Author results

1F82
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BOTULINUM NEUROTOXIN TYPE B CATALYTIC DOMAIN
Descriptor:BOTULINUM NEUROTOXIN TYPE B, ZINC ION
Authors:Hanson, M.A., Stevens, R.C.
Deposit date:2000-06-28
Release date:2000-08-16
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 A resolution.
Nat.Struct.Biol., 7, 2000
3D4S
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CHOLESTEROL BOUND FORM OF HUMAN BETA2 ADRENERGIC RECEPTOR.
Descriptor:Beta-2 adrenergic receptor/T4-lysozyme chimera, (2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol, CHOLESTEROL, ...
Authors:Hanson, M.A., Cherezov, V., Roth, C.B., Griffith, M.T., Jaakola, V.-P., Chien, E.Y.T., Velasquez, J., Kuhn, P., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2008-05-14
Release date:2008-06-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor.
Structure, 16, 2008
3V2W
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CRYSTAL STRUCTURE OF A LIPID G PROTEIN-COUPLED RECEPTOR AT 3.35A
Descriptor:Sphingosine 1-phosphate receptor 1, Lysozyme chimera, {(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl}phosphonic acid, ...
Authors:Hanson, M.A., Roth, C.B., Jo, E., Griffith, M.T., Scott, F.L., Reinhart, G., Desale, H., Clemons, B., Cahalan, S.M., Schuerer, S.C., Sanna, M.G., Han, G.W., Kuhn, P., Rosen, H., Stevens, R.C., GPCR Network (GPCR)
Deposit date:2011-12-12
Release date:2012-02-15
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Crystal structure of a lipid G protein-coupled receptor.
Science, 335, 2012
3V2Y
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CRYSTAL STRUCTURE OF A LIPID G PROTEIN-COUPLED RECEPTOR AT 2.80A
Descriptor:Sphingosine 1-phosphate receptor 1, Lysozyme chimera (E.C.3.2.1.17), {(3R)-3-amino-4-[(3-hexylphenyl)amino]-4-oxobutyl}phosphonic acid, ...
Authors:Hanson, M.A., Roth, C.B., Jo, E., Griffith, M.T., Scott, F.L., Reinhart, G., Desale, H., Clemons, B., Cahalan, S.M., Schuerer, S.C., Sanna, M.G., Han, G.W., Kuhn, P., Rosen, H., Stevens, R.C., GPCR Network (GPCR)
Deposit date:2011-12-12
Release date:2012-02-15
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of a lipid G protein-coupled receptor.
Science, 335, 2012
2RH1
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HIGH RESOLUTION CRYSTAL STRUCTURE OF HUMAN B2-ADRENERGIC G PROTEIN-COUPLED RECEPTOR.
Descriptor:beta-2-adrenergic receptor/T4-lysozyme chimera, MALTOSE, SULFATE ION, ...
Authors:Cherezov, V., Rosenbaum, D.M., Hanson, M.A., Rasmussen, S.G.F., Thian, F.S., Kobilka, T.S., Choi, H.J., Kuhn, P., Weis, W.I., Kobilka, B.K., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2007-10-05
Release date:2007-10-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.
Science, 318, 2007
1D5B
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UNLIGANDED MATURE OXY-COPE CATALYTIC ANTIBODY
Descriptor:chimeric OXY-COPE catalytic ANTIBODY AZ-28 (light chain), chimeric OXY-COPE catalytic ANTIBODY AZ-28 (HEAVY chain), CADMIUM ION
Authors:Mundorff, E.C., Hanson, M.A., Schultz, P.G., Stevens, R.C.
Deposit date:1999-10-06
Release date:2000-02-09
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Conformational effects in biological catalysis: an antibody-catalyzed oxy-cope rearrangement.
Biochemistry, 39, 2000
1D5I
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UNLIGANDED GERMLINE PRECURSOR OF AN OXY-COPE CATALYTIC ANTIBODY
Descriptor:CHIMERIC GERMLINE PRECURSOR OF OXY-COPE CATALYTIC ANTIBODY AZ-28 (LIGHT CHAIN), CHIMERIC GERMLINE PRECURSOR OF OXY-COPE CATALYTIC ANTIBODY AZ-28 (HEAVY CHAIN), CADMIUM ION
Authors:Mundorff, E.C., Hanson, M.A., Schultz, P.G., Stevens, R.C.
Deposit date:1999-10-07
Release date:2000-02-09
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Conformational effects in biological catalysis: an antibody-catalyzed oxy-cope rearrangement.
Biochemistry, 39, 2000
1D6V
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CONFORMATION EFFECTS IN BIOLOGICAL CATALYSIS INTRODUCED BY OXY-COPE ANTIBODY MATURATION
Descriptor:CHIMERIC GERMLINE PRECURSOR OF OXY-COPE CATALYTIC ANTIBODY AZ-28 (LIGHT CHAIN), CHIMERIC GERMLINE PRECURSOR OF OXY-COPE CATALYTIC ANTIBODY AZ-28 (HEAVY CHAIN), CADMIUM ION, ...
Authors:Mundorff, E.C., Hanson, M.A., Schultz, P.G., Stevens, R.C.
Deposit date:1999-10-15
Release date:2000-02-09
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Conformational effects in biological catalysis: an antibody-catalyzed oxy-cope rearrangement.
Biochemistry, 39, 2000
1MT5
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CRYSTAL STRUCTURE OF FATTY ACID AMIDE HYDROLASE
Descriptor:Fatty-acid amide hydrolase, METHYL ARACHIDONYL FLUOROPHOSPHONATE
Authors:Bracey, M.H., Hanson, M.A., Masuda, K.R., Stevens, R.C., Cravatt, B.F.
Deposit date:2002-09-20
Release date:2002-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Adaptations in a Membrane Enzyme That Terminates Endocannabinoid Signaling
science, 298, 2002
3EML
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THE 2.6 A CRYSTAL STRUCTURE OF A HUMAN A2A ADENOSINE RECEPTOR BOUND TO ZM241385.
Descriptor:Human Adenosine A2A receptor/T4 lysozyme chimera, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, STEARIC ACID, ...
Authors:Jaakola, V.-P., Griffith, M.T., Hanson, M.A., Cherezov, V., Chien, E.Y.T., Lane, J.R., Ijzerman, A.P., Stevens, R.C., Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR)
Deposit date:2008-09-24
Release date:2008-10-14
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist.
Science, 322, 2008
4Z34
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CRYSTAL STRUCTURE OF HUMAN LYSOPHOSPHATIDIC ACID RECEPTOR 1 IN COMPLEX WITH ONO9780307
Descriptor:Lysophosphatidic acid receptor 1, Soluble cytochrome b562, {1-[(2S,3S)-2-(2,3-dihydro-1H-inden-2-ylmethyl)-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-4-(methoxycarbonyl)-1H-pyrrol-3-yl}acetic acid, ...
Authors:Chrencik, J.E., Roth, C.B., Terakado, M., Kurata, H., Omi, R., Kihara, Y., Warshaviak, D., Nakade, S., Asmar-Rovira, G., Mileni, M., Mizuno, H., Griffith, M.T., Rodgers, C., Han, G.W., Velasquez, J., Chun, J., Stevens, R.C., Hanson, M.A., GPCR Network (GPCR)
Deposit date:2015-03-30
Release date:2015-06-03
Last modified:2015-07-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1.
Cell, 161, 2015
4Z35
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CRYSTAL STRUCTURE OF HUMAN LYSOPHOSPHATIDIC ACID RECEPTOR 1 IN COMPLEX WITH ONO-9910539
Descriptor:Lysophosphatidic acid receptor 1,Soluble cytochrome b562, 3-{1-[(2S,3S)-3-(4-acetyl-3,5-dimethoxyphenyl)-2-(2,3-dihydro-1H-inden-2-ylmethyl)-3-hydroxypropyl]-4-(methoxycarbonyl)-1H-pyrrol-3-yl}propanoic acid, (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate
Authors:Chrencik, J.E., Roth, C.B., Terakado, M., Kurata, H., Omi, R., Kihara, Y., Warshaviak, D., Nakade, S., Asmar-Rovira, G., Mileni, M., Mizuno, H., Griffith, M.T., Rodgers, C., Han, G.W., Velasquez, J., Chun, J., Stevens, R.C., Hanson, M.A., GPCR Network (GPCR)
Deposit date:2015-03-30
Release date:2015-06-03
Last modified:2015-07-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1.
Cell, 161, 2015
4Z36
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CRYSTAL STRUCTURE OF HUMAN LYSOPHOSPHATIDIC ACID RECEPTOR 1 IN COMPLEX WITH ONO-3080573
Descriptor:Lysophosphatidic acid receptor 1,Soluble cytochrome b562, 1-(4-{[(2S,3R)-2-(2,3-dihydro-1H-inden-2-yloxy)-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]oxy}phenyl)cyclopropanecarboxylic acid, (2S)-2,3-dihydroxypropyl (7Z)-tetradec-7-enoate
Authors:Chrencik, J.E., Roth, C.B., Terakado, M., Kurata, H., Omi, R., Kihara, Y., Warshaviak, D., Nakade, S., Asmar-Rovira, G., Mileni, M., Mizuno, H., Griffith, M.T., Rodgers, C., Han, G.W., Velasquez, J., Chun, J., Stevens, R.C., Hanson, M.A., GPCR Network (GPCR)
Deposit date:2015-03-30
Release date:2015-06-03
Last modified:2015-07-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1.
Cell, 161, 2015
5TGZ
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CRYSTAL STRUCTURE OF THE HUMAN CANNABINOID RECEPTOR CB1
Descriptor:Cannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1, 4-[4-[2-(2,4-dichlorophenyl)-4-methyl-5-(piperidin-1-ylcarbamoyl)pyrazol-3-yl]phenyl]but-3-ynyl nitrate, FLAVIN MONONUCLEOTIDE, ...
Authors:Hua, T., Vemuri, K., Pu, M., Qu, L., Han, G.W., Wu, Y., Zhao, S., Shui, W., Li, S., Korde, A., Laprairie, R.B., Stahl, E.L., Ho, J-H., Zvonok, N., Zhou, H., Kufareva, I., Wu, B., Zhao, Q., Hanson, M.A., Bohn, L.M., Makriyannis, A., Stevens, R.C., Liu, Z-J.
Deposit date:2016-09-28
Release date:2016-11-02
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the Human Cannabinoid Receptor CB1.
Cell, 167, 2016
5V56
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2.9A XFEL STRUCTURE OF THE MULTI-DOMAIN HUMAN SMOOTHENED RECEPTOR (WITH E194M MUTATION) IN COMPLEX WITH TC114
Descriptor:Smoothened homolog,Flavodoxin,Smoothened homolog, N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-4-nitro-2-(trifluoromethyl)benzamide, FLAVIN MONONUCLEOTIDE, ...
Authors:Zhang, X., Zhao, F., Wu, Y., Yang, J., Han, G.W., Zhao, S., Ishchenko, A., Ye, L., Lin, X., Ding, K., Dharmarajan, V., Griffin, P.R., Gati, C., Nelson, G., Hunter, M.S., Hanson, M.A., Cherezov, V., Stevens, R.C., Tan, W., Tao, H., Xu, F.
Deposit date:2017-03-13
Release date:2017-05-24
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand.
Nat Commun, 8, 2017
5V57
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3.0A SYN STRUCTURE OF THE MULTI-DOMAIN HUMAN SMOOTHENED RECEPTOR IN COMPLEX WITH TC114
Descriptor:Smoothened homolog,Flavodoxin,Smoothened homolog, N-methyl-N-[1-[4-(2-methylpyrazol-3-yl)phthalazin-1-yl]piperidin-4-yl]-4-nitro-2-(trifluoromethyl)benzamide, FLAVIN MONONUCLEOTIDE, ...
Authors:Zhang, X., Zhao, F., Wu, Y., Yang, J., Han, G.W., Zhao, S., Ishchenko, A., Ye, L., Lin, X., Ding, K., Dharmarajan, V., Griffin, P.R., Gati, C., Nelson, G., Hunter, M.S., Hanson, M.A., Cherezov, V., Stevens, R.C., Tan, W., Tao, H., Xu, F.
Deposit date:2017-03-13
Release date:2017-05-24
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand.
Nat Commun, 8, 2017
5VBL
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STRUCTURE OF APELIN RECEPTOR IN COMPLEX WITH AGONIST PEPTIDE
Descriptor:agonist peptide, Apelin receptor,Rubredoxin,Apelin receptor Chimera, ZINC ION, ...
Authors:Ma, Y., Yue, Y., Ma, Y., Zhang, Q., Zhou, Q., Song, Y., Shen, Y., Li, X., Ma, X., Li, C., Hanson, M.A., Han, G.W., Sickmier, E.A., Swaminath, G., Zhao, S., Stevems, R.C., Hu, L.A., Zhong, W., Zhang, M., Xu, F.
Deposit date:2017-03-29
Release date:2017-05-31
Last modified:2017-07-19
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Basis for Apelin Control of the Human Apelin Receptor
Structure, 25, 2017
5VEW
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STRUCTURE OF THE HUMAN GLP-1 RECEPTOR COMPLEX WITH PF-06372222
Descriptor:Glucagon-like peptide 1 receptor,Endolysin chimera, N-{4-[(R)-(3,3-dimethylcyclobutyl)({6-[4-(trifluoromethyl)-1H-imidazol-1-yl]pyridin-3-yl}amino)methyl]benzene-1-carbonyl}-beta-alanine, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Song, G., Yang, D., Wang, Y., Graaf, C.D., Zhou, Q., Jiang, S., Liu, K., Cai, X., Dai, A., Lin, G., Liu, D., Wu, F., Wu, Y., Zhao, S., Ye, L., Han, G.W., Lau, J., Wu, B., Hanson, M.A., Liu, Z.-J., Wang, M.-W., Stevens, R.C.
Deposit date:2017-04-05
Release date:2017-05-24
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.
Nature, 546, 2017
5VEX
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STRUCTURE OF THE HUMAN GLP-1 RECEPTOR COMPLEX WITH NNC0640
Descriptor:Glucagon-like peptide 1 receptor, Endolysin chimera, 4-{[(4-cyclohexylphenyl){[3-(methylsulfonyl)phenyl]carbamoyl}amino]methyl}-N-(1H-tetrazol-5-yl)benzamide
Authors:Song, G., Yang, D., Wang, Y., Graaf, C.D., Zhou, Q., Jiang, S., Liu, K., Cai, X., Dai, A., Lin, G., Liu, D., Wu, F., Wu, Y., Zhao, S., Ye, L., Han, G.W., Lau, J., Wu, B., Hanson, M.A., Liu, Z.-J., Wang, M.-W., Stevens, R.C.
Deposit date:2017-04-05
Release date:2017-05-17
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.
Nature, 546, 2017
5XR8
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CRYSTAL STRUCTURE OF THE HUMAN CB1 IN COMPLEX WITH AGONIST AM841
Descriptor:Cannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1, FLAVIN MONONUCLEOTIDE, (6aR,9R,10aR)-3-(8-azanyl-2-methyl-octan-2-yl)-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol, ...
Authors:Hua, T., Vemuri, K., Nikas, P.S., Laprairie, R.B., Wu, Y., Qu, L., Pu, M., Korde, A., Shan, J., Ho, J.H., Han, G.W., Ding, K., Li, X., Liu, H., Hanson, M.A., Zhao, S., Bohn, L.M., Makriyannis, A., Stevens, R.C., Liu, Z.J.
Deposit date:2017-06-07
Release date:2017-07-12
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal structures of agonist-bound human cannabinoid receptor CB1
Nature, 547, 2017
5XRA
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CRYSTAL STRUCTURE OF THE HUMAN CB1 IN COMPLEX WITH AGONIST AM11542
Descriptor:Cannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1, FLAVIN MONONUCLEOTIDE, (6aR,10aR)-3-(8-bromanyl-2-methyl-octan-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol, ...
Authors:Hua, T., Vemuri, K., Nikas, P.S., Laprairie, R.B., Wu, Y., Qu, L., Pu, M., Korde, A., Shan, J., Ho, J.H., Han, G.W., Ding, K., Li, X., Liu, H., Hanson, M.A., Zhao, S., Bohn, L.M., Makriyannis, A., Stevens, R.C., Liu, Z.J.
Deposit date:2017-06-08
Release date:2017-07-12
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of agonist-bound human cannabinoid receptor CB1
Nature, 547, 2017
6BQG
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CRYSTAL STRUCTURE OF 5-HT2C IN COMPLEX WITH ERGOTAMINE
Descriptor:5-hydroxytryptamine receptor 2C,Soluble cytochrome b562, Ergotamine, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
Authors:Peng, Y., McCorvy, J.D., Harpsoe, K., Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajse, L.F., Huang, X.P., Wu, Y., Shen, L., Bjorn-Yoshimoto, W.E., Ding, K., Wacker, D., Han, G.W., Cheng, J., Katritch, V., Jensen, A.A., Hanson, M.A., Zhao, S., Gloriam, D.E., Roth, B.L., Stevens, R.C., Liu, Z.
Deposit date:2017-11-27
Release date:2018-02-14
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.
Cell, 172, 2018
6BQH
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CRYSTAL STRUCTURE OF 5-HT2C IN COMPLEX WITH RITANSERIN
Descriptor:5-hydroxytryptamine receptor 2C,Soluble cytochrome b562, 6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Peng, Y., McCorvy, J.D., Harpsoe, K., Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajse, L.F., Huang, X.P., Wu, Y., Shen, L., Bjorn-Yoshimoto, W.E., Ding, K., Wacker, D., Han, G.W., Cheng, J., Katritch, V., Jensen, A.A., Hanson, M.A., Zhao, S., Gloriam, D.E., Roth, B.L., Stevens, R.C., Liu, Z.
Deposit date:2017-11-27
Release date:2018-02-14
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.
Cell, 172, 2018
6M9T
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CRYSTAL STRUCTURE OF EP3 RECEPTOR BOUND TO MISOPROSTOL-FA
Descriptor:Prostaglandin E2 receptor EP3 subtype, Endolysin chimera, (11alpha,12alpha,13E,16S)-11,16-dihydroxy-16-methyl-9-oxoprost-13-en-1-oic acid, ...
Authors:Audet, M., White, K.L., Breton, B., Zarzycka, B., Han, G.W., Lu, Y., Gati, C., Batyuk, A., Popov, P., Velasquez, J., Manahan, D., Hu, H., Weierstall, U., Liu, W., Shui, W., Katrich, V., Cherezov, V., Hanson, M.A., Stevens, R.C.
Deposit date:2018-08-24
Release date:2018-12-05
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of misoprostol bound to the labor inducer prostaglandin E2receptor.
Nat. Chem. Biol., 15, 2019
1YBI
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CRYSTAL STRUCTURE OF HA33A, A NEUROTOXIN-ASSOCIATED PROTEIN FROM CLOSTRIDIUM BOTULINUM TYPE A
Descriptor:non-toxin haemagglutinin HA34
Authors:Arndt, J.W., Gu, J., Jaroszewski, L., Schwarzenbacher, R., Hanson, M., Lebeda, F.J., Stevens, R.C.
Deposit date:2004-12-20
Release date:2005-02-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The Structure of the Neurotoxin-associated Protein HA33/A from Clostridium botulinum Suggests a Reoccurring beta-Trefoil Fold in the Progenitor Toxin Complex.
J.Mol.Biol., 346, 2005
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