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7UCR
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BU of 7ucr by Molmil
Joint X-ray/neutron structure of the Sarcin-Ricin loop RNA
Descriptor: SULFATE ION, Sarcin-Ricin loop RNA
Authors:Harp, J.M, Egli, M.E, Pallan, P.S, Coates, L.
Deposit date:2022-03-17
Release date:2022-07-20
Last modified:2024-04-03
Method:NEUTRON DIFFRACTION (1 Å), X-RAY DIFFRACTION
Cite:Cryo neutron crystallography demonstrates influence of RNA 2'-OH orientation on conformation, sugar pucker and water structure.
Nucleic Acids Res., 50, 2022
7JY2
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BU of 7jy2 by Molmil
Z-DNA joint X-ray/Neutron
Descriptor: Chains: A,B
Authors:Harp, J.M, Coates, L, Egli, M.
Deposit date:2020-08-28
Release date:2021-04-28
Last modified:2024-04-03
Method:NEUTRON DIFFRACTION (1.5 Å), X-RAY DIFFRACTION
Cite:Water structure around a left-handed Z-DNA fragment analyzed by cryo neutron crystallography.
Nucleic Acids Res., 49, 2021
6CY2
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BU of 6cy2 by Molmil
RNA octamer containing 2'-OMe, 4'Calpha-OMe U.
Descriptor: RNA (5'-R(*(CBV)P*GP*AP*AP*(UOA)P*UP*CP*G)-3')
Authors:Harp, J.M, Egli, M.
Deposit date:2018-04-04
Release date:2018-08-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
6CXZ
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BU of 6cxz by Molmil
RNA octamer containing 2'-F, 4'-Calpha-Me U.
Descriptor: CACODYLATE ION, COBALT HEXAMMINE(III), RNA (5'-R(*CP*GP*AP*AP*(U4M)P*UP*CP*G)-3')
Authors:Harp, J.M, Egli, M.
Deposit date:2018-04-04
Release date:2018-08-29
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
6CY4
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BU of 6cy4 by Molmil
RNA octamer containing 2'-OMe, 4'- Cbeta-OMe U.
Descriptor: RNA (5'-R(*(CBV)P*GP*AP*AP*(UOB)P*UP*CP*G)-3')
Authors:Harp, J.M, Egli, M.
Deposit date:2018-04-04
Release date:2018-08-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.851 Å)
Cite:Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
6CY0
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BU of 6cy0 by Molmil
RNA octamer containing 2'-F, 4'-Cbeta-OMe U.
Descriptor: RNA (5'-R(*(CBV)P*GP*AP*AP*(UFB)P*UP*CP*G)-3')
Authors:Harp, J.M, Egli, M.
Deposit date:2018-04-04
Release date:2018-08-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.398 Å)
Cite:Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
9BF0
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BU of 9bf0 by Molmil
MID domain of human Argo2 bound to UTP
Descriptor: Protein argonaute-2, URIDINE 5'-TRIPHOSPHATE
Authors:Harp, J.M, Egli, M.
Deposit date:2024-04-16
Release date:2024-07-10
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth.
Curr Protoc, 4, 2024
9BF2
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BU of 9bf2 by Molmil
MID domain of Ago2 bound to UMP
Descriptor: Protein argonaute-2, URIDINE-5'-MONOPHOSPHATE
Authors:Harp, J.M, Egli, M.
Deposit date:2024-04-16
Release date:2024-07-10
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth.
Curr Protoc, 4, 2024
9BEZ
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BU of 9bez by Molmil
MID domain of human Argo2 bound to RNA
Descriptor: Protein argonaute-2, [(3~{S},4~{R},5~{R})-5-[5-methyl-2,4-bis(oxidanylidene)pyrimidin-1-yl]-4-oxidanyl-oxolan-3-yl] [oxidanyl(phosphonooxy)phosphoryl] hydrogen phosphate
Authors:Harp, J.M, Egli, M.
Deposit date:2024-04-16
Release date:2024-07-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and Stability of Ago2 MID-Nucleotide Complexes: All-in-One (Drop) His 6 -SUMO Tag Removal, Nucleotide Binding, and Crystal Growth.
Curr Protoc, 4, 2024
1EQZ
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BU of 1eqz by Molmil
X-RAY STRUCTURE OF THE NUCLEOSOME CORE PARTICLE AT 2.5 A RESOLUTION
Descriptor: 146 NUCLEOTIDES LONG DNA, CACODYLATE ION, CHLORIDE ION, ...
Authors:Hanson, B.L, Harp, J.M, Timm, D.E, Bunick, G.J.
Deposit date:2000-04-06
Release date:2000-04-17
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Asymmetries in the nucleosome core particle at 2.5 A resolution.
Acta Crystallogr.,Sect.D, 56, 2000
7JJF
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BU of 7jjf by Molmil
Sarcin-ricin loop with modified residue.
Descriptor: MAGNESIUM ION, RNA/DNA (27-mer)
Authors:Harp, J.M, Pallan, P.S, Egli, M.
Deposit date:2020-07-25
Release date:2020-12-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Incorporating a Thiophosphate Modification into a Common RNA Tetraloop Motif Causes an Unanticipated Stability Boost.
Biochemistry, 59, 2020
8SKQ
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BU of 8skq by Molmil
RNA oligonucleotide containing an alpha-(L)-threofuranosyl nucleic acid (TNA)
Descriptor: TNA-containing RNA oligonucleotide
Authors:Harp, J.M, Egli, M.
Deposit date:2023-04-20
Release date:2024-02-14
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Shorter Is Better: The alpha-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs.
J.Am.Chem.Soc., 145, 2023
7LO9
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BU of 7lo9 by Molmil
RNA dodecamer containing a GNA A residue
Descriptor: Chains: A,B,C,D
Authors:Harp, J.M, Wawrzak, Z, Egli, M.
Deposit date:2021-02-09
Release date:2021-12-22
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs.
Nucleic Acids Res., 49, 2021
9O9N
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BU of 9o9n by Molmil
Crystal structure of PPARgamma ligand binding domain (LBD) in complex with NCoR1 corepressor peptide and inverse agonist FX-909
Descriptor: (3P)-3-(5,7-difluoro-4-oxo-1,4-dihydroquinolin-2-yl)-4-(methanesulfonyl)benzonitrile, Nuclear receptor corepressor 1, Peroxisome proliferator-activated receptor gamma
Authors:Laughlin, Z.T, Dong, J, Harp, J.M, Kojetin, D.J.
Deposit date:2025-04-18
Release date:2025-05-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of PPARgamma-mediated transcriptional repression by the covalent inverse agonist FX-909
To Be Published
8FTJ
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BU of 8ftj by Molmil
Crystal structure of human NEIL1 (P2G (242K) C(delta)100) glycosylase bound to DNA duplex containing urea
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*CP*GP*TP*CP*CP*AP*UDV*GP*TP*CP*TP*AP*CP)-3'), DNA (5'-D(*TP*AP*GP*AP*CP*AP*TP*GP*GP*AP*CP*GP*G)-3'), ...
Authors:Tomar, R, Sharma, P, Harp, J.M, Egli, M, Stone, M.P.
Deposit date:2023-01-12
Release date:2023-04-26
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Base excision repair of the N-(2-deoxy-d-erythro-pentofuranosyl)-urea lesion by the hNEIL1 glycosylase.
Nucleic Acids Res., 51, 2023
3R3E
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BU of 3r3e by Molmil
The glutathione bound structure of YqjG, a glutathione transferase homolog from Escherichia coli K-12
Descriptor: GLUTATHIONE, SULFATE ION, Uncharacterized protein yqjG
Authors:Branch, M.C, Cook, P.D, Harp, J.M, Armstrong, R.N.
Deposit date:2011-03-15
Release date:2012-03-14
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.205 Å)
Cite:Crystal Structure Analysis of yqjG from Escherichia Coli K-12
To be Published
7JJE
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BU of 7jje by Molmil
Sarcin-ricin loop with guanosine dithiophosphate residue.
Descriptor: RNA (27-MER)
Authors:Pallan, P.S, Egli, M, Harp, J.M.
Deposit date:2020-07-25
Release date:2020-12-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Incorporating a Thiophosphate Modification into a Common RNA Tetraloop Motif Causes an Unanticipated Stability Boost.
Biochemistry, 59, 2020
7JJD
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BU of 7jjd by Molmil
Sarcin-ricin loop with guanosine monothiophosphate residue.
Descriptor: RNA (27-MER)
Authors:Pallan, P.S, Egli, M, Harp, J.M.
Deposit date:2020-07-25
Release date:2020-12-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:Incorporating a Thiophosphate Modification into a Common RNA Tetraloop Motif Causes an Unanticipated Stability Boost.
Biochemistry, 59, 2020
8THQ
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BU of 8thq by Molmil
Nonamer RNA bound to hAgo2-PAZ
Descriptor: Protein argonaute-2, RNA (5'-R(*CP*GP*UP*GP*AP*CP*UP*CP*U)-3')
Authors:Pallan, P.S, Harp, J.M, Egli, M.
Deposit date:2023-07-17
Release date:2024-10-16
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Single-Stranded Hairpin Loop RNAs (loopmeRNAs) Potently Induce Gene Silencing through the RNA Interference Pathway.
J.Am.Chem.Soc., 2024
7L5M
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BU of 7l5m by Molmil
Crystal Structure of the DiB-RM-split Protein
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Lipocalin family protein, SODIUM ION, ...
Authors:Bozhanova, N.G, Harp, J.M, Meiler, J.
Deposit date:2020-12-22
Release date:2021-10-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Computational redesign of a fluorogen activating protein with Rosetta.
Plos Comput.Biol., 17, 2021
7L5L
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BU of 7l5l by Molmil
Crystal structure of the DiB-RM protein
Descriptor: Lipocalin family protein, SULFATE ION
Authors:Bozhanova, N.G, Harp, J.M, Meiler, J.
Deposit date:2020-12-22
Release date:2021-10-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Computational redesign of a fluorogen activating protein with Rosetta.
Plos Comput.Biol., 17, 2021
7L5K
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BU of 7l5k by Molmil
Crystal structure of the DiB-RM protein
Descriptor: DODECYL-BETA-D-MALTOSIDE, ISOPROPYL ALCOHOL, Lipocalin family protein, ...
Authors:Bozhanova, N.G, Harp, J.M, Meiler, J.
Deposit date:2020-12-22
Release date:2021-10-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Computational redesign of a fluorogen activating protein with Rosetta.
Plos Comput.Biol., 17, 2021
4YQW
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BU of 4yqw by Molmil
Mutant Human DNA Polymerase Eta Q38A/R61A Inserting dCTP Opposite Template G
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Su, Y, Patra, A, Harp, J.M, Egli, M, Guengerich, F.P.
Deposit date:2015-03-13
Release date:2015-05-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.064 Å)
Cite:Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290, 2015
4YR3
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BU of 4yr3 by Molmil
Mutant Human DNA Polymerase Eta R61M Inserting dCTP Opposite Template G
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Su, Y, Patra, A, Harp, J.M, Egli, M, Guengerich, F.P.
Deposit date:2015-03-14
Release date:2015-05-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290, 2015
4YR2
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BU of 4yr2 by Molmil
Mutant Human DNA Polymerase Eta R61M Inserting dATP Opposite an 8-Oxoguanine Lesion
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Su, Y, Patra, A, Harp, J.M, Egli, M, Guengerich, F.P.
Deposit date:2015-03-14
Release date:2015-05-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290, 2015

 

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