8PQ0

Structure of human PARK7 in complex with GK16R

Summary for 8PQ0

Entry DOI	10.2210/pdb8pq0/pdb
Related	8PPW
Descriptor	Parkinson disease protein 7, (3~{R})-3-(pent-4-ynylcarbamoyl)pyrrolidine-1-carboximidothioic acid (3 entities in total)
Functional Keywords	parkinson disease protein 7, cyanopyrrolidine, dj-1, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	20310.55
Authors	Grethe, C.,Gersch, M. (deposition date: 2023-07-10, release date: 2024-01-31, Last modification date: 2024-03-20)
Primary citation	Schmidt, M.,Grethe, C.,Recknagel, S.,Kipka, G.M.,Klink, N.,Gersch, M. N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1. Angew.Chem.Int.Ed.Engl., 63:e202318849-e202318849, 2024 Cited by PubMed: 38239128 DOI: 10.1002/anie.202318849 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.48 Å)

Structure validation