Author results

1DPB
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CRYSTALLOGRAPHIC AND ENZYMATIC INVESTIGATIONS ON THE ROLE OF SER558, HIS610 AND ASN614 IN THE CATALYTIC MECHANISM OF AZOTOBACTER VINELANDII DIHYDROLIPOAMIDE ACETYLTRANSFERASE (E2P)
分子名称:DIHYDROLIPOYL-TRANSACETYLASE
著者Hendle, J., Hol, W.G.J.
登録日1995-02-03
公開日1995-04-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystallographic and enzymatic investigations on the role of Ser558, His610, and Asn614 in the catalytic mechanism of Azotobacter vinelandii dihydrolipoamide acetyltransferase (E2p).
Biochemistry, 34, 1995
1DPC
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CRYSTALLOGRAPHIC AND ENZYMATIC INVESTIGATIONS ON THE ROLE OF SER558, HIS610 AND ASN614 IN THE CATALYTIC MECHANISM OF AZOTOBACTER VINELANDII DIHYDROLIPOAMIDE ACETYLTRANSFERASE (E2P)
分子名称:DIHYDROLIPOYL-TRANSACETYLASE
著者Hendle, J., Hol, W.G.J.
登録日1995-02-03
公開日1995-04-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystallographic and enzymatic investigations on the role of Ser558, His610, and Asn614 in the catalytic mechanism of Azotobacter vinelandii dihydrolipoamide acetyltransferase (E2p).
Biochemistry, 34, 1995
1DPD
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CRYSTALLOGRAPHIC AND ENZYMATIC INVESTIGATIONS ON THE ROLE OF SER558, HIS610 AND ASN614 IN THE CATALYTIC MECHANISM OF AZOTOBACTER VINELANDII DIHYDROLIPOAMIDE ACETYLTRANSFERASE (E2P)
分子名称:DIHYDROLIPOYL-TRANSACETYLASE
著者Hendle, J., Hol, W.G.J.
登録日1995-02-03
公開日1995-04-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystallographic and enzymatic investigations on the role of Ser558, His610, and Asn614 in the catalytic mechanism of Azotobacter vinelandii dihydrolipoamide acetyltransferase (E2p).
Biochemistry, 34, 1995
2WAZ
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N512P MUTANT OF THE DNA BINDING DOMAIN OF THE ADENOVIRUS 5 SSDNA BINDING PROTEIN
分子名称:E2A DNA-BINDING PROTEIN, ZINC ION
著者Hendle, J., Kanellopoulos, P.N., Tucker, P.A.
登録日2009-02-19
公開日2010-03-31
最終更新日2019-07-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献High Resolution Structures of the Adenovirus Single-Stranded DNA Binding Protein and the N512P Hinge-Region Mutant
To be Published
2WB0
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2.1 RESOLUTION STRUCTURE OF THE C-TERMINAL DOMAIN OF THE HUMAN ADENOVIRUS 5 SSDNA BINDING PROTEIN
分子名称:E2A DNA-BINDING PROTEIN, ZINC ION
著者Hendle, J., Kanellopoulos, P.N., Tucker, P.A.
登録日2009-02-19
公開日2010-03-31
最終更新日2019-07-24
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献High Resolution Structures of the Adenovirus Single-Stranded DNA Binding Protein and the N512P Hinge-Region Mutant
To be Published
6MNH
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ULK1 UNC-51 LIKE AUTOPHAGY ACTIVATING KINASE IN COMPLEX WITH INHIBITOR BTC
分子名称:Serine/threonine-protein kinase ULK1, N-[(2R)-3-methylbutan-2-yl]-1H-benzotriazole-6-carboxamide, DIMETHYL SULFOXIDE, ...
著者Hendle, J., Sauder, J.M., Hickey, M.J., Rauch, C.T., Maletic, M., Schwinn, K.D.
登録日2018-10-01
公開日2019-03-27
最終更新日2019-11-13
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Idea2Data: Toward a New Paradigm for Drug Discovery.
Acs Med.Chem.Lett., 10, 2019
1GPE
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GLUCOSE OXIDASE FROM PENICILLIUM AMAGASAKIENSE
分子名称:PROTEIN (GLUCOSE OXIDASE), N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
著者Hendle, J., Kalisz, H.M., Hecht, H.J.
登録日1999-03-24
公開日1999-05-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献1.8 and 1.9 A resolution structures of the Penicillium amagasakiense and Aspergillus niger glucose oxidases as a basis for modelling substrate complexes.
Acta Crystallogr.,Sect.D, 55, 1999
3CIZ
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CRYSTAL STRUCTURE OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE NS5B IN COMPLEX WITH SMALL MOLECULE FRAGMENTS
分子名称:RNA-directed RNA polymerase, ZINC ION, 2-amino-5-bromobenzoic acid
著者Hendle, j.
登録日2008-03-12
公開日2008-04-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors.
Bioorg.Med.Chem.Lett., 18, 2008
3CJ5
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CRYSTAL STRUCTURE OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE NS5B IN COMPLEX WITH OPTIMIZED SMALL MOLECULE FRAGMENTS
分子名称:RNA-directed RNA polymerase, N-(4-bromo-2-{[(3R,5S)-3,5-dimethylpiperidin-1-yl]carbonyl}phenyl)-4-morpholin-4-yl-4-oxobutanamide
著者Hendle, j.
登録日2008-03-12
公開日2008-04-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors.
Bioorg.Med.Chem.Lett., 18, 2008
3DKC
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STRUCTURE OF MET RECEPTOR TYROSINE KINASE IN COMPLEX WITH ATP
分子名称:Hepatocyte growth factor receptor, MAGNESIUM ION, CHLORIDE ION, ...
著者Hendle, J.
登録日2008-06-24
公開日2009-07-07
最終更新日2015-04-22
実験手法X-RAY DIFFRACTION (1.52 Å)
主引用文献SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo.
Mol.Cancer Ther., 8, 2009
3DKF
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STRUCTURE OF MET RECEPTOR TYROSINE KINASE IN COMPLEX WITH INHIBITOR SGX-523
分子名称:Hepatocyte growth factor receptor, CHLORIDE ION, 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline
著者Hendle, J.
登録日2008-06-24
公開日2009-07-07
最終更新日2015-04-22
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo.
Mol.Cancer Ther., 8, 2009
3DKG
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STRUCTURE OF MUTANT(Y1248L) MET RECEPTOR TYROSINE KINASE IN COMPLEX WITH INHIBITOR SGX-523
分子名称:Hepatocyte growth factor receptor, CHLORIDE ION, 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline
著者Hendle, J.
登録日2008-06-24
公開日2009-07-07
最終更新日2015-04-22
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo.
Mol.Cancer Ther., 8, 2009
5VR9
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CH1/CKAPPA FAB BASED ON MATUZUMAB
分子名称:CH1/Ckappa Fab heavy chain, CH1/Ckappa Fab light chain
著者Hendle, J.
登録日2017-05-10
公開日2017-08-02
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Computational design of a specific heavy chain/ kappa light chain interface for expressing fully IgG bispecific antibodies.
Protein Sci., 26, 2017
5VSH
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CH1/CLAMBDA FAB BASED ON PERTUZUMAB
分子名称:CH1/Clambda Fab heavy chain, CH1/Clambda Fab light chain, SULFATE ION
著者Hendle, J.
登録日2017-05-11
公開日2017-08-02
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Computational design of a specific heavy chain/ kappa light chain interface for expressing fully IgG bispecific antibodies.
Protein Sci., 26, 2017
5VSI
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CH1/CKAPPA FAB MUTANT 15.1
分子名称:CH1/Ckappa Fab heavy chain, CH1/Ckappa Fab light chain, SULFATE ION, ...
著者Hendle, J.
登録日2017-05-11
公開日2017-08-02
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Computational design of a specific heavy chain/ kappa light chain interface for expressing fully IgG bispecific antibodies.
Protein Sci., 26, 2017
1MDO
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CRYSTAL STRUCTURE OF ARNB AMINOTRANSFERASE WITH PYRIDOMINE 5' PHOSPHATE
分子名称:ArnB aminotransferase, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE
著者Noland, B.W., Newman, J.M., Hendle, J., Badger, J., Christopher, J.A., Tresser, J., Buchanan, M.D., Wright, T., Rutter, M.E., Sanderson, W.E., Muller-Dieckmann, H.-J., Gajiwala, K., Sauder, J.M., Buchanan, S.G.
登録日2002-08-07
公開日2002-12-11
最終更新日2018-12-26
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural studies of Salmonella typhimurium ArnB (PmrH) aminotransferase: A 4-amino-4-deoxy-L-arabinose lipopolysaccharide modifying enzyme
Structure, 10, 2002
1MDX
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CRYSTAL STRUCTURE OF ARNB TRANSFERASE WITH PYRIDOXAL 5' PHOSPHATE
分子名称:ArnB aminotransferase, PYRIDOXAL-5'-PHOSPHATE, 2-OXOGLUTARIC ACID, ...
著者Noland, B.W., Newman, J.M., Hendle, J., Badger, J., Christopher, J.A., Tresser, J., Buchanan, M.D., Wright, T.A., Rutter, M.E., Sanderson, W.E., Muller-Dieckmann, H.-J., Gajiwala, K.S., Sauder, J.M., Buchanan, S.G.
登録日2002-08-07
公開日2002-12-11
最終更新日2018-12-26
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Structural studies of Salmonella typhimurium ArnB (PmrH) aminotransferase: A 4-amino-4-deoxy-L-arabinose lipopolysaccharide modifying enzyme
Structure, 10, 2002
1MDZ
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CRYSTAL STRUCTURE OF ARNB AMINOTRANSFERASE WITH CYCLOSERINE AND PYRIDOXAL 5' PHOSPHATE
分子名称:ArnB aminotransferase, D-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-N,O-CYCLOSERYLAMIDE, PYRIDOXAL-5'-PHOSPHATE
著者Noland, B.W., Newman, J.M., Hendle, J., Badger, J., Christopher, J.A., Tresser, J., Buchanan, M.D., Wright, T., Rutter, M.E., Sanderson, W.E., Muller-Dieckmann, H.-J., Gajiwala, K.S., Sauder, J.M., Buchanan, S.G.
登録日2002-08-07
公開日2002-12-11
最終更新日2018-12-26
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Structural studies of Salmonella typhimurium ArnB (PmrH) aminotransferase: A 4-amino-4-deoxy-L-arabinose lipopolysaccharide modifying enzyme
Structure, 10, 2002
1XBA
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CRYSTAL STRUCTURE OF APO SYK TYROSINE KINASE DOMAIN
分子名称:Tyrosine-protein kinase SYK
著者Atwell, S., Adams, J.M., Badger, J., Buchanan, M.D., Feil, I.K., Froning, K.J., Gao, X., Hendle, J., Keegan, K., Leon, B.C., Muller-Deickmann, H.J., Nienaber, V.L., Noland, B.W., Post, K., Rajashankar, K.R., Ramos, A., Russell, M., Burley, S.K., Buchanan, S.G.
登録日2004-08-30
公開日2004-11-02
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase.
J.Biol.Chem., 279, 2004
1XBB
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CRYSTAL STRUCTURE OF THE SYK TYROSINE KINASE DOMAIN WITH GLEEVEC
分子名称:Tyrosine-protein kinase SYK, 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE
著者Nienaber, V.L., Atwell, S., Adams, J.M., Badger, J., Buchanan, M.D., Feil, I.K., Froning, K.J., Gao, X., Hendle, J., Keegan, K., Leon, B.C., Muller-Deickmann, H.J., Noland, B.W., Post, K., Rajashankar, K.R., Ramos, A., Russell, M., Burley, S.K., Buchanan, S.G.
登録日2004-08-30
公開日2004-11-02
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献A Novel Mode of Gleevec Binding Is Revealed by the Structure of Spleen Tyrosine Kinase
J.Biol.Chem., 279, 2004
1XBC
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CRYSTAL STRUCTURE OF THE SYK TYROSINE KINASE DOMAIN WITH STAUROSPORIN
分子名称:Tyrosine-protein kinase SYK, STAUROSPORINE
著者Badger, J., Atwell, S., Adams, J.M., Buchanan, M.D., Feil, I.K., Froning, K.J., Gao, X., Hendle, J., Keegan, K., Leon, B.C., Muller-Deickmann, H.J., Nienaber, V.L., Noland, B.W., Post, K., Rajashankar, K.R., Ramos, A., Russell, M., Burley, S.K., Buchanan, S.G.
登録日2004-08-30
公開日2004-11-02
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase
J.Biol.Chem., 279, 2004
1GAL
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CRYSTAL STRUCTURE OF GLUCOSE OXIDASE FROM ASPERGILLUS NIGER: REFINED AT 2.3 ANGSTROMS RESOLUTION
分子名称:GLUCOSE OXIDASE, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
著者Hecht, H.J., Kalisz, K., Hendle, J., Schmid, R.D., Schomburg, D.
登録日1992-08-27
公開日1993-10-31
最終更新日2019-08-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of glucose oxidase from Aspergillus niger refined at 2.3 A resolution.
J.Mol.Biol., 229, 1993
1Q2W
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X-RAY CRYSTAL STRUCTURE OF THE SARS CORONAVIRUS MAIN PROTEASE
分子名称:nonstructural polyprotein pp1a, (4S)-2-METHYL-2,4-PENTANEDIOL
著者Bonanno, J.B., Fowler, R., Gupta, S., Hendle, J., Lorimer, D., Romero, R., Sauder, J.M., Wei, C.L., Liu, E.T., Burley, S.K., Harris, T.
登録日2003-07-26
公開日2003-07-29
最終更新日2018-11-14
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献X-Ray Crystal Structure of the SARS Coronavirus Main Protease
To be Published
2PZE
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MINIMAL HUMAN CFTR FIRST NUCLEOTIDE BINDING DOMAIN AS A HEAD-TO-TAIL DIMER
分子名称:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
著者Atwell, S., Conners, K., Emtage, S., Gheyi, T., Glenn, N.R., Hendle, J., Lewis, H.A., Lu, F., Rodgers, L.A., Romero, R., Sauder, J.M., Smith, D., Tien, H., Wasserman, S.R., Zhao, X.
登録日2007-05-17
公開日2007-10-09
最終更新日2018-11-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010
2PZF
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MINIMAL HUMAN CFTR FIRST NUCLEOTIDE BINDING DOMAIN AS A HEAD-TO-TAIL DIMER WITH DELTA F508
分子名称:Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE
著者Atwell, S., Conners, K., Emtage, S., Gheyi, T., Glenn, N.R., Hendle, J., Lewis, H.A., Lu, F., Rodgers, L.A., Romero, R., Sauder, J.M., Smith, D., Tien, H., Wasserman, S.R., Zhao, X.
登録日2007-05-18
公開日2007-10-09
最終更新日2018-11-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant.
Protein Eng.Des.Sel., 23, 2010