7ZM0

Structure of UCHL1 in complex with GK13S inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002176	biological_process	male germ cell proliferation
A	0002931	biological_process	response to ischemia
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006508	biological_process	proteolysis
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0007409	biological_process	axonogenesis
A	0007412	biological_process	axon target recognition
A	0007628	biological_process	adult walking behavior
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity
A	0008242	molecular_function	omega peptidase activity
A	0016020	cellular_component	membrane
A	0016241	biological_process	regulation of macroautophagy
A	0016579	biological_process	protein deubiquitination
A	0016787	molecular_function	hydrolase activity
A	0019896	biological_process	axonal transport of mitochondrion
A	0030163	biological_process	protein catabolic process
A	0030424	cellular_component	axon
A	0030547	molecular_function	signaling receptor inhibitor activity
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0031694	molecular_function	alpha-2A adrenergic receptor binding
A	0042755	biological_process	eating behavior
A	0043022	molecular_function	ribosome binding
A	0043025	cellular_component	neuronal cell body
A	0043130	molecular_function	ubiquitin binding
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0043409	biological_process	negative regulation of MAPK cascade
A	0044306	cellular_component	neuron projection terminus
A	0045821	biological_process	positive regulation of glycolytic process
A	0050905	biological_process	neuromuscular process
A	0055001	biological_process	muscle cell development
A	0071466	biological_process	cellular response to xenobiotic stimulus
A	1904115	cellular_component	axon cytoplasm
B	0002176	biological_process	male germ cell proliferation
B	0002931	biological_process	response to ischemia
B	0004197	molecular_function	cysteine-type endopeptidase activity
B	0004843	molecular_function	cysteine-type deubiquitinase activity
B	0005515	molecular_function	protein binding
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006508	biological_process	proteolysis
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0007409	biological_process	axonogenesis
B	0007412	biological_process	axon target recognition
B	0007628	biological_process	adult walking behavior
B	0008233	molecular_function	peptidase activity
B	0008234	molecular_function	cysteine-type peptidase activity
B	0008242	molecular_function	omega peptidase activity
B	0016020	cellular_component	membrane
B	0016241	biological_process	regulation of macroautophagy
B	0016579	biological_process	protein deubiquitination
B	0016787	molecular_function	hydrolase activity
B	0019896	biological_process	axonal transport of mitochondrion
B	0030163	biological_process	protein catabolic process
B	0030424	cellular_component	axon
B	0030547	molecular_function	signaling receptor inhibitor activity
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0031694	molecular_function	alpha-2A adrenergic receptor binding
B	0042755	biological_process	eating behavior
B	0043022	molecular_function	ribosome binding
B	0043025	cellular_component	neuronal cell body
B	0043130	molecular_function	ubiquitin binding
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0043409	biological_process	negative regulation of MAPK cascade
B	0044306	cellular_component	neuron projection terminus
B	0045821	biological_process	positive regulation of glycolytic process
B	0050905	biological_process	neuromuscular process
B	0055001	biological_process	muscle cell development
B	0071466	biological_process	cellular response to xenobiotic stimulus
B	1904115	cellular_component	axon cytoplasm
C	0002176	biological_process	male germ cell proliferation
C	0002931	biological_process	response to ischemia
C	0004197	molecular_function	cysteine-type endopeptidase activity
C	0004843	molecular_function	cysteine-type deubiquitinase activity
C	0005515	molecular_function	protein binding
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006508	biological_process	proteolysis
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0007409	biological_process	axonogenesis
C	0007412	biological_process	axon target recognition
C	0007628	biological_process	adult walking behavior
C	0008233	molecular_function	peptidase activity
C	0008234	molecular_function	cysteine-type peptidase activity
C	0008242	molecular_function	omega peptidase activity
C	0016020	cellular_component	membrane
C	0016241	biological_process	regulation of macroautophagy
C	0016579	biological_process	protein deubiquitination
C	0016787	molecular_function	hydrolase activity
C	0019896	biological_process	axonal transport of mitochondrion
C	0030163	biological_process	protein catabolic process
C	0030424	cellular_component	axon
C	0030547	molecular_function	signaling receptor inhibitor activity
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0031694	molecular_function	alpha-2A adrenergic receptor binding
C	0042755	biological_process	eating behavior
C	0043022	molecular_function	ribosome binding
C	0043025	cellular_component	neuronal cell body
C	0043130	molecular_function	ubiquitin binding
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0043409	biological_process	negative regulation of MAPK cascade
C	0044306	cellular_component	neuron projection terminus
C	0045821	biological_process	positive regulation of glycolytic process
C	0050905	biological_process	neuromuscular process
C	0055001	biological_process	muscle cell development
C	0071466	biological_process	cellular response to xenobiotic stimulus
C	1904115	cellular_component	axon cytoplasm
D	0002176	biological_process	male germ cell proliferation
D	0002931	biological_process	response to ischemia
D	0004197	molecular_function	cysteine-type endopeptidase activity
D	0004843	molecular_function	cysteine-type deubiquitinase activity
D	0005515	molecular_function	protein binding
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006508	biological_process	proteolysis
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0007409	biological_process	axonogenesis
D	0007412	biological_process	axon target recognition
D	0007628	biological_process	adult walking behavior
D	0008233	molecular_function	peptidase activity
D	0008234	molecular_function	cysteine-type peptidase activity
D	0008242	molecular_function	omega peptidase activity
D	0016020	cellular_component	membrane
D	0016241	biological_process	regulation of macroautophagy
D	0016579	biological_process	protein deubiquitination
D	0016787	molecular_function	hydrolase activity
D	0019896	biological_process	axonal transport of mitochondrion
D	0030163	biological_process	protein catabolic process
D	0030424	cellular_component	axon
D	0030547	molecular_function	signaling receptor inhibitor activity
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0031694	molecular_function	alpha-2A adrenergic receptor binding
D	0042755	biological_process	eating behavior
D	0043022	molecular_function	ribosome binding
D	0043025	cellular_component	neuronal cell body
D	0043130	molecular_function	ubiquitin binding
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0043409	biological_process	negative regulation of MAPK cascade
D	0044306	cellular_component	neuron projection terminus
D	0045821	biological_process	positive regulation of glycolytic process
D	0050905	biological_process	neuromuscular process
D	0055001	biological_process	muscle cell development
D	0071466	biological_process	cellular response to xenobiotic stimulus
D	1904115	cellular_component	axon cytoplasm
E	0002176	biological_process	male germ cell proliferation
E	0002931	biological_process	response to ischemia
E	0004197	molecular_function	cysteine-type endopeptidase activity
E	0004843	molecular_function	cysteine-type deubiquitinase activity
E	0005515	molecular_function	protein binding
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006508	biological_process	proteolysis
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0007409	biological_process	axonogenesis
E	0007412	biological_process	axon target recognition
E	0007628	biological_process	adult walking behavior
E	0008233	molecular_function	peptidase activity
E	0008234	molecular_function	cysteine-type peptidase activity
E	0008242	molecular_function	omega peptidase activity
E	0016020	cellular_component	membrane
E	0016241	biological_process	regulation of macroautophagy
E	0016579	biological_process	protein deubiquitination
E	0016787	molecular_function	hydrolase activity
E	0019896	biological_process	axonal transport of mitochondrion
E	0030163	biological_process	protein catabolic process
E	0030424	cellular_component	axon
E	0030547	molecular_function	signaling receptor inhibitor activity
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0031694	molecular_function	alpha-2A adrenergic receptor binding
E	0042755	biological_process	eating behavior
E	0043022	molecular_function	ribosome binding
E	0043025	cellular_component	neuronal cell body
E	0043130	molecular_function	ubiquitin binding
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0043409	biological_process	negative regulation of MAPK cascade
E	0044306	cellular_component	neuron projection terminus
E	0045821	biological_process	positive regulation of glycolytic process
E	0050905	biological_process	neuromuscular process
E	0055001	biological_process	muscle cell development
E	0071466	biological_process	cellular response to xenobiotic stimulus
E	1904115	cellular_component	axon cytoplasm
F	0002176	biological_process	male germ cell proliferation
F	0002931	biological_process	response to ischemia
F	0004197	molecular_function	cysteine-type endopeptidase activity
F	0004843	molecular_function	cysteine-type deubiquitinase activity
F	0005515	molecular_function	protein binding
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0006508	biological_process	proteolysis
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0007409	biological_process	axonogenesis
F	0007412	biological_process	axon target recognition
F	0007628	biological_process	adult walking behavior
F	0008233	molecular_function	peptidase activity
F	0008234	molecular_function	cysteine-type peptidase activity
F	0008242	molecular_function	omega peptidase activity
F	0016020	cellular_component	membrane
F	0016241	biological_process	regulation of macroautophagy
F	0016579	biological_process	protein deubiquitination
F	0016787	molecular_function	hydrolase activity
F	0019896	biological_process	axonal transport of mitochondrion
F	0030163	biological_process	protein catabolic process
F	0030424	cellular_component	axon
F	0030547	molecular_function	signaling receptor inhibitor activity
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0031694	molecular_function	alpha-2A adrenergic receptor binding
F	0042755	biological_process	eating behavior
F	0043022	molecular_function	ribosome binding
F	0043025	cellular_component	neuronal cell body
F	0043130	molecular_function	ubiquitin binding
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0043409	biological_process	negative regulation of MAPK cascade
F	0044306	cellular_component	neuron projection terminus
F	0045821	biological_process	positive regulation of glycolytic process
F	0050905	biological_process	neuromuscular process
F	0055001	biological_process	muscle cell development
F	0071466	biological_process	cellular response to xenobiotic stimulus
F	1904115	cellular_component	axon cytoplasm
G	0002176	biological_process	male germ cell proliferation
G	0002931	biological_process	response to ischemia
G	0004197	molecular_function	cysteine-type endopeptidase activity
G	0004843	molecular_function	cysteine-type deubiquitinase activity
G	0005515	molecular_function	protein binding
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005783	cellular_component	endoplasmic reticulum
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006508	biological_process	proteolysis
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0007409	biological_process	axonogenesis
G	0007412	biological_process	axon target recognition
G	0007628	biological_process	adult walking behavior
G	0008233	molecular_function	peptidase activity
G	0008234	molecular_function	cysteine-type peptidase activity
G	0008242	molecular_function	omega peptidase activity
G	0016020	cellular_component	membrane
G	0016241	biological_process	regulation of macroautophagy
G	0016579	biological_process	protein deubiquitination
G	0016787	molecular_function	hydrolase activity
G	0019896	biological_process	axonal transport of mitochondrion
G	0030163	biological_process	protein catabolic process
G	0030424	cellular_component	axon
G	0030547	molecular_function	signaling receptor inhibitor activity
G	0031625	molecular_function	ubiquitin protein ligase binding
G	0031694	molecular_function	alpha-2A adrenergic receptor binding
G	0042755	biological_process	eating behavior
G	0043022	molecular_function	ribosome binding
G	0043025	cellular_component	neuronal cell body
G	0043130	molecular_function	ubiquitin binding
G	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
G	0043409	biological_process	negative regulation of MAPK cascade
G	0044306	cellular_component	neuron projection terminus
G	0045821	biological_process	positive regulation of glycolytic process
G	0050905	biological_process	neuromuscular process
G	0055001	biological_process	muscle cell development
G	0071466	biological_process	cellular response to xenobiotic stimulus
G	1904115	cellular_component	axon cytoplasm
H	0002176	biological_process	male germ cell proliferation
H	0002931	biological_process	response to ischemia
H	0004197	molecular_function	cysteine-type endopeptidase activity
H	0004843	molecular_function	cysteine-type deubiquitinase activity
H	0005515	molecular_function	protein binding
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005783	cellular_component	endoplasmic reticulum
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006508	biological_process	proteolysis
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0007409	biological_process	axonogenesis
H	0007412	biological_process	axon target recognition
H	0007628	biological_process	adult walking behavior
H	0008233	molecular_function	peptidase activity
H	0008234	molecular_function	cysteine-type peptidase activity
H	0008242	molecular_function	omega peptidase activity
H	0016020	cellular_component	membrane
H	0016241	biological_process	regulation of macroautophagy
H	0016579	biological_process	protein deubiquitination
H	0016787	molecular_function	hydrolase activity
H	0019896	biological_process	axonal transport of mitochondrion
H	0030163	biological_process	protein catabolic process
H	0030424	cellular_component	axon
H	0030547	molecular_function	signaling receptor inhibitor activity
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0031694	molecular_function	alpha-2A adrenergic receptor binding
H	0042755	biological_process	eating behavior
H	0043022	molecular_function	ribosome binding
H	0043025	cellular_component	neuronal cell body
H	0043130	molecular_function	ubiquitin binding
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0043409	biological_process	negative regulation of MAPK cascade
H	0044306	cellular_component	neuron projection terminus
H	0045821	biological_process	positive regulation of glycolytic process
H	0050905	biological_process	neuromuscular process
H	0055001	biological_process	muscle cell development
H	0071466	biological_process	cellular response to xenobiotic stimulus
H	1904115	cellular_component	axon cytoplasm
I	0002176	biological_process	male germ cell proliferation
I	0002931	biological_process	response to ischemia
I	0004197	molecular_function	cysteine-type endopeptidase activity
I	0004843	molecular_function	cysteine-type deubiquitinase activity
I	0005515	molecular_function	protein binding
I	0005654	cellular_component	nucleoplasm
I	0005737	cellular_component	cytoplasm
I	0005783	cellular_component	endoplasmic reticulum
I	0005789	cellular_component	endoplasmic reticulum membrane
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0006508	biological_process	proteolysis
I	0006511	biological_process	ubiquitin-dependent protein catabolic process
I	0007409	biological_process	axonogenesis
I	0007412	biological_process	axon target recognition
I	0007628	biological_process	adult walking behavior
I	0008233	molecular_function	peptidase activity
I	0008234	molecular_function	cysteine-type peptidase activity
I	0008242	molecular_function	omega peptidase activity
I	0016020	cellular_component	membrane
I	0016241	biological_process	regulation of macroautophagy
I	0016579	biological_process	protein deubiquitination
I	0016787	molecular_function	hydrolase activity
I	0019896	biological_process	axonal transport of mitochondrion
I	0030163	biological_process	protein catabolic process
I	0030424	cellular_component	axon
I	0030547	molecular_function	signaling receptor inhibitor activity
I	0031625	molecular_function	ubiquitin protein ligase binding
I	0031694	molecular_function	alpha-2A adrenergic receptor binding
I	0042755	biological_process	eating behavior
I	0043022	molecular_function	ribosome binding
I	0043025	cellular_component	neuronal cell body
I	0043130	molecular_function	ubiquitin binding
I	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
I	0043409	biological_process	negative regulation of MAPK cascade
I	0044306	cellular_component	neuron projection terminus
I	0045821	biological_process	positive regulation of glycolytic process
I	0050905	biological_process	neuromuscular process
I	0055001	biological_process	muscle cell development
I	0071466	biological_process	cellular response to xenobiotic stimulus
I	1904115	cellular_component	axon cytoplasm
J	0002176	biological_process	male germ cell proliferation
J	0002931	biological_process	response to ischemia
J	0004197	molecular_function	cysteine-type endopeptidase activity
J	0004843	molecular_function	cysteine-type deubiquitinase activity
J	0005515	molecular_function	protein binding
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005783	cellular_component	endoplasmic reticulum
J	0005789	cellular_component	endoplasmic reticulum membrane
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0006508	biological_process	proteolysis
J	0006511	biological_process	ubiquitin-dependent protein catabolic process
J	0007409	biological_process	axonogenesis
J	0007412	biological_process	axon target recognition
J	0007628	biological_process	adult walking behavior
J	0008233	molecular_function	peptidase activity
J	0008234	molecular_function	cysteine-type peptidase activity
J	0008242	molecular_function	omega peptidase activity
J	0016020	cellular_component	membrane
J	0016241	biological_process	regulation of macroautophagy
J	0016579	biological_process	protein deubiquitination
J	0016787	molecular_function	hydrolase activity
J	0019896	biological_process	axonal transport of mitochondrion
J	0030163	biological_process	protein catabolic process
J	0030424	cellular_component	axon
J	0030547	molecular_function	signaling receptor inhibitor activity
J	0031625	molecular_function	ubiquitin protein ligase binding
J	0031694	molecular_function	alpha-2A adrenergic receptor binding
J	0042755	biological_process	eating behavior
J	0043022	molecular_function	ribosome binding
J	0043025	cellular_component	neuronal cell body
J	0043130	molecular_function	ubiquitin binding
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0043409	biological_process	negative regulation of MAPK cascade
J	0044306	cellular_component	neuron projection terminus
J	0045821	biological_process	positive regulation of glycolytic process
J	0050905	biological_process	neuromuscular process
J	0055001	biological_process	muscle cell development
J	0071466	biological_process	cellular response to xenobiotic stimulus
J	1904115	cellular_component	axon cytoplasm

Functional Information from PROSITE/UniProt

site_id	PS00140
Number of Residues	17
Details	UCH_1 Ubiquitin carboxyl-terminal hydrolase family 1 cysteine active-site. QtigNSCGtigLIHAVA

Chain	Residue	Details
A	GLN84-ALA100

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	75
Details	Region: {"description":"Interaction with ubiquitin","evidences":[{"source":"PubMed","id":"20439756","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20439756","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20439756","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	59
Details	Site: {"description":"Susceptible to oxidation","evidences":[{"source":"PubMed","id":"14722078","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	10
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8639624","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	10
Details	Site: {"description":"Important for enzyme activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01393","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	10
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"37316325","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q00981","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	10
Details	Lipidation: {"description":"S-farnesyl cysteine","evidences":[{"source":"PubMed","id":"19261853","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Propeptide: {"description":"Removed in mature form","featureId":"PRO_0000414311","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---