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8PW1

Structure of human UCHL1 in complex with CG341 inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0002176biological_processmale germ cell proliferation
A0002931biological_processresponse to ischemia
A0004197molecular_functioncysteine-type endopeptidase activity
A0004843molecular_functioncysteine-type deubiquitinase activity
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006508biological_processproteolysis
A0006511biological_processubiquitin-dependent protein catabolic process
A0007409biological_processaxonogenesis
A0007412biological_processaxon target recognition
A0007628biological_processadult walking behavior
A0008234molecular_functioncysteine-type peptidase activity
A0008242molecular_functionomega peptidase activity
A0016020cellular_componentmembrane
A0016241biological_processregulation of macroautophagy
A0016579biological_processprotein deubiquitination
A0019896biological_processaxonal transport of mitochondrion
A0030424cellular_componentaxon
A0031625molecular_functionubiquitin protein ligase binding
A0031694molecular_functionalpha-2A adrenergic receptor binding
A0042755biological_processeating behavior
A0043025cellular_componentneuronal cell body
A0043130molecular_functionubiquitin binding
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0043407biological_processnegative regulation of MAP kinase activity
A0044306cellular_componentneuron projection terminus
A0045821biological_processpositive regulation of glycolytic process
A0050905biological_processneuromuscular process
A0055001biological_processmuscle cell development
A0071466biological_processcellular response to xenobiotic stimulus
A1904115cellular_componentaxon cytoplasm
B0002176biological_processmale germ cell proliferation
B0002931biological_processresponse to ischemia
B0004197molecular_functioncysteine-type endopeptidase activity
B0004843molecular_functioncysteine-type deubiquitinase activity
B0005515molecular_functionprotein binding
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006508biological_processproteolysis
B0006511biological_processubiquitin-dependent protein catabolic process
B0007409biological_processaxonogenesis
B0007412biological_processaxon target recognition
B0007628biological_processadult walking behavior
B0008234molecular_functioncysteine-type peptidase activity
B0008242molecular_functionomega peptidase activity
B0016020cellular_componentmembrane
B0016241biological_processregulation of macroautophagy
B0016579biological_processprotein deubiquitination
B0019896biological_processaxonal transport of mitochondrion
B0030424cellular_componentaxon
B0031625molecular_functionubiquitin protein ligase binding
B0031694molecular_functionalpha-2A adrenergic receptor binding
B0042755biological_processeating behavior
B0043025cellular_componentneuronal cell body
B0043130molecular_functionubiquitin binding
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043407biological_processnegative regulation of MAP kinase activity
B0044306cellular_componentneuron projection terminus
B0045821biological_processpositive regulation of glycolytic process
B0050905biological_processneuromuscular process
B0055001biological_processmuscle cell development
B0071466biological_processcellular response to xenobiotic stimulus
B1904115cellular_componentaxon cytoplasm
C0002176biological_processmale germ cell proliferation
C0002931biological_processresponse to ischemia
C0004197molecular_functioncysteine-type endopeptidase activity
C0004843molecular_functioncysteine-type deubiquitinase activity
C0005515molecular_functionprotein binding
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006508biological_processproteolysis
C0006511biological_processubiquitin-dependent protein catabolic process
C0007409biological_processaxonogenesis
C0007412biological_processaxon target recognition
C0007628biological_processadult walking behavior
C0008234molecular_functioncysteine-type peptidase activity
C0008242molecular_functionomega peptidase activity
C0016020cellular_componentmembrane
C0016241biological_processregulation of macroautophagy
C0016579biological_processprotein deubiquitination
C0019896biological_processaxonal transport of mitochondrion
C0030424cellular_componentaxon
C0031625molecular_functionubiquitin protein ligase binding
C0031694molecular_functionalpha-2A adrenergic receptor binding
C0042755biological_processeating behavior
C0043025cellular_componentneuronal cell body
C0043130molecular_functionubiquitin binding
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0043407biological_processnegative regulation of MAP kinase activity
C0044306cellular_componentneuron projection terminus
C0045821biological_processpositive regulation of glycolytic process
C0050905biological_processneuromuscular process
C0055001biological_processmuscle cell development
C0071466biological_processcellular response to xenobiotic stimulus
C1904115cellular_componentaxon cytoplasm
D0002176biological_processmale germ cell proliferation
D0002931biological_processresponse to ischemia
D0004197molecular_functioncysteine-type endopeptidase activity
D0004843molecular_functioncysteine-type deubiquitinase activity
D0005515molecular_functionprotein binding
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006508biological_processproteolysis
D0006511biological_processubiquitin-dependent protein catabolic process
D0007409biological_processaxonogenesis
D0007412biological_processaxon target recognition
D0007628biological_processadult walking behavior
D0008234molecular_functioncysteine-type peptidase activity
D0008242molecular_functionomega peptidase activity
D0016020cellular_componentmembrane
D0016241biological_processregulation of macroautophagy
D0016579biological_processprotein deubiquitination
D0019896biological_processaxonal transport of mitochondrion
D0030424cellular_componentaxon
D0031625molecular_functionubiquitin protein ligase binding
D0031694molecular_functionalpha-2A adrenergic receptor binding
D0042755biological_processeating behavior
D0043025cellular_componentneuronal cell body
D0043130molecular_functionubiquitin binding
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0043407biological_processnegative regulation of MAP kinase activity
D0044306cellular_componentneuron projection terminus
D0045821biological_processpositive regulation of glycolytic process
D0050905biological_processneuromuscular process
D0055001biological_processmuscle cell development
D0071466biological_processcellular response to xenobiotic stimulus
D1904115cellular_componentaxon cytoplasm
E0002176biological_processmale germ cell proliferation
E0002931biological_processresponse to ischemia
E0004197molecular_functioncysteine-type endopeptidase activity
E0004843molecular_functioncysteine-type deubiquitinase activity
E0005515molecular_functionprotein binding
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005783cellular_componentendoplasmic reticulum
E0005789cellular_componentendoplasmic reticulum membrane
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0006508biological_processproteolysis
E0006511biological_processubiquitin-dependent protein catabolic process
E0007409biological_processaxonogenesis
E0007412biological_processaxon target recognition
E0007628biological_processadult walking behavior
E0008234molecular_functioncysteine-type peptidase activity
E0008242molecular_functionomega peptidase activity
E0016020cellular_componentmembrane
E0016241biological_processregulation of macroautophagy
E0016579biological_processprotein deubiquitination
E0019896biological_processaxonal transport of mitochondrion
E0030424cellular_componentaxon
E0031625molecular_functionubiquitin protein ligase binding
E0031694molecular_functionalpha-2A adrenergic receptor binding
E0042755biological_processeating behavior
E0043025cellular_componentneuronal cell body
E0043130molecular_functionubiquitin binding
E0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
E0043407biological_processnegative regulation of MAP kinase activity
E0044306cellular_componentneuron projection terminus
E0045821biological_processpositive regulation of glycolytic process
E0050905biological_processneuromuscular process
E0055001biological_processmuscle cell development
E0071466biological_processcellular response to xenobiotic stimulus
E1904115cellular_componentaxon cytoplasm
F0002176biological_processmale germ cell proliferation
F0002931biological_processresponse to ischemia
F0004197molecular_functioncysteine-type endopeptidase activity
F0004843molecular_functioncysteine-type deubiquitinase activity
F0005515molecular_functionprotein binding
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005783cellular_componentendoplasmic reticulum
F0005789cellular_componentendoplasmic reticulum membrane
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0006508biological_processproteolysis
F0006511biological_processubiquitin-dependent protein catabolic process
F0007409biological_processaxonogenesis
F0007412biological_processaxon target recognition
F0007628biological_processadult walking behavior
F0008234molecular_functioncysteine-type peptidase activity
F0008242molecular_functionomega peptidase activity
F0016020cellular_componentmembrane
F0016241biological_processregulation of macroautophagy
F0016579biological_processprotein deubiquitination
F0019896biological_processaxonal transport of mitochondrion
F0030424cellular_componentaxon
F0031625molecular_functionubiquitin protein ligase binding
F0031694molecular_functionalpha-2A adrenergic receptor binding
F0042755biological_processeating behavior
F0043025cellular_componentneuronal cell body
F0043130molecular_functionubiquitin binding
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0043407biological_processnegative regulation of MAP kinase activity
F0044306cellular_componentneuron projection terminus
F0045821biological_processpositive regulation of glycolytic process
F0050905biological_processneuromuscular process
F0055001biological_processmuscle cell development
F0071466biological_processcellular response to xenobiotic stimulus
F1904115cellular_componentaxon cytoplasm
G0002176biological_processmale germ cell proliferation
G0002931biological_processresponse to ischemia
G0004197molecular_functioncysteine-type endopeptidase activity
G0004843molecular_functioncysteine-type deubiquitinase activity
G0005515molecular_functionprotein binding
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0005783cellular_componentendoplasmic reticulum
G0005789cellular_componentendoplasmic reticulum membrane
G0005829cellular_componentcytosol
G0005886cellular_componentplasma membrane
G0006508biological_processproteolysis
G0006511biological_processubiquitin-dependent protein catabolic process
G0007409biological_processaxonogenesis
G0007412biological_processaxon target recognition
G0007628biological_processadult walking behavior
G0008234molecular_functioncysteine-type peptidase activity
G0008242molecular_functionomega peptidase activity
G0016020cellular_componentmembrane
G0016241biological_processregulation of macroautophagy
G0016579biological_processprotein deubiquitination
G0019896biological_processaxonal transport of mitochondrion
G0030424cellular_componentaxon
G0031625molecular_functionubiquitin protein ligase binding
G0031694molecular_functionalpha-2A adrenergic receptor binding
G0042755biological_processeating behavior
G0043025cellular_componentneuronal cell body
G0043130molecular_functionubiquitin binding
G0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
G0043407biological_processnegative regulation of MAP kinase activity
G0044306cellular_componentneuron projection terminus
G0045821biological_processpositive regulation of glycolytic process
G0050905biological_processneuromuscular process
G0055001biological_processmuscle cell development
G0071466biological_processcellular response to xenobiotic stimulus
G1904115cellular_componentaxon cytoplasm
H0002176biological_processmale germ cell proliferation
H0002931biological_processresponse to ischemia
H0004197molecular_functioncysteine-type endopeptidase activity
H0004843molecular_functioncysteine-type deubiquitinase activity
H0005515molecular_functionprotein binding
H0005654cellular_componentnucleoplasm
H0005737cellular_componentcytoplasm
H0005783cellular_componentendoplasmic reticulum
H0005789cellular_componentendoplasmic reticulum membrane
H0005829cellular_componentcytosol
H0005886cellular_componentplasma membrane
H0006508biological_processproteolysis
H0006511biological_processubiquitin-dependent protein catabolic process
H0007409biological_processaxonogenesis
H0007412biological_processaxon target recognition
H0007628biological_processadult walking behavior
H0008234molecular_functioncysteine-type peptidase activity
H0008242molecular_functionomega peptidase activity
H0016020cellular_componentmembrane
H0016241biological_processregulation of macroautophagy
H0016579biological_processprotein deubiquitination
H0019896biological_processaxonal transport of mitochondrion
H0030424cellular_componentaxon
H0031625molecular_functionubiquitin protein ligase binding
H0031694molecular_functionalpha-2A adrenergic receptor binding
H0042755biological_processeating behavior
H0043025cellular_componentneuronal cell body
H0043130molecular_functionubiquitin binding
H0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
H0043407biological_processnegative regulation of MAP kinase activity
H0044306cellular_componentneuron projection terminus
H0045821biological_processpositive regulation of glycolytic process
H0050905biological_processneuromuscular process
H0055001biological_processmuscle cell development
H0071466biological_processcellular response to xenobiotic stimulus
H1904115cellular_componentaxon cytoplasm
I0002176biological_processmale germ cell proliferation
I0002931biological_processresponse to ischemia
I0004197molecular_functioncysteine-type endopeptidase activity
I0004843molecular_functioncysteine-type deubiquitinase activity
I0005515molecular_functionprotein binding
I0005654cellular_componentnucleoplasm
I0005737cellular_componentcytoplasm
I0005783cellular_componentendoplasmic reticulum
I0005789cellular_componentendoplasmic reticulum membrane
I0005829cellular_componentcytosol
I0005886cellular_componentplasma membrane
I0006508biological_processproteolysis
I0006511biological_processubiquitin-dependent protein catabolic process
I0007409biological_processaxonogenesis
I0007412biological_processaxon target recognition
I0007628biological_processadult walking behavior
I0008234molecular_functioncysteine-type peptidase activity
I0008242molecular_functionomega peptidase activity
I0016020cellular_componentmembrane
I0016241biological_processregulation of macroautophagy
I0016579biological_processprotein deubiquitination
I0019896biological_processaxonal transport of mitochondrion
I0030424cellular_componentaxon
I0031625molecular_functionubiquitin protein ligase binding
I0031694molecular_functionalpha-2A adrenergic receptor binding
I0042755biological_processeating behavior
I0043025cellular_componentneuronal cell body
I0043130molecular_functionubiquitin binding
I0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
I0043407biological_processnegative regulation of MAP kinase activity
I0044306cellular_componentneuron projection terminus
I0045821biological_processpositive regulation of glycolytic process
I0050905biological_processneuromuscular process
I0055001biological_processmuscle cell development
I0071466biological_processcellular response to xenobiotic stimulus
I1904115cellular_componentaxon cytoplasm
J0002176biological_processmale germ cell proliferation
J0002931biological_processresponse to ischemia
J0004197molecular_functioncysteine-type endopeptidase activity
J0004843molecular_functioncysteine-type deubiquitinase activity
J0005515molecular_functionprotein binding
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005783cellular_componentendoplasmic reticulum
J0005789cellular_componentendoplasmic reticulum membrane
J0005829cellular_componentcytosol
J0005886cellular_componentplasma membrane
J0006508biological_processproteolysis
J0006511biological_processubiquitin-dependent protein catabolic process
J0007409biological_processaxonogenesis
J0007412biological_processaxon target recognition
J0007628biological_processadult walking behavior
J0008234molecular_functioncysteine-type peptidase activity
J0008242molecular_functionomega peptidase activity
J0016020cellular_componentmembrane
J0016241biological_processregulation of macroautophagy
J0016579biological_processprotein deubiquitination
J0019896biological_processaxonal transport of mitochondrion
J0030424cellular_componentaxon
J0031625molecular_functionubiquitin protein ligase binding
J0031694molecular_functionalpha-2A adrenergic receptor binding
J0042755biological_processeating behavior
J0043025cellular_componentneuronal cell body
J0043130molecular_functionubiquitin binding
J0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
J0043407biological_processnegative regulation of MAP kinase activity
J0044306cellular_componentneuron projection terminus
J0045821biological_processpositive regulation of glycolytic process
J0050905biological_processneuromuscular process
J0055001biological_processmuscle cell development
J0071466biological_processcellular response to xenobiotic stimulus
J1904115cellular_componentaxon cytoplasm
Functional Information from PROSITE/UniProt
site_idPS00140
Number of Residues17
DetailsUCH_1 Ubiquitin carboxyl-terminal hydrolase family 1 cysteine active-site. QtigNSCGtigLIHAVA
ChainResidueDetails
AGLN84-ALA100

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsACT_SITE: Nucleophile => ECO:0000269|PubMed:20439756
ChainResidueDetails
ACYS90
JCYS90
BCYS90
CCYS90
DCYS90
ECYS90
FCYS90
GCYS90
HCYS90
ICYS90

site_idSWS_FT_FI2
Number of Residues10
DetailsACT_SITE: Proton donor => ECO:0000269|PubMed:20439756
ChainResidueDetails
AHIS161
JHIS161
BHIS161
CHIS161
DHIS161
EHIS161
FHIS161
GHIS161
HHIS161
IHIS161

site_idSWS_FT_FI3
Number of Residues60
DetailsSITE: Susceptible to oxidation => ECO:0000269|PubMed:14722078
ChainResidueDetails
AMET1
BMET124
BMET179
BCYS220
CMET1
CMET6
CMET12
CMET124
CMET179
CCYS220
DMET1
AMET6
DMET6
DMET12
DMET124
DMET179
DCYS220
EMET1
EMET6
EMET12
EMET124
EMET179
AMET12
ECYS220
FMET1
FMET6
FMET12
FMET124
FMET179
FCYS220
GMET1
GMET6
GMET12
AMET124
GMET124
GMET179
GCYS220
HMET1
HMET6
HMET12
HMET124
HMET179
HCYS220
IMET1
AMET179
IMET6
IMET12
IMET124
IMET179
ICYS220
JMET1
JMET6
JMET12
JMET124
JMET179
ACYS220
JCYS220
BMET1
BMET6
BMET12

site_idSWS_FT_FI4
Number of Residues10
DetailsSITE: Important for enzyme activity => ECO:0000269|PubMed:8639624
ChainResidueDetails
AASP176
JASP176
BASP176
CASP176
DASP176
EASP176
FASP176
GASP176
HASP176
IASP176

site_idSWS_FT_FI5
Number of Residues10
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q00981
ChainResidueDetails
ASER125
JSER125
BSER125
CSER125
DSER125
ESER125
FSER125
GSER125
HSER125
ISER125

site_idSWS_FT_FI6
Number of Residues10
DetailsLIPID: S-farnesyl cysteine => ECO:0000269|PubMed:19261853
ChainResidueDetails
ACYS220
JCYS220
BCYS220
CCYS220
DCYS220
ECYS220
FCYS220
GCYS220
HCYS220
ICYS220

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PDB entries from 2024-05-08

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