6J53 | |
6J58 | |
6J5S | |
6J5Z | |
6J64 | |
6J65 | |
6ILD | | CRYSTAL STRUCTURE OF HUMAN LYSRS: P38/AIMP2 COMPLEX II | | Descriptor: | Lysine--tRNA ligase, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, LYSINE, ... | | Authors: | Hei, Z., Liu, Z., Wang, J., Fang, P. | | Deposit date: | 2018-10-17 | | Release date: | 2019-02-27 | | Last modified: | 2019-04-10 | | Method: | X-RAY DIFFRACTION (1.882 Å) | | Cite: | Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex.
J. Biol. Chem., 294, 2019
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6ILH | | CRYSTAL STRUCTURE OF HUMAN LYSYL-TRNA SYNTHETASE L350H MUTANT | | Descriptor: | Lysine-tRNA ligase, 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE | | Authors: | Hei, Z., Liu, Z., Wang, J., Fang, P. | | Deposit date: | 2018-10-18 | | Release date: | 2019-02-27 | | Last modified: | 2019-04-10 | | Method: | X-RAY DIFFRACTION (2.501 Å) | | Cite: | Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex.
J. Biol. Chem., 294, 2019
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5YZX | | CRYSTAL STRUCTURE OF E.COLI LYSU T146D MUTANT | | Descriptor: | Lysine--tRNA ligase, heat inducible, BIS(ADENOSINE)-5'-TETRAPHOSPHATE, ... | | Authors: | Fang, P., Guo, M. | | Deposit date: | 2017-12-16 | | Release date: | 2018-12-19 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | A proposed role for MSC to reserve the canonical function in high eukaryotes prior to stimuli
To Be Published
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5ED3 | | CRYSTAL STRUCTURE OF HUMAN HINT1 COMPLEXING WITH AP5A | | Descriptor: | Histidine triad nucleotide-binding protein 1, ADENOSINE MONOPHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | | Authors: | Wang, J., Fang, P., Guo, M. | | Deposit date: | 2015-10-20 | | Release date: | 2017-01-25 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (1.309 Å) | | Cite: | Convergent Regulation of Transcriptional Repression by a Second Messenger and Post-translation Modifications
To Be Published
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5ED6 | | CRYSTAL STRUCTURE OF HUMAN HINT1 H114A MUTANT COMPLEXING WITH ATP | | Descriptor: | Histidine triad nucleotide-binding protein 1, ADENOSINE MONOPHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | | Authors: | Wang, J., Fang, P., Guo, M. | | Deposit date: | 2015-10-20 | | Release date: | 2017-01-25 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | Convergent Regulation of Transcriptional Repression by a Second Messenger and Post-translation Modifications
To Be Published
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4TTV | | CRYSTAL STRUCTURE OF HUMAN THRRS COMPLEXING WITH A BIOENGINEERED MACROLIDE BC194 | | Descriptor: | Threonine--tRNA ligase, cytoplasmic, (1R,2R)-2-[(2S,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadec-6-en-2-yl]cyclobutanecarboxylic acid, ... | | Authors: | Fang, P., Guo, M. | | Deposit date: | 2014-06-23 | | Release date: | 2015-09-30 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor.
Sci Rep, 5, 2015
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5BTM | |
4YCV | |
4YCU | | CRYSTAL STRUCTURE OF CLADOSPORIN IN COMPLEX WITH HUMAN LYSYL-TRNA SYNTHETASE | | Descriptor: | Lysine--tRNA ligase, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, cladosporin, ... | | Authors: | Fang, P., Wang, J., Guo, M. | | Deposit date: | 2015-02-20 | | Release date: | 2015-06-10 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor.
Chem. Biol., 22, 2015
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4YCW | | CRYSTAL STRUCTURE OF CLADOSPORIN IN COMPLEX WITH PLASMODIUM LIKE HUMAN LYSYL-TRNA SYNTHETASE MUTANT | | Descriptor: | Lysine--tRNA ligase, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, LYSINE, ... | | Authors: | Fang, P., Wang, J., Guo, M. | | Deposit date: | 2015-02-20 | | Release date: | 2015-06-10 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural Basis for Specific Inhibition of tRNA Synthetase by ATP Competitive Inhibitor
Chem.Biol., 22, 2015
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4P3N | | STRUCTURAL BASIS FOR FULL-SPECTRUM INHIBITION OF THREONYL-TRNA SYNTHETASE BY BORRELIDIN 1 | | Descriptor: | Threonine--tRNA ligase, cytoplasmic, (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid, ... | | Authors: | Fang, P., Yu, X., Chen, K., Chen, X., Guo, M. | | Deposit date: | 2014-03-09 | | Release date: | 2015-03-11 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase.
Nat Commun, 6, 2015
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4P3O | | STRUCTURAL BASIS FOR FULL-SPECTRUM INHIBITION OF THREONYL-TRNA SYNTHETASE BY BORRELIDIN 2 | | Descriptor: | Threonine--tRNA ligase, ZINC ION, (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid, ... | | Authors: | Fang, P., Yu, X., Chen, K., Chen, X., Guo, M. | | Deposit date: | 2014-03-09 | | Release date: | 2015-03-11 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (2.505 Å) | | Cite: | Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase.
Nat Commun, 6, 2015
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4P3P | | STRUCTURAL BASIS FOR FULL-SPECTRUM INHIBITION OF THREONYL-TRNA SYNTHETASE BY BORRELIDIN 3 | | Descriptor: | Threonine--tRNA ligase, ZINC ION, (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid, ... | | Authors: | Fang, P., Yu, X., Chen, K., Chen, X., Guo, M. | | Deposit date: | 2014-03-09 | | Release date: | 2015-03-11 | | Last modified: | 2019-12-25 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase.
Nat Commun, 6, 2015
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4N20 | | CRYSTAL STRUCTURE OF PROTEIN ARGININE DEIMINASE 2 (0 MM CA2+) | | Descriptor: | Protein-arginine deiminase type-2, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ... | | Authors: | Slade, D.J., Zhang, X., Fang, P., Dreyton, C.J., Zhang, Y., Gross, M.L., Guo, M., Coonrod, S.A., Thompson, P.R. | | Deposit date: | 2013-10-04 | | Release date: | 2015-02-04 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (1.657 Å) | | Cite: | Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.
Acs Chem.Biol., 10, 2015
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4N22 | | CRYSTAL STRUCTURE OF PROTEIN ARGININE DEIMINASE 2 (50 UM CA2+) | | Descriptor: | Protein-arginine deiminase type-2, ACETATE ION, GLYCEROL, ... | | Authors: | Slade, D.J., Zhang, X., Fang, P., Dreyton, C.J., Zhang, Y., Gross, M.L., Guo, M., Coonrod, S.A., Thompson, P.R. | | Deposit date: | 2013-10-04 | | Release date: | 2015-02-04 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (1.889 Å) | | Cite: | Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.
Acs Chem.Biol., 10, 2015
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4N24 | | CRYSTAL STRUCTURE OF PROTEIN ARGININE DEIMINASE 2 (100 UM CA2+) | | Descriptor: | Protein-arginine deiminase type-2, (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ... | | Authors: | Slade, D.J., Zhang, X., Fang, P., Dreyton, C.J., Zhang, Y., Gross, M.L., Guo, M., Coonrod, S.A., Thompson, P.R. | | Deposit date: | 2013-10-04 | | Release date: | 2015-02-04 | | Last modified: | 2015-05-06 | | Method: | X-RAY DIFFRACTION (1.968 Å) | | Cite: | Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.
Acs Chem.Biol., 10, 2015
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4N25 | | CRYSTAL STRUCTURE OF PROTEIN ARGININE DEIMINASE 2 (250 UM CA2+) | | Descriptor: | Protein-arginine deiminase type-2, (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ... | | Authors: | Slade, D.J., Zhang, X., Fang, P., Dreyton, C.J., Zhang, Y., Gross, M.L., Guo, M., Coonrod, S.A., Thompson, P.R. | | Deposit date: | 2013-10-04 | | Release date: | 2015-02-04 | | Last modified: | 2015-05-06 | | Method: | X-RAY DIFFRACTION (1.931 Å) | | Cite: | Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.
Acs Chem.Biol., 10, 2015
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4N26 | | CRYSTAL STRUCTURE OF PROTEIN ARGININE DEIMINASE 2 (500 UM CA2+) | | Descriptor: | Protein-arginine deiminase type-2, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ... | | Authors: | Slade, D.J., Zhang, X., Fang, P., Dreyton, C.J., Zhang, Y., Gross, M.L., Guo, M., Coonrod, S.A., Thompson, P.R. | | Deposit date: | 2013-10-04 | | Release date: | 2015-02-04 | | Last modified: | 2015-05-06 | | Method: | X-RAY DIFFRACTION (1.943 Å) | | Cite: | Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.
Acs Chem.Biol., 10, 2015
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4N28 | | CRYSTAL STRUCTURE OF PROTEIN ARGININE DEIMINASE 2 (1 MM CA2+) | | Descriptor: | Protein-arginine deiminase type-2, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ... | | Authors: | Slade, D.J., Zhang, X., Fang, P., Dreyton, C.J., Zhang, Y., Gross, M.L., Guo, M., Coonrod, S.A., Thompson, P.R. | | Deposit date: | 2013-10-04 | | Release date: | 2015-02-04 | | Last modified: | 2015-05-06 | | Method: | X-RAY DIFFRACTION (1.879 Å) | | Cite: | Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.
Acs Chem.Biol., 10, 2015
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