Author results

4IN9
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STRUCTURE OF KARILYSIN MMP-LIKE CATALYTIC DOMAIN IN COMPLEX WITH INHIBITORY TETRAPEPTIDE SWFP
Descriptor:Karilysin protease, Peptide SER-TRP-PHE-PRO, ZINC ION, ...
Authors:Guevara, T., Ksiazek, M., Skottrup, P.D., Cerda-Costa, N., Trillo-Muyo, S., de Diego, I., Riise, E., Potempa, J., Gomis-Ruth, F.X.
Deposit date:2013-01-04
Release date:2013-05-15
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure of the catalytic domain of the Tannerella forsythia matrix metallopeptidase karilysin in complex with a tetrapeptidic inhibitor.
Acta Crystallogr.,Sect.F, 69, 2013
2IWA
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UNBOUND GLUTAMINYL CYCLOTRANSFERASE FROM CARICA PAPAYA.
Descriptor:GLUTAMINE CYCLOTRANSFERASE, CALCIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Guevara, T., Mallorqui-Fernandez, N., Garcia-Castellanos, R., Petersen, G.E., Lauritzen, C., Pedersen, J., Arnau, J., Gomis-Ruth, F.X., Sola, M.
Deposit date:2006-06-27
Release date:2006-07-04
Last modified:2019-05-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Papaya Glutamine Cyclotransferase Shows a Singular Five-Fold Beta-Propeller Architecture that Suggests a Novel Reaction Mechanism.
Biol.Chem., 387, 2006
3LQ0
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ZYMOGEN STRUCTURE OF CRAYFISH ASTACIN METALLOPEPTIDASE
Descriptor:ProAstacin, ZINC ION, GLYCEROL, ...
Authors:Guevara, T., Yiallouros, I., Kappelhoff, R., Bissdorf, S., Stocker, W., Gomis-Ruth, F.X.
Deposit date:2010-02-08
Release date:2010-02-23
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Proenzyme structure and activation of astacin metallopeptidase
J.Biol.Chem., 285, 2010
6I9A
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PORPHYROMONAS GINGIVALIS GINGIPAIN K (KGP) IN COMPLEX WITH INHIBITOR KYT-36
Descriptor:Lys-gingipain W83, UNKNOWN ATOM OR ION, SODIUM ION, ...
Authors:Gomis-Ruth, F.X., Guevara, T., Rofdriguez-Banqueri, A.
Deposit date:2018-11-22
Release date:2019-03-13
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural determinants of inhibition of Porphyromonas gingivalis gingipain K by KYT-36, a potent, selective, and bioavailable peptidase inhibitor.
Sci Rep, 9, 2019
4YT9
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CRYSTAL STRUCTURE OF PORPHYROMONAS GINGIVALIS PEPTIDYLARGININE DEIMINASE (PPAD) SUBSTRATE-UNBOUND.
Descriptor:Peptidylarginine deiminase, SODIUM ION, GLYCEROL
Authors:Goulas, T., Mizgalska, D., Garcia-Ferrer, I., Kantyka, T., Guevara, T., Szmigielski, B., Sroka, A., Millan, C., Uson, I., Veillard, F., Potempa, B., Mydel, P., Sola, M., Potempa, J., Gomis-Ruth, F.X.
Deposit date:2015-03-17
Release date:2015-07-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase.
Sci Rep, 5, 2015
4YTB
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CRYSTAL STRUCTURE OF PORPHYROMONAS GINGIVALIS PEPTIDYLARGININE DEIMINASE (PPAD) IN COMPLEX WITH DIPEPTIDE ASP-GLN.
Descriptor:Peptidylarginine deiminase, SODIUM ION, ASPARTIC ACID, ...
Authors:Goulas, T., Mizgalska, D., Garcia-Ferrer, I., Kantyka, T., Guevara, T., Szmigielski, B., Sroka, A., Millan, C., Uson, I., Veillard, F., Potempa, B., Mydel, P., Sola, M., Potempa, J., Gomis-Ruth, F.X.
Deposit date:2015-03-17
Release date:2015-07-01
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase.
Sci Rep, 5, 2015
4YTG
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CRYSTAL STRUCTURE OF PORPHYROMONAS GINGIVALIS PEPTIDYLARGININE DEIMINASE (PPAD) MUTANT C351A IN COMPLEX WITH DIPEPTIDE MET-ARG.
Descriptor:Peptidylarginine deiminase, SODIUM ION, CYSTEINE, ...
Authors:Goulas, T., Mizgalska, D., Garcia-Ferrer, I., Kantyka, T., Guevara, T., Szmigielski, B., Sroka, A., Millan, C., Uson, I., Veillard, F., Potempa, B., Mydel, P., Sola, M., Potempa, J., Gomis-Ruth, F.X.
Deposit date:2015-03-17
Release date:2015-07-01
Last modified:2018-09-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and mechanism of a bacterial host-protein citrullinating virulence factor, Porphyromonas gingivalis peptidylarginine deiminase.
Sci Rep, 5, 2015
3D4U
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BOVINE THROMBIN-ACTIVATABLE FIBRINOLYSIS INHIBITOR (TAFIA) IN COMPLEX WITH TICK-DERIVED CARBOXYPEPTIDASE INHIBITOR.
Descriptor:Carboxypeptidase B2, Carboxypeptidase inhibitor, ZINC ION, ...
Authors:Sanglas, L., Valnickova, Z., Arolas, J.L., Pallares, I., Guevara, T., Sola, M., Kristensen, T., Enghild, J.J., Aviles, F.X., Gomis-Ruth, F.X.
Deposit date:2008-05-15
Release date:2008-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of activated thrombin-activatable fibrinolysis inhibitor, a molecular link between coagulation and fibrinolysis.
Mol.Cell, 31, 2008
3H8T
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STRUCTURE OF PORPHYROMONAS GINGIVALIS HEME-BINDING PROTEIN HMUY IN COMPLEX WITH HEME
Descriptor:HmuY, PROTOPORPHYRIN IX CONTAINING FE, GLYCEROL, ...
Authors:Wojtowicz, H., Guevara, T., Tallant, C., Olczak, M., Sroka, A., Potempa, J., Sola, M., Olczak, T., Gomis-Ruth, F.X.
Deposit date:2009-04-29
Release date:2009-05-12
Last modified:2012-11-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Unique structure and stability of HmuY, a novel heme-binding protein of Porphyromonas gingivalis
Plos Pathog., 5, 2009
4ACQ
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ALPHA-2 MACROGLOBULIN
Descriptor:ALPHA-2-MACROGLOBULIN, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE
Authors:Marrero, A., Duquerroy, S., Trapani, S., Goulas, T., Guevara, T., Andersen, G.R., Navaza, J., Sottrup-Jensen, L., Gomis-Ruth, F.X.
Deposit date:2011-12-17
Release date:2012-02-22
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:The crystal structure of human alpha 2-macroglobulin reveals a unique molecular cage.
Angew. Chem. Int. Ed. Engl., 51, 2012
4GWM
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CRYSTAL STRUCTURE OF HUMAN PROMEPRIN BETA
Descriptor:Meprin A subunit beta, ZINC ION, SODIUM ION, ...
Authors:Arolas, J.L., Broder, C., Jefferson, T., Guevara, T., Sterchi, E.E., Bode, W., Stocker, W., Becker-Pauly, C., Gomis-Ruth, F.X.
Deposit date:2012-09-03
Release date:2012-09-19
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for the sheddase function of human meprin beta metalloproteinase at the plasma membrane
Proc.Natl.Acad.Sci.USA, 109, 2012
4GWN
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CRYSTAL STRUCTURE OF HUMAN MATURE MEPRIN BETA
Descriptor:Meprin A subunit beta, CADMIUM ION, SODIUM ION, ...
Authors:Arolas, J.L., Broder, C., Jefferson, T., Guevara, T., Sterchi, E.E., Bode, W., Stocker, W., Becker-Pauly, C., Gomis-Ruth, F.X.
Deposit date:2012-09-03
Release date:2012-09-19
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for the sheddase function of human meprin beta metalloproteinase at the plasma membrane
Proc.Natl.Acad.Sci.USA, 109, 2012
4IJA
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STRUCTURE OF S. AUREUS METHICILLIN RESISTANCE FACTOR MECR2
Descriptor:XylR protein, PHOSPHATE ION, GLYCEROL, ...
Authors:Arede, P., Botelho, T., Guevara, T., Uson, I., Oliveira, D.C., Gomis-Ruth, F.X.
Deposit date:2012-12-21
Release date:2013-06-12
Last modified:2013-08-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-Function Studies of the Staphylococcal Methicillin Resistance Antirepressor MecR2.
J.Biol.Chem., 288, 2013
5M11
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STRUCTURAL AND FUNCTIONAL PROBING OF PORZ, AN ESSENTIAL BACTERIAL SURFACE COMPONENT OF THE TYPE-IX SECRETION SYSTEM OF HUMAN ORAL-MICROBIOMIC PORPHYROMONAS GINGIVALIS.
Descriptor:Immunoreactive 84kD antigen PG93, CALCIUM ION, ZINC ION, ...
Authors:Lasica, A.M., Goulas, T., Mizgalska, D., Zhou, X., Ksiazek, M., Madej, M., Guo, Y., Guevara, T., Nowak, M., Potempa, B., Goel, A., Sztukowska, M., Prabhakar, A.T., Bzowska, M., Widziolek, M., Thogersen, I.B., Enghild, J.J., Simonian, M., Kulczyk, A.W., Nguyen, K.-A., Potempa, J., Gomis-Ruth, F.X.
Deposit date:2016-10-07
Release date:2016-11-09
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis.
Sci Rep, 6, 2016
5MUN
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STRUCTURAL INSIGHT INTO ZYMOGENIC LATENCY OF GINGIPAIN K FROM PORPHYROMONAS GINGIVALIS.
Descriptor:Lys-gingipain W83, AZIDE ION
Authors:Pomowski, A., Uson, I., Nowakovska, Z., Veillard, F., Sztukowska, M.N., Guevara, T., Goulas, T., Mizgalska, D., Nowak, M., Potempa, B., Huntington, J.A., Potempa, J., Gomis-Ruth, F.X.
Deposit date:2017-01-13
Release date:2017-02-22
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K from Porphyromonas gingivalis, a causative agent of gum disease from the human oral microbiome.
J. Biol. Chem., 292, 2017
6HT9
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MOUSE FETUIN-B IN COMPLEX WITH CRAYFISH ASTACIN
Descriptor:Astacin, Fetuin-B, ZINC ION, ...
Authors:Gomis-Ruth, F.X., Goulas, T., Guevara, T., Cuppari, A.
Deposit date:2018-10-03
Release date:2019-03-13
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of mammalian plasma fetuin-B and its mechanism of selective metallopeptidase inhibition.
Iucrj, 6, 2019
3RAM
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CRYSTAL STRUCTURE OF HMRA
Descriptor:HmrA protein, ZINC ION, GLYCEROL
Authors:Botelho, T., Guevara, T., Marrero, A., Gomis-Ruth, F.X.
Deposit date:2011-03-28
Release date:2011-05-25
Last modified:2011-08-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Functional Analyses Reveal That Staphylococcus aureus Antibiotic Resistance Factor HmrA Is a Zinc-dependent Endopeptidase.
J.Biol.Chem., 286, 2011
2XS3
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STRUCTURE OF KARILYSIN CATALYTIC MMP DOMAIN
Descriptor:KARILYSIN PROTEASE, PEPTIDE ALA-PHE-THR-SER, ZINC ION, ...
Authors:Cerda-Costa, N., Guevara, T., Karim, A.Y., Ksiazek, M., Nguyen, K.-A., Arolas, J.L., Potempa, J., Gomis-Ruth, F.X.
Deposit date:2010-09-24
Release date:2010-11-03
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Structure of the Catalytic Domain of Tannerella Forsythia Karilysin Reveals It is a Bacterial Xenologue of Animal Matrix Metalloproteinases.
Mol.Microbiol., 79, 2011
2XS4
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STRUCTURE OF KARILYSIN CATALYTIC MMP DOMAIN IN COMPLEX WITH MAGNESIUM
Descriptor:KARILYSIN PROTEASE, PEPTIDE ALA-PHE-THR, MAGNESIUM ION, ...
Authors:Cerda-Costa, N., Guevara, T., Karim, A.Y., Ksiazek, M., Nguyen, K.-A., Arolas, J.L., Potempa, J., Gomis-Ruth, F.X.
Deposit date:2010-09-24
Release date:2010-11-03
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Structure of the Catalytic Domain of Tannerella Forsythia Karilysin Reveals It is a Bacterial Xenologue of Animal Matrix Metalloproteinases.
Mol.Microbiol., 79, 2011
2IWB
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MECR1 UNBOUND EXTRACELLULAR ANTIBIOTIC-SENSOR DOMAIN.
Descriptor:METHICILLIN RESISTANCE MECR1 PROTEIN, TETRAPEPTIDE, NICKEL (II) ION, ...
Authors:Marrero, A., Mallorqui-Fernandez, G., Guevara, T., Garcia-Castellanos, R., Gomis-Ruth, F.X.
Deposit date:2006-06-27
Release date:2006-07-04
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Unbound and Acylated Structures of the Mecr1 Extracellular Antibiotic-Sensor Domain Provide Insights Into the Signal-Transduction System that Triggers Methicillin Resistance.
J.Mol.Biol., 361, 2006
2IWC
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BENZYLPENICILLOYL-ACYLATED MECR1 EXTRACELLULAR ANTIBIOTIC-SENSOR DOMAIN.
Descriptor:METHICILLIN RESISTANCE MECR1 PROTEIN, OPEN FORM - PENICILLIN G
Authors:Marrero, A., Mallorqui-Fernandez, G., Guevara, T., Garcia-Castellanos, R., Gomis-Ruth, F.X.
Deposit date:2006-06-27
Release date:2006-07-04
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Unbound and Acylated Structures of the Mecr1 Extracellular Antibiotic-Sensor Domain Provide Insights Into the Signal-Transduction System that Triggers Methicillin Resistance.
J.Mol.Biol., 361, 2006
2IWD
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OXACILLOYL-ACYLATED MECR1 EXTRACELLULAR ANTIBIOTIC-SENSOR DOMAIN.
Descriptor:Methicillin resistance mecR1 protein, (2R,4S)-5,5-dimethyl-2-[(1R)-1-{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}-2-oxoethyl]-1,3-thiazolidine-4-carboxylic acid
Authors:Marrero, A., Mallorqui-Fernandez, G., Guevara, T., Garcia-Castellanos, R., Gomis-Ruth, F.X.
Deposit date:2006-06-27
Release date:2006-07-03
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Unbound and Acylated Structures of the Mecr1 Extracellular Antibiotic-Sensor Domain Provide Insights Into the Signal-Transduction System that Triggers Methicillin Resistance.
J.Mol.Biol., 361, 2006
3MN8
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STRUCTURE OF DROSOPHILA MELANOGASTER CARBOXYPEPTIDASE D ISOFORM 1B SHORT
Descriptor:LP15968p, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
Authors:Tanco, S., Arolas, J.L., Guevara, T., Lorenzo, J., Aviles, F.X., Gomis-Ruth, F.X.
Deposit date:2010-04-21
Release date:2010-07-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure-Function Analysis of the Short Splicing Variant Carboxypeptidase Encoded by Drosophila melanogaster silver.
J.Mol.Biol., 401, 2010
4IEF
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COMPLEX OF PORPHYROMONAS GINGIVALIS RGPB PRO- AND MATURE DOMAINS
Descriptor:Gingipain R2 Pro-Domain, Gingipain R2 Mature Domain, CHLORIDE ION, ...
Authors:de Diego, I., Veillard, F.T., Guevara, T., Potempa, B., Sztukowska, M., Potempa, J., Gomis-Ruth, F.X.
Deposit date:2012-12-13
Release date:2013-04-10
Last modified:2017-03-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Porphyromonas gingivalis Virulence Factor Gingipain RgpB Shows a Unique Zymogenic Mechanism for Cysteine Peptidases.
J.Biol.Chem., 288, 2013
4R3V
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STRUCTURE OF KARILYSIN PROPEPTIDE AND CATALYTIC MMP DOMAIN
Descriptor:Karilysin, ZINC ION, CALCIUM ION, ...
Authors:Lopez-Pelegrin, M., Ksiazek, M., Karim, A.Y., Guevara, T., Arolas, J.L., Potempa, J., Gomis-Ruth, F.X.
Deposit date:2014-08-18
Release date:2015-01-07
Last modified:2015-03-11
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:A novel mechanism of latency in matrix metalloproteinases.
J.Biol.Chem., 290, 2015
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