7ZM0
 
 | | Structure of UCHL1 in complex with GK13S inhibitor | | Descriptor: | (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide, Ubiquitin carboxyl-terminal hydrolase isozyme L1 | | Authors: | Grethe, C, Gersch, M. | | Deposit date: | 2022-04-18 | | Release date: | 2022-09-14 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | Structural basis for specific inhibition of the deubiquitinase UCHL1.
Nat Commun, 13, 2022
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8PW1
 | | Structure of human UCHL1 in complex with CG341 inhibitor | | Descriptor: | (2~{S})-4-(iminomethyl)-1-methyl-~{N}-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]piperazine-2-carboxamide, Ubiquitin carboxyl-terminal hydrolase isozyme L1 | | Authors: | Grethe, C, Gersch, M. | | Deposit date: | 2023-07-19 | | Release date: | 2024-01-31 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1.
Angew.Chem.Int.Ed.Engl., 63, 2024
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8PQ0
 | | Structure of human PARK7 in complex with GK16R | | Descriptor: | (3~{R})-3-(pent-4-ynylcarbamoyl)pyrrolidine-1-carboximidothioic acid, Parkinson disease protein 7 | | Authors: | Grethe, C, Gersch, M. | | Deposit date: | 2023-07-10 | | Release date: | 2024-01-31 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1.
Angew.Chem.Int.Ed.Engl., 63, 2024
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8PPW
 | | Structure of human PARK7 in complex with GK16S | | Descriptor: | (3~{S})-1-(iminomethyl)-~{N}-pent-4-ynyl-pyrrolidine-3-carboxamide, Parkinson disease protein 7 | | Authors: | Grethe, C, Gersch, M. | | Deposit date: | 2023-07-10 | | Release date: | 2024-01-31 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1.
Angew.Chem.Int.Ed.Engl., 63, 2024
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