7ZM0

Structure of UCHL1 in complex with GK13S inhibitor

Summary for 7ZM0

• Entry DOI: 10.2210/pdb7zm0/pdb
• Descriptor: Ubiquitin carboxyl-terminal hydrolase isozyme L1, (3S)-1-(iminomethyl)-N-[1-[4-(pent-4-ynylcarbamoyl)phenyl]imidazol-4-yl]pyrrolidine-3-carboxamide (3 entities in total)
• Functional Keywords: dub, uchl1, uch-l1, uchl-1, deubiquitinase, ubiquitin, cyanopyrrolidine, inhibitor, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 10
• Total formula weight: 255460.97

Authors

Grethe, C.,Gersch, M. (deposition date: 2022-04-18, release date: 2022-09-14, Last modification date: 2024-01-31)

• Primary citation: Grethe, C.,Schmidt, M.,Kipka, G.M.,O'Dea, R.,Gallant, K.,Janning, P.,Gersch, M.; Structural basis for specific inhibition of the deubiquitinase UCHL1.; Nat Commun, 13:5950-5950, 2022; PubMed: 36216817; DOI: 10.1038/s41467-022-33559-4

Experimental method

X-RAY DIFFRACTION (2.24 Å)