5VSH

CH1/Clambda Fab based on Pertuzumab

Summary for 5VSH

• Entry DOI: 10.2210/pdb5vsh/pdb
• Related: 5VR9 5VSI
• Descriptor: CH1/Clambda Fab heavy chain, CH1/Clambda Fab light chain, SULFATE ION, ... (4 entities in total)
• Functional Keywords: bispecific antibody, computational design, heavy chain/light chain interface, ch1/ckappa interface, pertuzumab, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 8
• Total formula weight: 188597.97

Authors

Hendle, J. (deposition date: 2017-05-11, release date: 2017-08-02, Last modification date: 2023-10-04)

• Primary citation: Froning, K.J.,Leaver-Fay, A.,Wu, X.,Phan, S.,Gao, L.,Huang, F.,Pustilnik, A.,Bacica, M.,Houlihan, K.,Chai, Q.,Fitchett, J.R.,Hendle, J.,Kuhlman, B.,Demarest, S.J.; Computational design of a specific heavy chain/ kappa light chain interface for expressing fully IgG bispecific antibodies.; Protein Sci., 26:2021-2038, 2017; PubMed: 28726352; DOI: 10.1002/pro.3240

Experimental method

X-RAY DIFFRACTION (2.55 Å)