Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
4MXI
DownloadVisualize
BU of 4mxi by Molmil
ClpP Ser98dhA
Descriptor: ATP-dependent Clp protease proteolytic subunit
Authors:Gersch, M, Kolb, R, Alte, F, Groll, M, Sieber, S.A.
Deposit date:2013-09-26
Release date:2013-10-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Disruption of Oligomerization and Dehydroalanine Formation as Mechanisms for ClpP Protease Inhibition.
J.Am.Chem.Soc., 136, 2014
3V5E
DownloadVisualize
BU of 3v5e by Molmil
Crystal structure of ClpP from Staphylococcus aureus in the active, extended conformation
Descriptor: ATP-dependent Clp protease proteolytic subunit
Authors:Gersch, M, List, A, Groll, M, Sieber, S.
Deposit date:2011-12-16
Release date:2012-02-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insights into structural network responsible for oligomerization and activity of bacterial virulence regulator caseinolytic protease P (ClpP) protein.
J.Biol.Chem., 287, 2012
5OHP
DownloadVisualize
BU of 5ohp by Molmil
Crystal structure of USP30 (C77A) in complex with Lys6-linked diubiquitin
Descriptor: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 30, ZINC ION
Authors:Gersch, M, Komander, D.
Deposit date:2017-07-17
Release date:2017-09-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mechanism and regulation of the Lys6-selective deubiquitinase USP30.
Nat. Struct. Mol. Biol., 24, 2017
5OHK
DownloadVisualize
BU of 5ohk by Molmil
Crystal structure of USP30 in covalent complex with ubiquitin propargylamide (high resolution)
Descriptor: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 30,Ubiquitin carboxyl-terminal hydrolase 30,Ubiquitin carboxyl-terminal hydrolase 30, ZINC ION, ...
Authors:Gersch, M, Komander, D.
Deposit date:2017-07-17
Release date:2017-09-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Mechanism and regulation of the Lys6-selective deubiquitinase USP30.
Nat. Struct. Mol. Biol., 24, 2017
5OHN
DownloadVisualize
BU of 5ohn by Molmil
Crystal structure of USP30 in covalent complex with ubiquitin propargylamide (low resolution)
Descriptor: Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 30,Ubiquitin carboxyl-terminal hydrolase 30, ZINC ION
Authors:Gersch, M, Komander, D.
Deposit date:2017-07-17
Release date:2017-09-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Mechanism and regulation of the Lys6-selective deubiquitinase USP30.
Nat. Struct. Mol. Biol., 24, 2017
6HEJ
DownloadVisualize
BU of 6hej by Molmil
Structure of human USP28
Descriptor: SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 28
Authors:Gersch, M, Komander, D.
Deposit date:2018-08-20
Release date:2019-03-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
6HEM
DownloadVisualize
BU of 6hem by Molmil
Structure of the C-terminal domain of USP25 (748-1048)
Descriptor: GLYCEROL, SODIUM ION, Ubiquitin carboxyl-terminal hydrolase 25
Authors:Gersch, M, Komander, D.
Deposit date:2018-08-20
Release date:2019-03-27
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
6HEK
DownloadVisualize
BU of 6hek by Molmil
Structure of human USP28 bound to Ubiquitin-PA
Descriptor: CHLORIDE ION, Polyubiquitin-B, TETRAETHYLENE GLYCOL, ...
Authors:Gersch, M, Komander, D.
Deposit date:2018-08-20
Release date:2019-03-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
6HEH
DownloadVisualize
BU of 6heh by Molmil
Structure of the catalytic domain of USP28 (insertion deleted)
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Ubiquitin carboxyl-terminal hydrolase 28,Ubiquitin carboxyl-terminal hydrolase 28
Authors:Gersch, M, Komander, D.
Deposit date:2018-08-20
Release date:2019-03-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
6HEI
DownloadVisualize
BU of 6hei by Molmil
Structure of the catalytic domain of USP28 (insertion deleted) bound to Ubiquitin-PA
Descriptor: 1,2-ETHANEDIOL, Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 28,Ubiquitin carboxyl-terminal hydrolase 28
Authors:Gersch, M, Komander, D.
Deposit date:2018-08-20
Release date:2019-03-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
6HEL
DownloadVisualize
BU of 6hel by Molmil
Structure of human USP25
Descriptor: Ubiquitin carboxyl-terminal hydrolase 25
Authors:Gersch, M, Komander, D.
Deposit date:2018-08-20
Release date:2019-03-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.941 Å)
Cite:Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
3V5I
DownloadVisualize
BU of 3v5i by Molmil
The crystal structure of the mutant ClpP S98A (Staphylococcus aureus)
Descriptor: ATP-dependent Clp protease proteolytic subunit
Authors:List, A, Gersch, M, Groll, M, Sieber, S.
Deposit date:2011-12-16
Release date:2012-02-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insights into structural network responsible for oligomerization and activity of bacterial virulence regulator caseinolytic protease P (ClpP) protein.
J.Biol.Chem., 287, 2012
8C61
DownloadVisualize
BU of 8c61 by Molmil
Structure of USP54 in complex with Lys63-linked diUbiquitin-PA
Descriptor: CHLORIDE ION, Inactive ubiquitin carboxyl-terminal hydrolase 54, Polyubiquitin-B, ...
Authors:Wendrich, K, Gersch, M.
Deposit date:2023-01-11
Release date:2024-07-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of USP54 in complex with Lys63 linked diUbiquitin-PA
To be published
8PPW
DownloadVisualize
BU of 8ppw by Molmil
Structure of human PARK7 in complex with GK16S
Descriptor: (3~{S})-1-(iminomethyl)-~{N}-pent-4-ynyl-pyrrolidine-3-carboxamide, Parkinson disease protein 7
Authors:Grethe, C, Gersch, M.
Deposit date:2023-07-10
Release date:2024-01-31
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1.
Angew.Chem.Int.Ed.Engl., 63, 2024
8PQ0
DownloadVisualize
BU of 8pq0 by Molmil
Structure of human PARK7 in complex with GK16R
Descriptor: (3~{R})-3-(pent-4-ynylcarbamoyl)pyrrolidine-1-carboximidothioic acid, Parkinson disease protein 7
Authors:Grethe, C, Gersch, M.
Deposit date:2023-07-10
Release date:2024-01-31
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1.
Angew.Chem.Int.Ed.Engl., 63, 2024
8PW1
DownloadVisualize
BU of 8pw1 by Molmil
Structure of human UCHL1 in complex with CG341 inhibitor
Descriptor: (2~{S})-4-(iminomethyl)-1-methyl-~{N}-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]piperazine-2-carboxamide, Ubiquitin carboxyl-terminal hydrolase isozyme L1
Authors:Grethe, C, Gersch, M.
Deposit date:2023-07-19
Release date:2024-01-31
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1.
Angew.Chem.Int.Ed.Engl., 63, 2024
4R18
DownloadVisualize
BU of 4r18 by Molmil
Ligand-induced Lys33-Thr1 crosslinking at subunit beta5 of the yeast 20S proteasome
Descriptor: ALPHA-AMINOBUTYRIC ACID, MAGNESIUM ION, PROTEASOME SUBUNIT ALPHA TYPE-1, ...
Authors:Dubiella, C, Cui, H, Gersch, M, Brouwer, A.J, Sieber, S.A, Krueger, A, Liskamp, R, Groll, M.
Deposit date:2014-08-04
Release date:2014-10-15
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site.
Angew.Chem.Int.Ed.Engl., 53, 2014
4R17
DownloadVisualize
BU of 4r17 by Molmil
Ligand-induced aziridine-formation at subunit beta5 of the yeast 20S proteasome
Descriptor: (2S,3S)-3-methylaziridine-2-carboxylic acid, MAGNESIUM ION, Proteasome subunit alpha type-1, ...
Authors:Dubiella, C, Cui, H, Gersch, M, Brouwer, A.J, Sieber, S.A, Krueger, A, Liskamp, R, Groll, M.
Deposit date:2014-08-04
Release date:2014-10-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site.
Angew.Chem.Int.Ed.Engl., 53, 2014
4JCQ
DownloadVisualize
BU of 4jcq by Molmil
ClpP1 from Listeria monocytogenes
Descriptor: ATP-dependent Clp protease proteolytic subunit
Authors:Zeiler, E, List, A, Alte, F, Gersch, M, Wachtel, R, Groll, M, Sieber, S.
Deposit date:2013-02-22
Release date:2013-06-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad.
Proc.Natl.Acad.Sci.USA, 110, 2013
4JCR
DownloadVisualize
BU of 4jcr by Molmil
ClpP1 N165D mutant from Listeria monocytogenes
Descriptor: ATP-dependent Clp protease proteolytic subunit
Authors:Zeiler, E, List, A, Alte, F, Gersch, M, Wachtel, R, Groll, M, Sieber, S.
Deposit date:2013-02-22
Release date:2013-06-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad.
Proc.Natl.Acad.Sci.USA, 110, 2013
4JCT
DownloadVisualize
BU of 4jct by Molmil
ClpP2 from Listeria monocytogenes
Descriptor: ATP-dependent Clp protease proteolytic subunit
Authors:Zeiler, E, List, A, Alte, F, Gersch, M, Wachtel, R, Groll, M, Sieber, S.
Deposit date:2013-02-22
Release date:2013-06-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad.
Proc.Natl.Acad.Sci.USA, 110, 2013
5LRW
DownloadVisualize
BU of 5lrw by Molmil
Structure of Cezanne/OTUD7B OTU domain bound to ubiquitin
Descriptor: GLYCEROL, OTU domain-containing protein 7B, Polyubiquitin-B
Authors:Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
5LRV
DownloadVisualize
BU of 5lrv by Molmil
Structure of Cezanne/OTUD7B OTU domain bound to Lys11-linked diubiquitin
Descriptor: GLYCEROL, OTU domain-containing protein 7B, PHOSPHATE ION, ...
Authors:Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
5LRX
DownloadVisualize
BU of 5lrx by Molmil
Structure of A20 OTU domain bound to ubiquitin
Descriptor: Polyubiquitin-B, Tumor necrosis factor alpha-induced protein 3
Authors:Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
5LRU
DownloadVisualize
BU of 5lru by Molmil
Structure of Cezanne/OTUD7B OTU domain
Descriptor: OTU domain-containing protein 7B
Authors:Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D.
Deposit date:2016-08-22
Release date:2016-10-19
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016

 

12>

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon