase, SODIUM ION
Authors:Szwagierczak, A, Antonenka, U, Popowicz, G.M, Sitar, T, Holak, T.A, Rakin, A.
Deposit date:2009-09-14
Release date:2009-10-06
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structures of the arm-type binding domains of HPI and HAI7 integrases
J.Biol.Chem., 284, 2009
8P1O
DownloadVisualize
BU of 8p1o by Molmil
Solubilizer tag effect on PD-L1/inhibitor binding properties for m-terphenyl derivatives
Descriptor: (3~{R})-1-[[4-[2-chloranyl-3-(2,3-dihydro-1,4-benzodioxin-6-yl)phenyl]-2-methoxy-phenyl]methyl]-~{N}-(2-hydroxyethyl)pyrrolidine-3-carboxamide, CHLORIDE ION, Programmed cell death 1 ligand 1, ...
Authors:Plewka, J, Magiera-Mularz, K, Surmiak, E, Kalinowska-Tluscik, J, Holak, T.A.
Deposit date:2023-05-12
Release date:2024-01-31
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Solubilizer Tag Effect on PD-L1/Inhibitor Binding Properties for m -Terphenyl Derivatives.
Acs Med.Chem.Lett., 15, 2024
5J7F
DownloadVisualize
BU of 5j7f by Molmil
Structure of MDM2 with low molecular weight inhibitor with aliphatic linker.
Descriptor: 4-({6-[(6-chloro-3-{1-[(4-chlorophenyl)methyl]-4-(4-fluorophenyl)-1H-imidazol-5-yl}-1H-indole-2-carbonyl)oxy]hexyl}amino)-4-oxobutanoic acid, E3 ubiquitin-protein ligase Mdm2
Authors:Twarda-Clapa, A, Kubica, K, Guzik, K, Dubin, G, Holak, T.A.
Deposit date:2016-04-06
Release date:2017-05-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers.
J. Med. Chem., 60, 2017
5J7G
DownloadVisualize
BU of 5j7g by Molmil
Structure of MDM2 with low molecular weight inhibitor with aliphatic linker.
Descriptor: 4-({6-[(6-chloro-3-{1-[(4-chlorophenyl)methyl]-4-(4-fluorophenyl)-1H-imidazol-5-yl}-1H-indole-2-carbonyl)oxy]hexyl}amino)-4-oxobutanoic acid, E3 ubiquitin-protein ligase Mdm2
Authors:Twarda-Clapa, A, Kubica, K, Guzik, K, Dubin, G, Holak, T.A.
Deposit date:2016-04-06
Release date:2017-05-17
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers.
J. Med. Chem., 60, 2017
5J8O
DownloadVisualize
BU of 5j8o by Molmil
Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor
Descriptor: (2R)-1-({3-bromo-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl}methyl)piperidine-2-carboxylic acid, Programmed cell death 1 ligand 1
Authors:Zak, K.M, Grudnik, P, Guzik, K, Zieba, B.J, Musielak, B, Doemling, P, Dubin, G, Holak, T.A.
Deposit date:2016-04-08
Release date:2016-04-27
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1).
Oncotarget, 7, 2016
5J89
DownloadVisualize
BU of 5j89 by Molmil
Structure of human Programmed cell death 1 ligand 1 (PD-L1) with low molecular mass inhibitor
Descriptor: 1,2-ETHANEDIOL, N-{2-[({2-methoxy-6-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]pyridin-3-yl}methyl)amino]ethyl}acetamide, Programmed cell death 1 ligand 1
Authors:Zak, K.M, Grudnik, P, Guzik, K, Zieba, B.J, Musielak, B, Doemling, P, Dubin, G, Holak, T.A.
Deposit date:2016-04-07
Release date:2016-04-27
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1).
Oncotarget, 7, 2016

238582

PDB entries from 2025-07-09

PDB statisticsPDBj update infoContact PDBjnumon