8PW1

Structure of human UCHL1 in complex with CG341 inhibitor

Summary for 8PW1

Entry DOI	10.2210/pdb8pw1/pdb
Descriptor	Ubiquitin carboxyl-terminal hydrolase isozyme L1, (2~{S})-4-(iminomethyl)-1-methyl-~{N}-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]piperazine-2-carboxamide (3 entities in total)
Functional Keywords	dub, deubiquitinase, uchl1, uch-l1, ubiquitin, nitrile, covalent, cyanopiperazine, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	10
Total formula weight	255751.38
Authors	Grethe, C.,Gersch, M. (deposition date: 2023-07-19, release date: 2024-01-31, Last modification date: 2024-03-20)
Primary citation	Schmidt, M.,Grethe, C.,Recknagel, S.,Kipka, G.M.,Klink, N.,Gersch, M. N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1. Angew.Chem.Int.Ed.Engl., 63:e202318849-e202318849, 2024 Cited by PubMed: 38239128 DOI: 10.1002/anie.202318849 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation