Author results

6J53
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CRYSTAL STRUCTURE OF HUMAN HINT1 COMPLEXING WITH ATP
Descriptor:Histidine triad nucleotide-binding protein 1, ADENOSINE MONOPHOSPHATE
Authors:Wang, J., Fang, P., Guo, M.
Deposit date:2019-01-10
Release date:2019-09-25
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Second Messenger Ap4A Propagates Allergic Response by Polymerizing Target Protein HINT1
To Be Published
6J58
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CRYSTAL STRUCTURE OF HUMAN HINT1 COMPLEXING WITH AP4A
Descriptor:Histidine triad nucleotide-binding protein 1, ADENOSINE MONOPHOSPHATE
Authors:Wang, J., Fang, P., Guo, M.
Deposit date:2019-01-10
Release date:2019-09-25
Method:X-RAY DIFFRACTION (1.521 Å)
Cite:Second Messenger Ap4A Propagates Allergic Response by Polymerizing Target Protein HINT1
To Be Published
6J5S
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CRYSTAL STRUCTURE OF HUMAN HINT1 MUTANT COMPLEXING WITH AP5A
Descriptor:Histidine triad nucleotide-binding protein 1, BIS(ADENOSINE)-5'-PENTAPHOSPHATE, ETHANESULFONIC ACID
Authors:Wang, J., Fang, P., Guo, M.
Deposit date:2019-01-11
Release date:2019-09-25
Method:X-RAY DIFFRACTION (1.02 Å)
Cite:Second Messenger Ap4A Propagates Allergic Response by Polymerizing Target Protein HINT1
To Be Published
6J5Z
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CRYSTAL STRUCTURE OF HUMAN HINT1 MUTANT COMPLEXING WITH AP3A
Descriptor:Histidine triad nucleotide-binding protein 1, ETHANESULFONIC ACID, ADENOSINE
Authors:Wang, J., Fang, P., Guo, M.
Deposit date:2019-01-12
Release date:2019-09-25
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Second Messenger Ap4A Propagates Allergic Response by Polymerizing Target Protein HINT1
To Be Published
6J64
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CRYSTAL STRUCTURE OF HUMAN HINT1 MUTANT COMPLEXING WITH AP4A
Descriptor:Histidine triad nucleotide-binding protein 1, 2-AMINOETHANESULFONIC ACID, BIS(ADENOSINE)-5'-TETRAPHOSPHATE
Authors:Wang, J., Fang, P., Guo, M.
Deposit date:2019-01-14
Release date:2019-09-25
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:Second Messenger Ap4A Propagates Allergic Response by Polymerizing Target Protein HINT1
To Be Published
6J65
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CRYSTAL STRUCTURE OF HUMAN HINT1 MUTANT COMPLEXING WITH AP4A II
Descriptor:Histidine triad nucleotide-binding protein 1, BIS(ADENOSINE)-5'-TETRAPHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Wang, J., Fang, P., Guo, M.
Deposit date:2019-01-14
Release date:2019-09-25
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Second Messenger Ap4A Propagates Allergic Response by Polymerizing Target Protein HINT1
To Be Published
6ILD
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CRYSTAL STRUCTURE OF HUMAN LYSRS: P38/AIMP2 COMPLEX II
Descriptor:Lysine--tRNA ligase, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, LYSINE, ...
Authors:Hei, Z., Liu, Z., Wang, J., Fang, P.
Deposit date:2018-10-17
Release date:2019-02-27
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (1.882 Å)
Cite:Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex.
J. Biol. Chem., 294, 2019
6ILH
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CRYSTAL STRUCTURE OF HUMAN LYSYL-TRNA SYNTHETASE L350H MUTANT
Descriptor:Lysine-tRNA ligase, 5'-O-[(L-LYSYLAMINO)SULFONYL]ADENOSINE
Authors:Hei, Z., Liu, Z., Wang, J., Fang, P.
Deposit date:2018-10-18
Release date:2019-02-27
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Retractile lysyl-tRNA synthetase-AIMP2 assembly in the human multi-aminoacyl-tRNA synthetase complex.
J. Biol. Chem., 294, 2019
5YZX
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CRYSTAL STRUCTURE OF E.COLI LYSU T146D MUTANT
Descriptor:Lysine--tRNA ligase, heat inducible, BIS(ADENOSINE)-5'-TETRAPHOSPHATE, ...
Authors:Fang, P., Guo, M.
Deposit date:2017-12-16
Release date:2018-12-19
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A proposed role for MSC to reserve the canonical function in high eukaryotes prior to stimuli
To Be Published
5ED3
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CRYSTAL STRUCTURE OF HUMAN HINT1 COMPLEXING WITH AP5A
Descriptor:Histidine triad nucleotide-binding protein 1, ADENOSINE MONOPHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Wang, J., Fang, P., Guo, M.
Deposit date:2015-10-20
Release date:2017-01-25
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.309 Å)
Cite:Convergent Regulation of Transcriptional Repression by a Second Messenger and Post-translation Modifications
To Be Published
5ED6
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CRYSTAL STRUCTURE OF HUMAN HINT1 H114A MUTANT COMPLEXING WITH ATP
Descriptor:Histidine triad nucleotide-binding protein 1, ADENOSINE MONOPHOSPHATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Wang, J., Fang, P., Guo, M.
Deposit date:2015-10-20
Release date:2017-01-25
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Convergent Regulation of Transcriptional Repression by a Second Messenger and Post-translation Modifications
To Be Published
4TTV
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CRYSTAL STRUCTURE OF HUMAN THRRS COMPLEXING WITH A BIOENGINEERED MACROLIDE BC194
Descriptor:Threonine--tRNA ligase, cytoplasmic, (1R,2R)-2-[(2S,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadec-6-en-2-yl]cyclobutanecarboxylic acid, ...
Authors:Fang, P., Guo, M.
Deposit date:2014-06-23
Release date:2015-09-30
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor.
Sci Rep, 5, 2015
5BTM
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CRYSTAL STRUCTURE OF AUUCU REPEATING RNA THAT CAUSES SPINOCEREBELLAR ATAXIA TYPE 10 (SCA10)
Descriptor:RNA (55-mer), MAGNESIUM ION, SODIUM ION
Authors:Park, H.
Deposit date:2015-06-03
Release date:2015-07-15
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.778 Å)
Cite:Crystallographic and Computational Analyses of AUUCU Repeating RNA That Causes Spinocerebellar Ataxia Type 10 (SCA10).
Biochemistry, 54, 2015
4YCV
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CRYSTAL STRUCTURE OF CLADOSPORIN IN COMPLEX WITH PLASMODIUM LYSYL-TRNA SYNTHETASE
Descriptor:Lysine--tRNA ligase, cladosporin
Authors:Fang, P., Wang, J., Guo, M.
Deposit date:2015-02-20
Release date:2015-06-24
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (3.406 Å)
Cite:Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor.
Chem.Biol., 22, 2015
4YCU
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CRYSTAL STRUCTURE OF CLADOSPORIN IN COMPLEX WITH HUMAN LYSYL-TRNA SYNTHETASE
Descriptor:Lysine--tRNA ligase, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, cladosporin, ...
Authors:Fang, P., Wang, J., Guo, M.
Deposit date:2015-02-20
Release date:2015-06-10
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for Specific Inhibition of tRNA Synthetase by an ATP Competitive Inhibitor.
Chem. Biol., 22, 2015
4YCW
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CRYSTAL STRUCTURE OF CLADOSPORIN IN COMPLEX WITH PLASMODIUM LIKE HUMAN LYSYL-TRNA SYNTHETASE MUTANT
Descriptor:Lysine--tRNA ligase, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, LYSINE, ...
Authors:Fang, P., Wang, J., Guo, M.
Deposit date:2015-02-20
Release date:2015-06-10
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Specific Inhibition of tRNA Synthetase by ATP Competitive Inhibitor
Chem.Biol., 22, 2015
4P3N
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STRUCTURAL BASIS FOR FULL-SPECTRUM INHIBITION OF THREONYL-TRNA SYNTHETASE BY BORRELIDIN 1
Descriptor:Threonine--tRNA ligase, cytoplasmic, (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid, ...
Authors:Fang, P., Yu, X., Chen, K., Chen, X., Guo, M.
Deposit date:2014-03-09
Release date:2015-03-11
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase.
Nat Commun, 6, 2015
4P3O
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STRUCTURAL BASIS FOR FULL-SPECTRUM INHIBITION OF THREONYL-TRNA SYNTHETASE BY BORRELIDIN 2
Descriptor:Threonine--tRNA ligase, ZINC ION, (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid, ...
Authors:Fang, P., Yu, X., Chen, K., Chen, X., Guo, M.
Deposit date:2014-03-09
Release date:2015-03-11
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.505 Å)
Cite:Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase.
Nat Commun, 6, 2015
4P3P
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STRUCTURAL BASIS FOR FULL-SPECTRUM INHIBITION OF THREONYL-TRNA SYNTHETASE BY BORRELIDIN 3
Descriptor:Threonine--tRNA ligase, ZINC ION, (1R,2R)-2-[(2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid, ...
Authors:Fang, P., Yu, X., Chen, K., Chen, X., Guo, M.
Deposit date:2014-03-09
Release date:2015-03-11
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for full-spectrum inhibition of translational functions on a tRNA synthetase.
Nat Commun, 6, 2015
4N20
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CRYSTAL STRUCTURE OF PROTEIN ARGININE DEIMINASE 2 (0 MM CA2+)
Descriptor:Protein-arginine deiminase type-2, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ...
Authors:Slade, D.J., Zhang, X., Fang, P., Dreyton, C.J., Zhang, Y., Gross, M.L., Guo, M., Coonrod, S.A., Thompson, P.R.
Deposit date:2013-10-04
Release date:2015-02-04
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.657 Å)
Cite:Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.
Acs Chem.Biol., 10, 2015
4N22
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CRYSTAL STRUCTURE OF PROTEIN ARGININE DEIMINASE 2 (50 UM CA2+)
Descriptor:Protein-arginine deiminase type-2, ACETATE ION, GLYCEROL, ...
Authors:Slade, D.J., Zhang, X., Fang, P., Dreyton, C.J., Zhang, Y., Gross, M.L., Guo, M., Coonrod, S.A., Thompson, P.R.
Deposit date:2013-10-04
Release date:2015-02-04
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.889 Å)
Cite:Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.
Acs Chem.Biol., 10, 2015
4N24
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CRYSTAL STRUCTURE OF PROTEIN ARGININE DEIMINASE 2 (100 UM CA2+)
Descriptor:Protein-arginine deiminase type-2, (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:Slade, D.J., Zhang, X., Fang, P., Dreyton, C.J., Zhang, Y., Gross, M.L., Guo, M., Coonrod, S.A., Thompson, P.R.
Deposit date:2013-10-04
Release date:2015-02-04
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (1.968 Å)
Cite:Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.
Acs Chem.Biol., 10, 2015
4N25
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CRYSTAL STRUCTURE OF PROTEIN ARGININE DEIMINASE 2 (250 UM CA2+)
Descriptor:Protein-arginine deiminase type-2, (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:Slade, D.J., Zhang, X., Fang, P., Dreyton, C.J., Zhang, Y., Gross, M.L., Guo, M., Coonrod, S.A., Thompson, P.R.
Deposit date:2013-10-04
Release date:2015-02-04
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (1.931 Å)
Cite:Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.
Acs Chem.Biol., 10, 2015
4N26
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CRYSTAL STRUCTURE OF PROTEIN ARGININE DEIMINASE 2 (500 UM CA2+)
Descriptor:Protein-arginine deiminase type-2, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ...
Authors:Slade, D.J., Zhang, X., Fang, P., Dreyton, C.J., Zhang, Y., Gross, M.L., Guo, M., Coonrod, S.A., Thompson, P.R.
Deposit date:2013-10-04
Release date:2015-02-04
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (1.943 Å)
Cite:Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.
Acs Chem.Biol., 10, 2015
4N28
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CRYSTAL STRUCTURE OF PROTEIN ARGININE DEIMINASE 2 (1 MM CA2+)
Descriptor:Protein-arginine deiminase type-2, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ...
Authors:Slade, D.J., Zhang, X., Fang, P., Dreyton, C.J., Zhang, Y., Gross, M.L., Guo, M., Coonrod, S.A., Thompson, P.R.
Deposit date:2013-10-04
Release date:2015-02-04
Last modified:2015-05-06
Method:X-RAY DIFFRACTION (1.879 Å)
Cite:Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.
Acs Chem.Biol., 10, 2015
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