7KMG

LY-CoV555 neutralizing antibody against SARS-CoV-2

Summary for 7KMG

• Entry DOI: 10.2210/pdb7kmg/pdb
• Descriptor: LY-CoV555 Fab heavy chain, LY-CoV555 Fab light chain, Spike protein S1, ... (5 entities in total)
• Functional Keywords: antibody neutralizing sars-cov-2, immune system, immune system-viral protein complex, immune system/viral protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 6
• Total formula weight: 142342.84

Authors

Hendle, J.,Pustilnik, A.,Sauder, J.M.,Coleman, K.A.,Boyles, J.S.,Dickinson, C.D. (deposition date: 2020-11-02, release date: 2021-01-27, Last modification date: 2023-10-18)

• Primary citation: Jones, B.E.,Brown-Augsburger, P.L.,Corbett, K.S.,Westendorf, K.,Davies, J.,Cujec, T.P.,Wiethoff, C.M.,Blackbourne, J.L.,Heinz, B.A.,Foster, D.,Higgs, R.E.,Balasubramaniam, D.,Wang, L.,Zhang, Y.,Yang, E.S.,Bidshahri, R.,Kraft, L.,Hwang, Y.,Zentelis, S.,Jepson, K.R.,Goya, R.,Smith, M.A.,Collins, D.W.,Hinshaw, S.J.,Tycho, S.A.,Pellacani, D.,Xiang, P.,Muthuraman, K.,Sobhanifar, S.,Piper, M.H.,Triana, F.J.,Hendle, J.,Pustilnik, A.,Adams, A.C.,Berens, S.J.,Baric, R.S.,Martinez, D.R.,Cross, R.W.,Geisbert, T.W.,Borisevich, V.,Abiona, O.,Belli, H.M.,de Vries, M.,Mohamed, A.,Dittmann, M.,Samanovic, M.I.,Mulligan, M.J.,Goldsmith, J.A.,Hsieh, C.L.,Johnson, N.V.,Wrapp, D.,McLellan, J.S.,Barnhart, B.C.,Graham, B.S.,Mascola, J.R.,Hansen, C.L.,Falconer, E.; The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates.; Sci Transl Med, 13:-, 2021; PubMed: 33820835; DOI: 10.1126/scitranslmed.abf1906

Experimental method

X-RAY DIFFRACTION (2.16 Å)