4TTV
Crystal structure of human ThrRS complexing with a bioengineered macrolide BC194
Summary for 4TTV
Entry DOI | 10.2210/pdb4ttv/pdb |
Descriptor | Threonine--tRNA ligase, cytoplasmic, (1R,2R)-2-[(2S,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadec-6-en-2-yl]cyclobutanecarboxylic acid, ZINC ION, ... (4 entities in total) |
Functional Keywords | trna, synthetase, inhibitor, macrolide, ligase-antibiotic complex, ligase/antibiotic |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 195815.89 |
Authors | |
Primary citation | Mirando, A.C.,Fang, P.,Williams, T.F.,Baldor, L.C.,Howe, A.K.,Ebert, A.M.,Wilkinson, B.,Lounsbury, K.M.,Guo, M.,Francklyn, C.S. Aminoacyl-tRNA synthetase dependent angiogenesis revealed by a bioengineered macrolide inhibitor. Sci Rep, 5:13160-13160, 2015 Cited by PubMed: 26271225DOI: 10.1038/srep13160 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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