9O9N

Crystal structure of PPARgamma ligand binding domain (LBD) in complex with NCoR1 corepressor peptide and inverse agonist FX-909

This is a non-PDB format compatible entry.

Summary for 9O9N

• Entry DOI: 10.2210/pdb9o9n/pdb
• Descriptor: Peroxisome proliferator-activated receptor gamma, Nuclear receptor corepressor 1, (3P)-3-(5,7-difluoro-4-oxo-1,4-dihydroquinolin-2-yl)-4-(methanesulfonyl)benzonitrile, ... (4 entities in total)
• Functional Keywords: nuclear, receptor, inverse agonist, cancer, fx-909, ppar, pparg, ncor, corepressor, nuclear protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 34375.73

Authors

Laughlin, Z.T.,Dong, J.,Harp, J.M.,Kojetin, D.J. (deposition date: 2025-04-18, release date: 2025-05-14)

• Primary citation: Laughlin, Z.T.,Arifova, L.,Munoz-Tello, P.,Yu, X.,Dong, J.,Harp, J.M.,Kojetin, D.J.; Structural basis of PPARgamma-mediated transcriptional repression by the covalent inverse agonist FX-909; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)