Author results

3NX1
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CRYSTAL STRUCTURE OF ENTEROBACTER SP. PX6-4 FERULIC ACID DECARBOXYLASE
分子名称:Ferulic acid decarboxylase
著者Gu, W., Yang, J.K., Lou, Z.Y., Meng, Z.H., Zhang, K.-Q.
登録日2010-07-12
公開日2011-02-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural Basis of Enzymatic Activity for the Ferulic Acid Decarboxylase (FADase) from Enterobacter sp. Px6-4
Plos One, 6, 2011
3NX2
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ENTEROBACTER SP. PX6-4 FERULIC ACID DECARBOXYLASE IN COMPLEX WITH SUBSTRATE ANALOGUES
分子名称:Ferulic acid decarboxylase, 3-(4-HYDROXY-3-METHOXYPHENYL)-2-PROPENOIC ACID
著者Gu, W., Yang, J.K., Lou, Z.Y., Meng, Z.H., Zhang, K.-Q.
登録日2010-07-12
公開日2011-02-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structural Basis of Enzymatic Activity for the Ferulic Acid Decarboxylase (FADase) from Enterobacter sp. Px6-4
Plos One, 6, 2011
1NB8
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STRUCTURE OF THE CATALYTIC DOMAIN OF USP7 (HAUSP)
分子名称:Ubiquitin carboxyl-terminal hydrolase 7
著者Hu, M., Li, P., Li, M., Li, W., Yao, T., Wu, J.-W., Gu, W., Cohen, R.E., Shi, Y.
登録日2002-12-02
公開日2003-01-07
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde
Cell(Cambridge,Mass.), 111, 2002
1NBF
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CRYSTAL STRUCTURE OF A UBP-FAMILY DEUBIQUITINATING ENZYME IN ISOLATION AND IN COMPLEX WITH UBIQUITIN ALDEHYDE
分子名称:Ubiquitin carboxyl-terminal hydrolase 7, Ubiquitin aldehyde
著者Hu, M., Li, P., Li, M., Li, W., Yao, T., Wu, J.-W., Gu, W., Cohen, R.E., Shi, Y.
登録日2002-12-02
公開日2003-01-07
最終更新日2018-10-03
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde
Cell(Cambridge,Mass.), 111, 2002
1X81
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FARNESYL TRANSFERASE STRUCTURE OF JANSEN COMPOUND
分子名称:Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit, Protein farnesyltransferase beta subunit, ZINC ION, ...
著者Li, Q., Claiborne, A., Li, T., Hasvold, L., Stoll, V.S., Muchmore, S., Jakob, C.G., Gu, W., Cohen, J., Hutchins, C., Frost, D., Rosenberg, S.H., Sham, H.L.
登録日2004-08-16
公開日2004-12-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Design, synthesis, and activity of 4-quinolone and pyridone compounds as nonthiol-containing farnesyltransferase inhibitors.
Bioorg.Med.Chem.Lett., 14, 2004
6O0Q
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CRYSTAL STRUCTURE OF THE TIR DOMAIN FROM HUMAN SARM1 IN COMPLEX WITH RIBOSE
分子名称:Sterile alpha and TIR motif-containing protein 1, BETA-D-RIBOFURANOSYL, CHLORIDE ION
著者Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Deerain, N., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.
登録日2019-02-17
公開日2019-09-04
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献NAD+cleavage activity by animal and plant TIR domains in cell death pathways.
Science, 365, 2019
6O0R
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CRYSTAL STRUCTURE OF THE TIR DOMAIN FROM HUMAN SARM1 IN COMPLEX WITH GLYCEROL
分子名称:Sterile alpha and TIR motif-containing protein 1, GLYCEROL
著者Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Deerain, N., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.
登録日2019-02-17
公開日2019-09-04
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献NAD+cleavage activity by animal and plant TIR domains in cell death pathways.
Science, 365, 2019
6O0S
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CRYSTAL STRUCTURE OF THE TANDEM SAM DOMAINS FROM HUMAN SARM1
分子名称:Sterile alpha and TIR motif-containing protein 1
著者Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Deerain, N., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.
登録日2019-02-17
公開日2019-09-04
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献NAD+cleavage activity by animal and plant TIR domains in cell death pathways.
Science, 365, 2019
6O0T
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CRYSTAL STRUCTURE OF SELENOMETHIONINE LABELLED TANDEM SAM DOMAINS (L446M:L505M:L523M MUTANT) FROM HUMAN SARM1
分子名称:Sterile alpha and TIR motif-containing protein 1
著者Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Deerain, N., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.
登録日2019-02-17
公開日2019-09-04
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献NAD+cleavage activity by animal and plant TIR domains in cell death pathways.
Science, 365, 2019
6O0U
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CRYSTAL STRUCTURE OF THE TIR DOMAIN H685A MUTANT FROM HUMAN SARM1
分子名称:Sterile alpha and TIR motif-containing protein 1
著者Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.
登録日2019-02-17
公開日2019-09-04
実験手法X-RAY DIFFRACTION (3.03 Å)
主引用文献NAD+cleavage activity by animal and plant TIR domains in cell death pathways.
Science, 365, 2019
6O0V
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CRYSTAL STRUCTURE OF THE TIR DOMAIN G601P MUTANT FROM HUMAN SARM1, CRYSTAL FORM 2
分子名称:Sterile alpha and TIR motif-containing protein 1, CHLORIDE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
著者Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.
登録日2019-02-17
公開日2019-09-04
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献NAD+cleavage activity by animal and plant TIR domains in cell death pathways.
Science, 365, 2019
6O0W
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CRYSTAL STRUCTURE OF THE TIR DOMAIN FROM THE GRAPEVINE DISEASE RESISTANCE PROTEIN RUN1 IN COMPLEX WITH NADP+ AND BIS-TRIS
分子名称:TIR-NB-LRR type resistance protein RUN1, ADENOSINE-2'-5'-DIPHOSPHATE, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
著者Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.
登録日2019-02-17
公開日2019-09-04
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献NAD+cleavage activity by animal and plant TIR domains in cell death pathways.
Science, 365, 2019
6O1B
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CRYSTAL STRUCTURE OF THE TIR DOMAIN G601P MUTANT FROM HUMAN SARM1, CRYSTAL FORM 1
分子名称:Sterile alpha and TIR motif-containing protein 1, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
著者Horsefield, S., Burdett, H., Zhang, X., Manik, M.K., Shi, Y., Chen, J., Tiancong, Q., Gilley, J., Lai, J., Gu, W., Rank, M., Casey, L., Ericsson, D.J., Foley, G., Hughes, R.O., Bosanac, T., von Itzstein, M., Rathjen, J.P., Nanson, J.D., Boden, M., Dry, I.B., Williams, S.J., Staskawicz, B.J., Coleman, M.P., Ve, T., Dodds, P.N., Kobe, B.
登録日2019-02-18
公開日2019-09-04
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献NAD+cleavage activity by animal and plant TIR domains in cell death pathways.
Science, 365, 2019
2F1W
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CRYSTAL STRUCTURE OF THE TRAF-LIKE DOMAIN OF HAUSP/USP7
分子名称:Ubiquitin carboxyl-terminal hydrolase 7, CALCIUM ION
著者Hu, M., Gu, L., Jeffrey, P.D., Shi, Y.
登録日2005-11-15
公開日2006-02-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.
Plos Biol., 4, 2006
2F1X
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CRYSTAL STRUCTURE OF THE TRAF-LIKE DOMAIN OF HAUSP/USP7 BOUND TO A P53 PEPTIDE
分子名称:HAUSP/USP7
著者Hu, M., Gu, L., Jeffrey, P.D., Shi, Y.
登録日2005-11-15
公開日2006-02-07
最終更新日2017-08-16
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.
Plos Biol., 4, 2006
2F1Y
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CRYSTAL STRUCTURE OF THE TRAF-LIKE DOMAIN OF HAUSP/USP7 BOUND TO A MDM2 PEPTIDE
分子名称:HAUSP/USP7
著者Hu, M., Gu, L., Jeffrey, P.D., Shi, Y.
登録日2005-11-15
公開日2006-02-07
最終更新日2017-08-16
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.
Plos Biol., 4, 2006
2F1Z
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CRYSTAL STRUCTURE OF HAUSP
分子名称:Ubiquitin carboxyl-terminal hydrolase 7
著者Hu, M., Gu, L., Jeffrey, P.D., Shi, Y.
登録日2005-11-15
公開日2006-02-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.
Plos Biol., 4, 2006
2OSE
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CRYSTAL STRUCTURE OF THE MIMIVIRUS CYCLOPHILIN
分子名称:Probable peptidyl-prolyl cis-trans isomerase, CHLORIDE ION
著者Eisenmesser, E.Z., Thai, V., Renesto, P., Raoult, D.
登録日2007-02-05
公開日2007-12-18
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Structural, biochemical, and in vivo characterization of the first virally encoded cyclophilin from the Mimivirus.
J.Mol.Biol., 378, 2008
4NCE
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INFLUENZA POLYMERASE BASIC PROTEIN 2 (PB2) BOUND TO 7-METHYL-GTP
分子名称:Polymerase basic protein 2, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, 9,10-dioxo-9,10-dihydroanthracene-2,6-disulfonic acid
著者Jacobs, M.D.
登録日2013-10-24
公開日2014-07-30
最終更新日2014-08-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2.
J.Med.Chem., 57, 2014
4NCM
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INFLUENZA POLYMERASE BASIC PROTEIN 2 (PB2) BOUND TO A SMALL-MOLECULE INHIBITOR
分子名称:Polymerase basic protein 2, N~2~-[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-N,N-dimethyl-L-alaninamide
著者Jacobs, M.D.
登録日2013-10-24
公開日2014-07-30
最終更新日2014-08-27
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2.
J.Med.Chem., 57, 2014
4P1U
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INFLUENZA A (FLU) VIRUS POLYMERASE BASIC PROTEIN 2 (PB2) BOUND TO VX787, AN AZAINDOLE INHIBITOR
分子名称:Polymerase basic protein 2, (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid
著者Jacobs, M.D.
登録日2014-02-27
公開日2014-07-30
最終更新日2014-10-01
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2.
J.Med.Chem., 57, 2014
4YD0
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INFLUENZA POLYMERASE BASIC PROTEIN 2 (PB2) BOUND TO AN AZAINDOLE-TETRAZOLE INHIBITOR
分子名称:Polymerase basic protein 2, 2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoro-N-[(1R,2S,3S,4R)-3-(1H-tetrazol-5-yl)bicyclo[2.2.2]oct-2-yl]pyrimidin-4-amine
著者Jacobs, M.D.
登録日2015-02-20
公開日2015-04-15
最終更新日2015-05-06
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors.
Bioorg.Med.Chem.Lett., 25, 2015
5BUH
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INFLUENZA PB2 BOUND TO A HYDROXYMETHYL AZAINDOLE INHIBITOR
分子名称:Polymerase basic protein 2, N-[(1R,3S)-3-({5-fluoro-2-[5-fluoro-2-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl}amino)cyclohexyl]pyrrolidine-1-carboxamide
著者Jacobs, M.D.
登録日2015-06-03
公開日2016-06-08
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza.
ACS Med Chem Lett, 8, 2017
5F79
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INFLUENZA PB2 BOUND TO AN AZAINDOLE INHIBITOR
分子名称:Polymerase basic protein 2, N-[(1R,3S)-3-({5-fluoro-2-[5-fluoro-2-(hydroxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-4-yl}amino)cyclohexyl]pyrrolidine-1-carboxamide
著者Jacobs, M.D.
登録日2015-12-07
公開日2016-12-07
最終更新日2017-03-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Novel 2-Substituted 7-Azaindole and 7-Azaindazole Analogues as Potential Antiviral Agents for the Treatment of Influenza.
ACS Med Chem Lett, 8, 2017
5JUN
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PB2 BOUND TO AN AZAINDOLE INHIBITOR
分子名称:Polymerase basic protein 2, (3~{R})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]-3-(1-methylcyclobutyl)propanoic acid
著者Jacobs, M.D.
登録日2016-05-10
公開日2017-05-17
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Discovery of Novel, Orally Bioavailable beta-Amino Acid Azaindole Inhibitors of Influenza PB2.
ACS Med Chem Lett, 8, 2017
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