6CXZ | | RNA OCTAMER CONTAINING 2'-F, 4'-CALPHA-ME U. | | Descriptor: | RNA (5'-R(*CP*GP*AP*AP*(U4M)P*UP*CP*G)-3'), CACODYLATE ION, COBALT HEXAMMINE(III) | | Authors: | Harp, J.M., Egli, M. | | Deposit date: | 2018-04-04 | | Release date: | 2018-08-29 | | Last modified: | 2018-10-03 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
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6CY0 | | RNA OCTAMER CONTAINING 2'-F, 4'-CBETA-OME U. | | Descriptor: | RNA (5'-R(*(CBV)P*GP*AP*AP*(UFB)P*UP*CP*G)-3') | | Authors: | Harp, J.M., Egli, M. | | Deposit date: | 2018-04-04 | | Release date: | 2018-08-29 | | Last modified: | 2018-10-03 | | Method: | X-RAY DIFFRACTION (2.398 Å) | | Cite: | Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
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6CY2 | | RNA OCTAMER CONTAINING 2'-OME, 4'CALPHA-OME U. | | Descriptor: | RNA (5'-R(*(CBV)P*GP*AP*AP*(UOA)P*UP*CP*G)-3') | | Authors: | Harp, J.M., Egli, M. | | Deposit date: | 2018-04-04 | | Release date: | 2018-08-29 | | Last modified: | 2018-10-03 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
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6CY4 | | RNA OCTAMER CONTAINING 2'-OME, 4'- CBETA-OME U. | | Descriptor: | RNA (5'-R(*(CBV)P*GP*AP*AP*(UOB)P*UP*CP*G)-3') | | Authors: | Harp, J.M., Egli, M. | | Deposit date: | 2018-04-04 | | Release date: | 2018-08-29 | | Last modified: | 2018-10-03 | | Method: | X-RAY DIFFRACTION (1.851 Å) | | Cite: | Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
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1EQZ | | X-RAY STRUCTURE OF THE NUCLEOSOME CORE PARTICLE AT 2.5 A RESOLUTION | | Descriptor: | 146 NUCLEOTIDES LONG DNA, PROTEIN (HISTONE H2A), PROTEIN (HISTONE H2B), ... | | Authors: | Hanson, B.L., Harp, J.M., Timm, D.E., Bunick, G.J. | | Deposit date: | 2000-04-06 | | Release date: | 2000-04-17 | | Last modified: | 2017-10-04 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Asymmetries in the nucleosome core particle at 2.5 A resolution.
Acta Crystallogr.,Sect.D, 56, 2000
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1MT6 | | STRUCTURE OF HISTONE H3 K4-SPECIFIC METHYLTRANSFERASE SET7/9 WITH ADOHCY | | Descriptor: | SET9, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Jacobs, S.A., Harp, J.M., Devarakonda, S., Kim, Y., Rastinejad, F., Khorasanizadeh, S. | | Deposit date: | 2002-09-20 | | Release date: | 2002-11-06 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The active site of the SET domain is constructed on a knot
Nat.Struct.Biol., 9, 2002
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1MUF | | STRUCTURE OF HISTONE H3 K4-SPECIFIC METHYLTRANSFERASE SET7/9 | | Descriptor: | SET9 | | Authors: | Jacobs, S.A., Harp, J.M., Devarakonda, S., Kim, Y., Rastinejad, F., Khorasanizadeh, S. | | Deposit date: | 2002-09-23 | | Release date: | 2002-11-06 | | Last modified: | 2011-11-16 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | The active site of the SET domain is constructed on a knot
Nat.Struct.Biol., 9, 2002
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1OSV | | STRUCTURAL BASIS FOR BILE ACID BINDING AND ACTIVATION OF THE NUCLEAR RECEPTOR FXR | | Descriptor: | Bile acid receptor, Nuclear receptor coactivator 2, 6-ETHYL-CHENODEOXYCHOLIC ACID | | Authors: | Mi, L.Z., Devarakonda, S., Harp, J.M., Han, Q., Pellicciari, R., Willson, T.M., Khorasanizadeh, S., Rastinejad, F. | | Deposit date: | 2003-03-20 | | Release date: | 2004-03-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR
Mol.Cell, 11, 2003
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1OT7 | | STRUCTURAL BASIS FOR 3-DEOXY-CDCA BINDING AND ACTIVATION OF FXR | | Descriptor: | Bile Acid Receptor, dodecamer peptide fragment of RPGR-interacting protein 1, 6-ETHYL-CHENODEOXYCHOLIC ACID, ... | | Authors: | Mi, L.Z., Devarakonda, S., Harp, J.M., Han, Q., Pellicciari, R., Willson, T.M., Khorasanizadeh, S., Rastinejad, F. | | Deposit date: | 2003-03-21 | | Release date: | 2004-03-23 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR
Mol.Cell, 11, 2003
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1QCN | | CRYSTAL STRUCTURE OF FUMARYLACETOACETATE HYDROLASE | | Descriptor: | FUMARYLACETOACETATE HYDROLASE, CALCIUM ION, ACETATE ION, ... | | Authors: | Timm, D.E., Mueller, H.A., Bhanumoorthy, P., Harp, J.M., Bunick, G.J. | | Deposit date: | 1999-05-14 | | Release date: | 2000-06-07 | | Last modified: | 2017-10-04 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure and mechanism of a carbon-carbon bond hydrolase.
Structure Fold.Des., 7, 1999
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1QCO | | CRYSTAL STRUCTURE OF FUMARYLACETOACETATE HYDROLASE COMPLEXED WITH FUMARATE AND ACETOACETATE | | Descriptor: | FUMARYLACETOACETATE HYDROLASE, CALCIUM ION, NICKEL (II) ION, ... | | Authors: | Timm, D.E., Mueller, H.A., Bhanumoorthy, P., Harp, J.M., Bunick, G.J. | | Deposit date: | 1999-05-17 | | Release date: | 2000-06-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure and mechanism of a carbon-carbon bond hydrolase.
Structure Fold.Des., 7, 1999
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1QQJ | | CRYSTAL STRUCTURE OF MOUSE FUMARYLACETOACETATE HYDROLASE REFINED AT 1.55 ANGSTROM RESOLUTION | | Descriptor: | FUMARYLACETOACETATE HYDROLASE, CALCIUM ION, ACETATE ION, ... | | Authors: | Timm, D.E., Mueller, H.A., Bhanumoorthy, P., Harp, J.M., Bunick, G.J. | | Deposit date: | 1999-06-07 | | Release date: | 2000-06-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Crystal structure and mechanism of a carbon-carbon bond hydrolase.
Structure Fold.Des., 7, 1999
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1R0N | | CRYSTAL STRUCTURE OF HETERODIMERIC ECDSYONE RECEPTOR DNA BINDING COMPLEX | | Descriptor: | Ecdsyone Response Element, Ecdysone Response Element, Retinoic acid receptor RXR-alpha, ... | | Authors: | Devarakonda, S., Harp, J.M., Kim, Y., Ozyhar, A., Rastinejad, F. | | Deposit date: | 2003-09-22 | | Release date: | 2003-10-21 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure of the heterodimeric Ecdysone Receptor DNA-binding complex
Embo J., 22, 2003
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1R0O | | CRYSTAL STRUCTURE OF THE HETERODIMERIC ECDYSONE RECEPTOR DNA-BINDING COMPLEX | | Descriptor: | Ecdysone Response Element, Ultraspiracle protein, Ecdysone receptor, ... | | Authors: | Devarakonda, S., Harp, J.M., Kim, Y., Ozyhar, A., Rastinejad, F. | | Deposit date: | 2003-09-22 | | Release date: | 2003-10-21 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | Structure of the Heterodimeric Ecdysone Receptor DNA-binding Complex
Embo J., 22, 2003
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3GX0 | | CRYSTAL STRUCTURE OF GSH-DEPENDENT DISULFIDE BOND OXIDOREDUCTASE | | Descriptor: | GST-like protein yfcG, OXIDIZED GLUTATHIONE DISULFIDE | | Authors: | Ladner, J.E., Harp, J.M., Wadington, M.C., Armstrong, R.N. | | Deposit date: | 2009-04-01 | | Release date: | 2009-07-07 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Analysis of the structure and function of YfcG from Escherichia coli reveals an efficient and unique disulfide bond reductase.
Biochemistry, 48, 2009
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3MF6 | | COMPUTATIONALLY DESIGNED ENDO-1,4-BETA-XYLANASE | | Descriptor: | Endo-1,4-beta-xylanase, SULFATE ION | | Authors: | Morin, A., Harp, J.M. | | Deposit date: | 2010-04-01 | | Release date: | 2010-11-10 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.28 Å) | | Cite: | Computational design of an endo-1,4-{beta}-xylanase ligand binding site.
Protein Eng.Des.Sel., 24, 2011
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3MF9 | | COMPUTATIONALLY DESIGNED ENDO-1,4-BETA-XYLANASE | | Descriptor: | Endo-1,4-beta-xylanase, SULFATE ION | | Authors: | Morin, A., Harp, J.M. | | Deposit date: | 2010-04-01 | | Release date: | 2010-11-10 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Computational design of an endo-1,4-{beta}-xylanase ligand binding site.
Protein Eng.Des.Sel., 24, 2011
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3MFA | | COMPUTATIONALLY DESIGNED ENDO-1,4-BETA-XYLANASE | | Descriptor: | Endo-1,4-beta-xylanase, SULFATE ION | | Authors: | Morin, A., Harp, J.M. | | Deposit date: | 2010-04-01 | | Release date: | 2010-11-10 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.63 Å) | | Cite: | Computational design of an endo-1,4-{beta}-xylanase ligand binding site.
Protein Eng.Des.Sel., 24, 2011
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3MFC | | COMPUTATIONALLY DESIGNED END0-1,4-BETA,XYLANASE | | Descriptor: | Endo-1,4-beta-xylanase, SULFATE ION | | Authors: | Morin, A., Harp, J.M. | | Deposit date: | 2010-04-01 | | Release date: | 2010-11-10 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Computational design of an endo-1,4-{beta}-xylanase ligand binding site.
Protein Eng.Des.Sel., 24, 2011
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3NT1 | | HIGH RESOLUTION STRUCTURE OF NAPROXEN:COX-2 COMPLEX. | | Descriptor: | Prostaglandin-endoperoxide synthase 2, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ... | | Authors: | Duggan, K.C., Musee, J., Walters, M.J., Harp, J.M., Kiefer, J.R., Oates, J.A., Marnett, L.J. | | Deposit date: | 2010-07-02 | | Release date: | 2010-09-01 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen.
J.Biol.Chem., 285, 2010
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3NTB | | STRUCTURE OF 6-METHYLTHIO NAPROXEN ANALOG BOUND TO MCOX-2. | | Descriptor: | Prostaglandin-endoperoxide synthase 2, PROTOPORPHYRIN IX CONTAINING FE, N-ACETYL-D-GLUCOSAMINE, ... | | Authors: | Duggan, K.C., Musee, J., Walters, M.J., Harp, J.M., Kiefer, J.R., Oates, J.A., Marnett, L.J. | | Deposit date: | 2010-07-03 | | Release date: | 2010-09-01 | | Last modified: | 2017-11-08 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen.
J.Biol.Chem., 285, 2010
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3R3E | | THE GLUTATHIONE BOUND STRUCTURE OF YQJG, A GLUTATHIONE TRANSFERASE HOMOLOG FROM ESCHERICHIA COLI K-12 | | Descriptor: | Uncharacterized protein yqjG, GLUTATHIONE, SULFATE ION | | Authors: | Branch, M.C., Cook, P.D., Harp, J.M., Armstrong, R.N. | | Deposit date: | 2011-03-15 | | Release date: | 2012-03-14 | | Method: | X-RAY DIFFRACTION (2.205 Å) | | Cite: | Crystal Structure Analysis of yqjG from Escherichia Coli K-12
To be Published
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4YP3 | | MUTANT HUMAN DNA POLYMERASE ETA Q38A/R61A INSERTING DCTP OPPOSITE AN 8-OXOGUANINE LESION | | Descriptor: | DNA polymerase eta, DNA (5'-D(*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | | Authors: | Su, Y., Patra, A., Harp, J.M., Egli, M., Guengerich, F.P. | | Deposit date: | 2015-03-12 | | Release date: | 2015-05-13 | | Last modified: | 2019-12-04 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290, 2015
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4YQW | | MUTANT HUMAN DNA POLYMERASE ETA Q38A/R61A INSERTING DCTP OPPOSITE TEMPLATE G | | Descriptor: | DNA polymerase eta, DNA (5'-D(*AP*TP*GP*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | | Authors: | Su, Y., Patra, A., Harp, J.M., Egli, M., Guengerich, F.P. | | Deposit date: | 2015-03-13 | | Release date: | 2015-05-13 | | Last modified: | 2019-12-04 | | Method: | X-RAY DIFFRACTION (2.064 Å) | | Cite: | Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290, 2015
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4YR0 | | MUTANT HUMAN DNA POLYMERASE ETA R61M INSERTING DCTP OPPOSITE AN 8-OXOGUANINE LESION | | Descriptor: | DNA polymerase eta, DNA (5'-D(P*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ... | | Authors: | Su, Y., Patra, A., Harp, J.M., Egli, M., Guengerich, F.P. | | Deposit date: | 2015-03-13 | | Release date: | 2015-05-13 | | Last modified: | 2019-12-04 | | Method: | X-RAY DIFFRACTION (1.78 Å) | | Cite: | Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290, 2015
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